Trinity Health System Executive and Leadership Team

September, 2026

Leadership Overview

Trinity Health System has 5 executives leading key functions including operations, marketing, medical administration, and enterprise strategy.

Dedicated to compassionate care, Trinity Health System advances a faith-based mission by integrating comprehensive medical services across the United States to improve community health outcomes and support vulnerable populations.

Leadership Roles at Trinity Health System

  • Vice President, Operations & Chief Operating Officer - Paul Wheeler
  • Vice President, Operations & Chief Operating Officer - Paul Ache
  • Group President, Medical Enterprise - James Mirasola
  • Chief Marketing Officer, Vpma - Nicholas Economides
  • Chief Medical Officer - Matthew Colflesh
  • Paul Wheeler - Vice President, Operations & Chief Operating Officer

    Paul Wheeler, the Vice President, Operations & Chief Operating Officer at Trinity Health System, directs the internal infrastructure of the hospital network. Wheeler manages the daily clinical workflows and resource allocation across the organization to ensure high-quality patient outcomes. By optimizing hospital efficiency, the Chief Operating Officer maintains the operational integrity of the entire system. This leadership role involves coordinating with regional directors to standardize care delivery protocols across diverse medical facilities. Paul Wheeler also oversees the integration of new outpatient centers into the existing network, ensuring seamless service expansion. Through rigorous performance monitoring, the Chief Operating Officer drives cost-effective management practices that support the long-term sustainability of the healthcare ministry. By focusing on operational excellence, Wheeler strengthens the ability of the organization to provide accessible medical services to communities throughout the United States.

    Paul Ache - Vice President, Operations & Chief Operating Officer

    Paul Ache, the Vice President, Operations & Chief Operating Officer at Trinity Health System, manages the supply chain logistics and facility maintenance for the expansive hospital network. Ache oversees the procurement of medical equipment and essential supplies required for daily clinical operations. By streamlining the distribution of resources, the Chief Operating Officer ensures that every facility maintains the capacity to deliver high-quality care. This leadership role involves implementing advanced inventory management systems to reduce waste and improve operational speed. Paul Ache also coordinates with external vendors to secure reliable partnerships that support the mission of the organization. Through the oversight of physical infrastructure, the Chief Operating Officer drives improvements in facility safety and patient comfort. By focusing on the logistical backbone of the healthcare system, Ache enables clinical staff to prioritize patient needs while maintaining the highest standards of service across the United States.

    James Mirasola - Group President, Medical Enterprise

    James Mirasola, the Group President, Medical Enterprise at Trinity Health System, architects the strategic growth and long-term development of the medical service portfolio. Mirasola oversees the expansion of the integrated system, including the acquisition and integration of new clinics and specialized health services. By analyzing market trends and community health needs, the Group President, Medical Enterprise identifies opportunities to broaden the reach of the organization. This leadership role involves working closely with the Board to align enterprise-wide goals with the mission of providing charitable care and community support. James Mirasola also manages the financial performance of the medical enterprise, ensuring that resources are allocated to maximize impact on public health. Through the development of innovative care models, the Group President, Medical Enterprise drives the evolution of the healthcare delivery system. By focusing on strategic scalability, Mirasola secures the future of the organization as a premier provider of compassionate medical services.

    Nicholas Economides - Chief Marketing Officer, Vpma

    Nicholas Economides, the Chief Marketing Officer, Vpma at Trinity Health System, architects the brand strategy and public outreach initiatives for the entire organization. Economides manages the communication channels that connect the healthcare ministry with diverse patient populations. By aligning marketing efforts with the core mission of compassion and service, the Chief Marketing Officer, Vpma ensures that community health programs receive necessary visibility. This leadership role involves collaborating with clinical teams to promote specialized medical services and wellness initiatives. Nicholas Economides also oversees the digital engagement strategy, enhancing accessibility for patients seeking information about long-term care and outpatient services. Through data-driven campaigns, the Chief Marketing Officer, Vpma expands the reach of the organization into underserved regions. By maintaining a strong public presence, Economides supports the overarching goal of improving community well-being through transparent and empathetic communication.

    Matthew Colflesh - Chief Medical Officer

    Matthew Colflesh, the Chief Medical Officer at Trinity Health System, directs the clinical standards and medical quality protocols across the entire organization. Colflesh oversees the physician workforce and ensures that all medical practices align with the faith-based mission of the healthcare ministry. By implementing evidence-based care guidelines, the Chief Medical Officer maintains high standards of patient safety and clinical excellence. This leadership role involves collaborating with hospital administrators to address complex medical challenges and improve health outcomes for diverse patient populations. Matthew Colflesh also leads initiatives focused on chronic disease management and preventative care within the community. Through the continuous evaluation of clinical performance, the Chief Medical Officer drives improvements in medical service delivery. By fostering a culture of compassion and professional development, Colflesh ensures that the organization remains a leader in providing high-quality, accessible healthcare services throughout the country.

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    Frequently Asked Questions Regarding Trinity Health System Top Executives and Leadership Team

    Who leads Trinity Health System?
    Trinity Health System is led by Paul Wheeler (Vice President, Operations & Chief Operating Officer), along with executives such as Paul Ache (Vice President, Operations & Chief Operating Officer) and James Mirasola (Group President, Medical Enterprise).
    Who is part of Trinity Health System’s executive team?
    The executive team of Trinity Health System includes leaders such as Paul Wheeler (Vice President, Operations & Chief Operating Officer), Paul Ache (Vice President, Operations & Chief Operating Officer), James Mirasola (Group President, Medical Enterprise) and other senior executives.
    How many executives does Trinity Health System have?
    Trinity Health System has 5 executives leading key business areas.
    What roles are included in Trinity Health System’s leadership team?
    The leadership team of Trinity Health System includes roles such as Vice President, Operations & Chief Operating Officer, Vice President, Operations & Chief Operating Officer, Group President, Medical Enterprise, Chief Marketing Officer, Vpma, Chief Medical Officer.