Tvardi Therapeutics
Business Services · Texas, United States · 11-50 Employees
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Overview
Headquarters
3 Sugar Creek Center Blvd Ste 525, Sugar...Phone Number
(713) 489-8654Website
www.tvarditherapeutics.comRevenue
-Stock Symbol
TVRDIndustry
ZI Rank: 1
Signal Type
Mar
Apr
May
Jun
Jul
Aug
ZI Rank
2
1
1
1
1
1
About Tvardi Therapeutics
Tvardi Therapeutics, Inc. is a clinical-stage biopharmaceutical company operating in the biotechnology and drug development industry, headquartered in Houston, Texas. The company focuses on developing novel, oral small molecule therapies targeting STAT3, a transcription factor central to fibrotic and cancer-related signaling pathways, to treat inflammatory and fibrosis-driven diseases with significant unmet medical need. Its pipeline includes STAT3 inhibitors TTI-101 and TTI-109, currently in clinical development for conditions such as hepatocellular carcinoma.Explore more
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Company Profile Activity
Activity Insights
Tvardi Therapeutics is experiencing very low activity levels compared to other companies in the Business Services sector.
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Tvardi Therapeutics is drawing exceptional interest within the Business Services industry, suggesting notable developments or strong market momentum, learn more about Tvardi Therapeutics.
Tvardi Therapeutics financials insights
Gather financial insights about Tvardi Therapeutics, including details on funding rounds, investors, total funding, and acquisitions, to gain a comprehensive understanding of their financial strategy.
2018
Series A
$9M
2020
Grant
$5M
2021
Series B
$74M
Tvardi Therapeutics Tech Stack
A closer look at the technologies used by Tvardi Therapeutics
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Most Recent Scoops
Project
Tvardi Therapeutics has reported Phase I oncology clinical data for TTI-101 demonstrating target engagement, including a median 55% reduction in activated STAT3 via paired biopsies, a 79% reduction among patients achieving stable disease, and a 100% response rate in patients with elevated baseline activated STAT3 within approximately six weeks.
Medical Research, Clinical Operations
Project
Tvardi Therapeutics has reported preclinical data from a DSS colitis model showing that STAT3 inhibitor-treated murine colons were essentially indistinguishable from healthy controls in colon length and architecture, with a third-party literature comparison indicating 90% recovery on colon length and colonic inflammation score, outperforming approved tofacitinib and other direct STAT3 candidates tested in the same model.
Medical Research, Pharmaceuticals
Project
Tvardi Therapeutics has reported data from the REVERT Phase II study of TTI-101 in idiopathic pulmonary fibrosis, showing a greater than fourfold difference versus placebo in the slope of IL-6 and a seven percentage point improvement versus placebo in fibrosis score at 12 weeks, representing a decrease from baseline not previously reported in any other IPF trial within that timeframe.
Medical Research, Pharmaceuticals
Project
Tvardi Therapeutics has reported new immune modulation data from the TTI-109 Phase I healthy volunteer study, showing downregulation across 16 cellular and humoral immune subsets recognized as pathologic markers of inflammatory and proliferative disease, with key markers reduced by up to 60% and a consistent directional pattern observed across all three active dose levels, yielding a probability of less than 1 in 65,000 that the results occurred by random fluctuation.
Medical Research, Pharmaceuticals
Project
Medical Research, Pharmaceuticals
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Frequently Asked Questions Regarding Tvardi Therapeutics
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Tvardi Therapeutics, Inc. is a clinical-stage biopharmaceutical company operating in the biotechnology and drug development industry, headquartered in Houston, Texas. The company focuses on developing novel, oral small molecule therapies targeting STAT3, a transcription factor central to fibrotic and cancer-related signaling pathways, to treat infl... Read More
