Where is Express Scripts Headquarters?
Main Office Address and Global Locations

The official headquarters of Express Scripts Holding Co is located at 1 Express Way, Saint Louis, Missouri, United States. This facility serves as the primary base for the organization, situated within a region that supports its extensive logistics and administrative requirements. The site encompasses significant office space designed to accommodate the various departments necessary for managing pharmacy benefits and specialty care programs. As a large-scale corporate campus, the location is structured to facilitate the daily operations of a company that serves millions of members across the country. The physical layout reflects the functional needs of a major managed care entity, providing the infrastructure required for its ongoing business activities. This location functions as the operational heart of the company, housing key executive leadership and core administrative teams that oversee national operations. By centralizing these critical functions in Saint Louis, the company maintains oversight of its pharmacy benefit management services and client relations. The facility acts as the strategic core for coordinating with managed care organizations, third-party administrators, and various employer groups. It supports the broader network of regional offices by providing centralized policy guidance and technical support for its specialty managed care initiatives. This command center remains essential to the company's ability to deliver consistent service standards to its diverse client base throughout North America.