What is System?
System operates as a Public Benefit Corporation dedicated to transforming fragmented data silos into cohesive, actionable knowledge systems. At the heart of its value proposition is the System Graph, a patented, large-scale statistical model that synthesizes trusted evidence into an interconnected framework. By providing APIs that power clinical decision support systems (CDSS), System enables healthcare providers in the United States and Europe to navigate complex medical data with unprecedented precision. The company's focus on systems thinking positions it as a foundational layer in the digital health ecosystem, bridging the gap between raw research and clinical application.
How much funding has System raised?
System has raised a total of $16.5M across 2 funding rounds:
Series A
$10M
Unspecified
$6.5M
Series A (2021): $10M with participation from Acrew Capital Management
Unspecified (2025): $6.5M led by The Wellcome Trust
Key Investors in System
Acrew Capital Management
Acrew Capital is a venture capital firm focused on redefining the future of venture through long-term partnerships and deep conviction in investment decisions, supporting companies from Seed to growth stages.
The Wellcome Trust
Wellcome is an independent global charitable foundation based in London that supports discovery research and tackles urgent health challenges through grants, partnerships, and advocacy.
What's next for System?
With this recent financing, System is well-positioned to accelerate the deployment of its knowledge infrastructure. The strategic roadmap likely involves deepening the integration of the System Graph within existing hospital workflows and expanding the breadth of its evidence-based datasets. As the company scales, it will focus on enhancing the interoperability of its APIs, thereby solidifying its market position as a critical utility for healthcare providers. The focus remains on scaling the impact of its technology, ensuring that the transition from siloed information to systemic intelligence continues to drive better patient outcomes and operational efficiency on a global scale.
See full System company page
