Vertex Executive and Leadership Team

September, 2026

Leadership Overview

Vertex has 10 executives leading key functions including strategy, revenue generation, human capital, patient advocacy, and quality assurance.

Driven by a commitment to scientific innovation, Vertex develops transformative medicines for serious diseases while advancing research programs in genetic disorders to improve patient outcomes globally.

Leadership Roles at Vertex

  • President & Chief Executive Officer - Reshma Kewalramani
  • Toxicology Research Senior Scientist & Chief Revenue Officer, Study Monitor - Colleen O'Brien
  • Senior Vice President and Chief Human Resources Officer, Vertex Pharmaceuticals - Stephanie Franklin
  • Senior Director, Chief of Staff To the Chief Patient and External Affairs Officer - Tatum Murray
  • Senior Director, Chief of Staff To the Senior Vice President of Quality - Dionna Di Pierro
  • Senior VP & Chief Human Resources Officer - Stephanie Franklin
  • Executive Assistant To Chief Human Resources Officer - Amy Longwell
  • Head To of Cell & Gene Therapy Research Chief of Staff - Adila Crimi
  • Senior Principal Scientist and Chief Revenue Officer Monitor and Associate Director - Sazzad Hussain
  • Director, Chief of Staff - Global Commercial Strategy - Moira Scanlon
  • Reshma Kewalramani - President & Chief Executive Officer

    Reshma Kewalramani, the President & Chief Executive Officer at Vertex, directs the overarching corporate strategy and research initiatives for the biotechnology firm. Overseeing the development of therapies for cystic fibrosis and sickle cell disease, the President & Chief Executive Officer ensures alignment between scientific discovery and commercial viability. This leadership role involves managing complex global operations to address significant unmet medical needs across diverse patient populations. By fostering a culture of innovation, Reshma Kewalramani drives the organization toward breakthroughs in type 1 diabetes and kidney disease research. The President & Chief Executive Officer maintains rigorous standards for clinical excellence while expanding the company footprint in international markets. Through strategic resource allocation, the executive secures the long-term growth trajectory of the enterprise, ensuring that every therapeutic program delivers tangible value to healthcare providers and patients worldwide.
    Reshma Kewalramani

    Colleen O'Brien - Toxicology Research Senior Scientist & Chief Revenue Officer, Study Monitor

    Colleen O'Brien, the Toxicology Research Senior Scientist & Chief Revenue Officer, Study Monitor at Vertex, manages the intersection of preclinical safety data and commercial revenue streams. Focusing on the rigorous evaluation of drug toxicity, the Toxicology Research Senior Scientist & Chief Revenue Officer, Study Monitor ensures that all research programs meet stringent regulatory requirements before market entry. This role involves analyzing complex biological data to support the development of therapies for genetic disorders and acute pain. By optimizing the revenue cycle through precise study monitoring, Colleen O'Brien directly impacts the financial stability of the organization. The Toxicology Research Senior Scientist & Chief Revenue Officer, Study Monitor coordinates with clinical teams to validate the safety profiles of new medicines, thereby facilitating smoother transitions from laboratory research to patient-facing applications. This strategic oversight ensures that the company maintains a competitive edge in the global biotechnology landscape.

    Stephanie Franklin - Senior Vice President and Chief Human Resources Officer, Vertex Pharmaceuticals

    Stephanie Franklin, the Senior Vice President and Chief Human Resources Officer, Vertex Pharmaceuticals at Vertex, architects the talent acquisition and organizational development strategies necessary to support a high-growth biotechnology environment. Overseeing the recruitment of top-tier scientific and operational talent, the Senior Vice President and Chief Human Resources Officer, Vertex Pharmaceuticals ensures that the workforce remains aligned with the mission of delivering medicines for serious diseases. This leadership role involves designing comprehensive performance management systems and fostering an inclusive culture that drives innovation across all departments. By implementing strategic human capital initiatives, Stephanie Franklin enhances employee engagement and retention, which directly supports the company ability to scale research programs in type 1 diabetes and myotonic dystrophy. The Senior Vice President and Chief Human Resources Officer, Vertex Pharmaceuticals collaborates with the executive team to build a resilient organizational structure capable of navigating the complexities of the global pharmaceutical industry.

    Tatum Murray - Senior Director, Chief of Staff To the Chief Patient and External Affairs Officer

    Tatum Murray, the Senior Director, Chief of Staff To the Chief Patient and External Affairs Officer at Vertex, coordinates the strategic priorities and external communications for the patient advocacy division. Overseeing the integration of patient perspectives into the drug development lifecycle, the Senior Director, Chief of Staff To the Chief Patient and External Affairs Officer ensures that the company remains responsive to the needs of those suffering from sickle cell disease and transfusion-dependent beta thalassemia. This role involves managing high-level relationships with specialty pharmacies, hospitals, and patient organizations to facilitate broader access to life-saving therapies. By streamlining internal operations, Tatum Murray enables the Chief Patient and External Affairs Officer to focus on long-term advocacy goals and market impact. The Senior Director, Chief of Staff To the Chief Patient and External Affairs Officer drives the execution of external affairs strategies that solidify the reputation of the firm as a leader in patient-centric biotechnology.

    Dionna Di Pierro - Senior Director, Chief of Staff To the Senior Vice President of Quality

    Dionna Di Pierro, the Senior Director, Chief of Staff To the Senior Vice President of Quality at Vertex, manages the operational workflows and quality assurance protocols that govern the manufacturing of biotechnology products. Overseeing the alignment of quality standards with global regulatory expectations, the Senior Director, Chief of Staff To the Senior Vice President of Quality ensures that every medicine produced meets the highest safety and efficacy benchmarks. This role involves coordinating cross-functional teams to address quality challenges in the development of therapies for genetic disorders. By optimizing internal processes, Dionna Di Pierro supports the Senior Vice President of Quality in maintaining a robust supply chain that serves hospitals and distributors worldwide. The Senior Director, Chief of Staff To the Senior Vice President of Quality drives the implementation of continuous improvement initiatives, ensuring that the company maintains its commitment to excellence in every stage of the pharmaceutical production cycle.

    Stephanie Franklin - Senior VP & Chief Human Resources Officer

    Stephanie Franklin, the Senior VP & Chief Human Resources Officer at Vertex, directs the strategic planning of organizational culture and leadership development programs. Focusing on the internal infrastructure required to support research in kidney disease and myotonic dystrophy, the Senior VP & Chief Human Resources Officer ensures that the company attracts and retains the specialized expertise needed for complex biotechnology innovation. This role involves managing compensation structures and performance metrics that incentivize high-impact scientific contributions. By aligning human resources strategies with the broader corporate mission, Stephanie Franklin fosters an environment where cross-functional collaboration thrives. The Senior VP & Chief Human Resources Officer works closely with the Board to ensure that the leadership pipeline remains strong and capable of navigating the evolving demands of the global pharmaceutical market. Through these efforts, the executive secures the operational foundation necessary for the company to continue delivering transformative medicines to patients.
    Stephanie Franklin

    Amy Longwell - Executive Assistant To Chief Human Resources Officer

    Amy Longwell, the Executive Assistant To Chief Human Resources Officer at Vertex, manages the administrative operations and scheduling priorities for the human resources leadership team. Overseeing the coordination of executive meetings and internal communications, the Executive Assistant To Chief Human Resources Officer ensures that the department functions with maximum efficiency. This role involves tracking key human capital projects and facilitating the flow of information between the Chief Human Resources Officer and other senior leaders. By maintaining organized systems for talent management and organizational planning, Amy Longwell supports the broader mission of the company to attract and retain top-tier talent for the development of medicines for serious diseases. The Executive Assistant To Chief Human Resources Officer plays a vital role in ensuring that the leadership team remains focused on strategic initiatives, thereby contributing to the overall success of the biotechnology firm in its mission to serve patients worldwide.

    Adila Crimi - Head To of Cell & Gene Therapy Research Chief of Staff

    Adila Crimi, the Head To of Cell & Gene Therapy Research Chief of Staff at Vertex, directs the operational activities and research priorities within the cell and gene therapy division. Overseeing the development of innovative treatments for genetic disorders, the Head To of Cell & Gene Therapy Research Chief of Staff ensures that scientific teams have the resources and strategic guidance necessary to advance clinical programs. This role involves managing the interface between laboratory research and the broader corporate strategy for addressing unmet medical needs. By coordinating complex research projects, Adila Crimi facilitates the rapid progression of therapies from the bench to the clinic. The Head To of Cell & Gene Therapy Research Chief of Staff works to ensure that the research pipeline remains robust and aligned with the long-term goals of the company, ultimately driving the development of next-generation medicines for patients suffering from serious, life-altering conditions.

    Sazzad Hussain - Senior Principal Scientist and Chief Revenue Officer Monitor and Associate Director

    Sazzad Hussain, the Senior Principal Scientist and Chief Revenue Officer Monitor and Associate Director at Vertex, manages the technical validation of research data while monitoring revenue-generating clinical trials. Focusing on the scientific integrity of programs targeting acute pain and genetic disorders, the Senior Principal Scientist and Chief Revenue Officer Monitor and Associate Director ensures that all data collection meets the rigorous standards required for commercial success. This role involves overseeing the associate director functions to maintain project timelines and budget adherence. By bridging the gap between scientific research and financial performance, Sazzad Hussain supports the company ability to bring new therapies to market efficiently. The Senior Principal Scientist and Chief Revenue Officer Monitor and Associate Director coordinates with cross-functional teams to ensure that clinical outcomes are accurately captured and reported, thereby maximizing the impact of the company portfolio on global healthcare markets and patient outcomes.
    Sazzad Hussain

    Moira Scanlon - Director, Chief of Staff - Global Commercial Strategy

    Moira Scanlon, the Director, Chief of Staff - Global Commercial Strategy at Vertex, coordinates the execution of commercial initiatives across international markets. Overseeing the alignment of global sales strategies with the company mission to provide medicines for serious diseases, the Director, Chief of Staff - Global Commercial Strategy ensures that regional operations remain consistent with corporate objectives. This role involves managing the strategic planning process for the commercial division and facilitating communication between leadership and global distributors. By optimizing the commercial roadmap, Moira Scanlon supports the expansion of access to therapies for cystic fibrosis and other genetic conditions. The Director, Chief of Staff - Global Commercial Strategy drives the implementation of market-entry strategies that allow the company to reach patients through hospitals and specialty pharmacies worldwide. Through these efforts, the executive ensures that the commercial organization remains agile and responsive to the evolving needs of the global healthcare landscape.

    Explore Leadership Teams in Manufacturing

    Frequently Asked Questions Regarding Vertex Top Executives and Leadership Team

    Who leads Vertex?
    Vertex is led by Reshma Kewalramani (President & Chief Executive Officer), along with executives such as Colleen O'Brien (Toxicology Research Senior Scientist & Chief Revenue Officer, Study Monitor) and Stephanie Franklin (Senior Vice President and Chief Human Resources Officer, Vertex Pharmaceuticals).
    Who is part of Vertex’s executive team?
    The executive team of Vertex includes leaders such as Reshma Kewalramani (President & Chief Executive Officer), Colleen O'Brien (Toxicology Research Senior Scientist & Chief Revenue Officer, Study Monitor), Stephanie Franklin (Senior Vice President and Chief Human Resources Officer, Vertex Pharmaceuticals) and other senior executives.
    How many executives does Vertex have?
    Vertex has 10 executives leading key business areas.
    What roles are included in Vertex’s leadership team?
    The leadership team of Vertex includes roles such as President & Chief Executive Officer, Toxicology Research Senior Scientist & Chief Revenue Officer, Study Monitor, Senior Vice President and Chief Human Resources Officer, Vertex Pharmaceuticals, Senior Director, Chief of Staff To the Chief Patient and External Affairs Officer, Senior Director, Chief of Staff To the Senior Vice President of Quality.