The ALS CURE Project

ALS CURE Project president, Mike Piscotty (cALS) is leading an international project team consisting of international ALS researchers and machine learning computer scientists from Canada and the US. ALS is a fatal progressive neurological disease. The 3ML team is developing a multi-modal machine learning model to analyze ALS disease progression usi... ng MRI's (T1, Flair and DTI sequences), proteomics and neurofilaments derived from blood plasma obtained from patients from 3 consecutive clinic visits (every 3 months).along with weekly speech measures (digital biomarker). The 3ML project is currently enrolling patients in Canada and the US. The 3ML model will run in each country and will send anonymized summary results to an international datahub where the results will be made available to the international ALS research community. Funds raised by Donna's coast to coast bicycle trek campaign will be used to pay for the mass spectrometer analyses of the blood plasma to feed proteomics to the 3ML model. Physics-based Modeling of TDP-43 AggregationRead More