Sapient

Sapient is focused on the discovery of dynamic biomarkers beyond the genome, providing bespoke services for discovery metabolomics and lipidomics using state-of-the-art, high-throughput mass spectrometry technologies for rapid, nontargeted measure of 15K small molecule biomarkers per sample. Our approach to small molecule biomarker profiling provid... es an unprecedented view into the exposures and factors that modulate health, disease, and drug response across individuals over time, which is needed to more effectively align biological targets, patients, and therapies. These technologies are leveraged within a larger discovery infrastructure that includes a comprehensive biocomputational framework for analysis of large-scale spectral data, robust quality control analysis, and mapping of key biomarker-phenotype associations. Sapient can cross-validate discoveries using our proprietary longitudinal Human Biology Database that includes mass spectrometry measures from over 100,000 human biosamples linked with corresponding clinical and multi-dimensional -omics data. Together our methods enable rapid identification, validation, and translation of small molecule biomarkers of biological processes, disease mechanisms, and drug response across all drug development phases.Read More