FUJIFILM

Fujifilm has actively promoted the research and development of liposome formulations by harnessing its advanced nano-dispersion technology, analysis technology, and process technology cultivated and evolved through its wide range of product development. In 2017, the company began a U.S. Phase I clinical trial of FF-10832, a liposome-based agent tha... t encapsulates the approved anti-cancer agent gemcitabine *** . In the preclinical mice studies on FF-10850 and FF-10832 *4 Fujifilm has observed the extension of the survival period as a result of immune checkpoint inhibitor *5 combination therapy. In addition, Fujifilm has been promoting the application of liposome for use with next-generation drugs such as nucleic acid drugs and gene therapy drugs. Looking towards future growth, in order to ensure a stable supply of high-quality liposome formulations, Fujifilm is developing a manufacturing facility for producing investigational and commercial drugs through its subsidiary, FUJIFILM Toyama Chemical Co., Ltd. The facility is planned to begin operations in February 2020. Fujifilm is harnessing its unique technologies to undertake the development of new drugs in the priority areas including oncology. The company is also focusing on developing DDS technologies to create new value and contributing to the resolution of social issues. * An anti-cancer agent (generic name: topotecan, product name: Hycamtin) developed by GlaxoSmithKline plc. Currently, the drug is being sold by Novartis. It is used as a treatment for ovarian cancer, small-cell lung cancer, cervical cancer, etc. ** Because of the adverse reaction of anti-cancer agents, the functions of bone marrow are suppressed, and the production of white blood cells, platelets, and red blood cells is reduced, leading to increased risk of infection, bleeding and anemia. With topotecan, severe bone marrow suppression is seen in over 80% of the patients. *** An anti-cancer drug (generic name: gemcitabine, product name: Gemzar) developed by Eli Lilly and Company. It is used ...Read More