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Samuel Strober

Professor

Stanford University

HQ Phone:  (650) 723-2300

Direct Phone: (650) ***-****direct phone

Email: s***@***.edu

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Stanford University

341 Galvez St

Stanford, California, 94305

United States

Company Description

Stanford University, located between San Francisco and San Jose in the heart of California's Silicon Valley, is one of the world's leading teaching and research universities. Since its opening in 1891, Stanford has been dedicated to finding solutions to big ch...more

Find other employees at this company (47,585)

Background Information

Employment History

Scientific Founder

Dendreon Corporation


Affiliations

La Jolla Institute for Allergy and Immunology

Scientific Advisory Board Member


Medeor Therapeutics Inc

Board Member


Innate Immune

Founder


Education

B.A.

Columbia University


M.D.

Harvard University


Web References(55 Total References)


Affinity Billing - Renal Billing Service with Comprehensive Nephrology Practice Management Software.

In a letter in the Oct. 6 New England Journal of Medicine, Dr. Samuel Strober describes the protocol he invented and reports on data from 12 kidney transplant patients who received a new kidney from a "perfect match," typically a sibling.
Eight of the patients, who ranged in age from 22 to 68 and underwent the stem cell therapy, have now been off immune-suppressing drugs for at least a year. For some, the drug-free stretch has lasted as long as three years, Strober said. "Organ transplantation has been a very successful enterprise in treating people with organ failure kidneys, hearts, the lungs. These have been life-saving procedures. But the price people still have to pay is lifelong use of medications that prevent rejection," said Strober, an immunologist and professor of medicine at Stanford. Strober said his new method, honed over 30 years of research in mice, involves a combination of radiation, donor stem cells, and antibodies (proteins that help deplete some of the patient's own immune cells). Following transplant surgery in the hospital, the kidney recipient receives radiation targeted at the lymph nodes, spleen and thymus gland to temporarily weaken the immune system. The antibodies are given then, too. Ten days later, the organ donor's stem cells, called hematopoietic progenitor cells -- which form blood and immune-system cells -- are infused into the new kidney patient on an outpatient basis. The donors stem cells, over time, differentiate and join with the transplant patients own immune system, making it more receptive to the donor kidney, Strober said. A couple of immunosuppressant drugs are given early on, too, he said, but the patient is weaned off of them if no signs of rejection appear within the early months. "The goal of the study was to try and eliminate the use of lifelong drugs and keep the transplant. So far, so good," Strober said, referring to the eight study patients who no longer take anti-rejection medication and whose kidneys were functioning well.


Leadership | La Jolla Institute For Allergy and Immunology

Samuel Strober, M.D.
Professor of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine Explore :Research Areas


MEDEOR THERAPEUTICS

Samuel Strober, M.D.
Scientific Founder and Board Member Dr. Strober is Professor of Medicine at Stanford University School of Medicine and former Chief of the Division of Immunology and Rheumatology. He has been President of the Clinical Immunology Society, Chairman of the Board of the La Jolla Institute for Allergy and Immunology and was a scientific founder of Dendreon Corporation. Dr. Strober's research has focused on the immune cell interactions that prevent rejection of organ transplants in the absence of immunosuppressive drugs as well as cell interactions that prevent graft versus host disease and retain graft anti-tumor activity after hematopoietic cell transplantation. Dr. Strober has published over 300 peer-reviewed articles in scientific journals, is the inventor of multiple patented technologies, and has served on editorial boards of immunology journals He received his B.A. from Columbia University and his M.D. from Harvard University.


Millions of Jobs Stuck in Patent Office Backlog | American Jobs Alliance

Consider the case of Silicon Valley startup Innate Immune, founded by world-renowned Stanford immunologist Sam Strober.


Sheffield Kidney Institute - Induced Immune Tolerance for Kidney Transplantation

Samuel Strober, M.D.
Stanford University School of Medicine, Stanford, CA This e-mail address is being protected from spambots.


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