Ke Dong

last updated 6/19/2017

Ke Dong

Professor at Michigan State University

Location:
2857 West Jolly Road, Okemos, Michigan, United States
HQ Phone:
(517) 349-6200

Recent News  

Michigan State University - University Research Corridor

Ke Dong, MSU insect toxicologist and neurobiologist, has found a way to maintain a popular insecticide's effectiveness against pests without killing beneficial bugs, such as bees.
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Executive Committee - AGRO DivisionAGRO Division

Ke Dong
Ke Dong Michigan State University

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Items of interest to beekeepers 9 December 2017 - Canadian Honey Council

Ke Dong, MSU insect toxicologist and neurobiologist and co-author of the paper, honed in on a single protein that could afford bumble bees the same resistance as humans - tau-fluvalinate, a pyrethroid insecticide.
Dong worked with Shaoying Wu, lead author from Henan Agricultural University (China), who conducted the research in Dong's lab as a visiting scholar. "For the first time we are showing that unique structural features in bee sodium channels interfere with the binding of tau-fluvalinate to bumble bee sodium channels," said Dong. "This opens the possibility of designing new chemicals that target sodium channels of pests but spare bees. Sodium channels are large transmembrane proteins of more than 2,000 amino acid residues. Dong's lab spent many years unraveling this groundbreaking advance. The scientists initially started with sodium channels from other bugs, such as mosquitoes, fruit flies, cockroaches, mites and ticks, to find where pyrethroids bind on insect sodium channels to effectively kill them. They got some help from nature. "By examining wild mosquitoes that have become resistant to pyrethroids, we were able to help narrow down the potential sites on which to focus," Dong said. Specifically, in a previous study, Dong and the team identified mutations that made the channels more resistant to pyrethroids. Journal Reference: Shaoying Wu, Yoshiko Nomura, Yuzhe Du, Boris S. Zhorov, Ke Dong.

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