George Perkins

George H. Perkins

Professor, Medical Director, and Chief Medical Officer at The University of Texas MD Anderson Cancer Center

1515 Holcombe Blvd., Houston, Texas, United States
HQ Phone:
(713) 792-2121

General Information


Associate Professor  - M. D. Anderson Department of Radiation Oncology


M.D.  - 

Recent News  

"Our findings indicate another potentially unfavorable aspect associated with a widely accepted as favorable breast cancer subtype," said George H. Perkins, M.D., associate professor in the Division of Radiation Oncology at The University of Texas M. D. Anderson Cancer Center.
"In an era of concern regarding overtreatment, we caution in our findings that undertreatment could also become a significant hazard for patients and thus should be a significant area of concern," he said. Perkins presented results of this study at the CTRC-AACR Annual San Antonio Breast Cancer Symposium, held Dec. 9-13, 2009. Mucinous carcinoma is a rare form of cancer, diagnosed in about 2 percent of patients with breast cancer. Cancer cells within the breast produce mucous, forming a jelly-like tumor. Previous research has shown that the disease has a favorable prognosis; therefore, investigators have recommended treating patients with the minimal effective therapy vs. the maximum tolerated treatment. "Our results are from one of the largest single institution experiences with a relatively uncommon subtype and has significant, long-term follow-up of patients," Perkins said. "We emphasize multidisciplinary, comprehensive care to avoid the non-recognition of additional occult disease, which could affect patient outcomes." Perkins and colleagues reviewed charts for 264 patients diagnosed with a pure mucinous carcinoma from 1965 to 2005. "We have been previously surprised by the decreasing age at presentation in this population, and by the regression of favorable outcomes towards the lower outcomes of other common breast cancer subtypes over time," Perkins said. "This reinforces our commitment to interdisciplinary care and true personalized patient treatment in this variant. Patients should receive the care indicated, rather than receive the assumption that it may not matter which treatment approach is taken because this is a favorable disease." The researchers hope that these data, coupled with other data, will help practitioners understand the various presentations of favorable breast cancer subtypes. They also plan to "identify patients who may need additional multidisciplinary evaluation prior to disposition to a minimalist approach inclusive of observation and limited use of radiation therapy," Perkins said.

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George Perkins
George Perkins, MD, associate professor of the department of radiation oncology at the University of Texas M.D. Anderson Cancer Center in Houston and colleagues presented the findings of the review at the CTRC-AACR San Antonio Breast Cancer Symposium last week. "While mucinous breast cancer is thought to be a disease with a favorable prognosis, our study is the first to identify it as one associated with significant multifocal presentation--a potentially unfavorable aspect with a subtype long thought to be extremely favorable," explained Perkins. "It's imperative that we continue to research personalized treatment options for this subtype and that patients receive their treatment based on actual presentation rather than the assumption that this is always a favorable disease," Perkins said. Other plans for follow- up to this study by Perkins and colleagues will include the evaluation of a subtype of mucinous breast cancer thought to be exceedingly aggressive in hopes of establishing specific screening and treatment guidelines.

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