Douglas M. Ruden

Director at C.S. Mott Center for Human

C.S. Mott Center for Human
Wrong Douglas Ruden?

Last Updated 9/14/2017

General Information


Ph.D.  - Institute of Environmental Health Sciences


Professor of Obstetrics and Gynecology  - Wayne State University

Board of Trustees Member  - Gordon Research Conferences incorporated

Web References  

Epigenetic World Congress 2011

Douglas Ruden, Wayne State University
Using mDIP with antibodies for 5mC or 5hmC in combination with high-throughput sequencing or Illumina Infinium assays, Dr. Ruden examined methylation patterns in killer bees and human neural precursor cells (NPCs). Killer bee brains have 5hmC and there was 90% overlap between regions that were pulled down by either 5mC or 5hmC antibodies. MethylC-seq identified CpG methylation in the exons and CHH methylation in the introns of Killer bees. In human NPCs, hundreds of genes dramatically increased the 5hmC/5mC ratio in CpG islands (assessed by mDIP-Infinium) when grown under 20% oxygen conditions compared to 5% oxygen. Dr. Ruden postulated that 5hmC might be a marker of oxidative stress. He further speculated that because human IVF is routinely done under 20% oxygen, an increase in 5hmC could be responsible for the higher incidence of imprinting disorders in children produced by IVF.

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Flint’s kids “will have to be followed throughout their whole life, and maybe into the next generation or two,� says Douglas Ruden, a neural toxicologist at Wayne State University in Detroit.
A few months of drinking clean water will help bring the kids’ lead levels back down, he says. “But the damage is done.� And it’s permanent.

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