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Christopher K. Breuer

Surgeon

Nationwide Children's Hospital

HQ Phone:  (614) 722-2000

Direct Phone: (614) ***-****direct phone

Email: c***@***.org

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I agree to the Terms of Service and Privacy Policy. I understand that I will receive a subscription to ZoomInfo Community Edition at no charge in exchange for downloading and installing the ZoomInfo Contact Contributor utility which, among other features, involves sharing my business contacts as well as headers and signature blocks from emails that I receive.

Nationwide Children's Hospital

700 Children's Drive

Columbus, Ohio, 43205

United States

Company Description

Named to the Top 10 Honor Roll on U.S. News & World Report's 2016-17 list of "America's Best Children's Hospitals," Nationwide Children's Hospital is America's largest not-for-profit freestanding pediatric healthcare system providing wellness, preventive, diag...more

Find other employees at this company (8,256)

Background Information

Employment History

Associate Professor of Surgery and Director Vascular Tissue Engineering Research

Yale University


Web References(108 Total References)


Cardiovascular and Pulmonary Research Team :: Nationwide Children's Hospital

Christopher K. Breuer, MD
Principal Investigator Christopher K. Breuer, MD General Pediatric Surgery


Having a Baby: Top Doctors - Lifestyle - Columbus Parent - Columbus, OH

Christopher Breuer, Nationwide Children's Hospital, Department of Pediatric Surgery, 700 Children's Drive, Columbus, 614-722-3900


Video Library | Pediatric Colorectal, Motility and Pelvic Reconstruction Conference

Christopher Breuer, MD
Director, Tissue Engineering Program; Attending Pediatric Surgeon, Division of Surgery; Nationwide Children's Hospital, Columbus, OH Christopher Breuer Grant/Research Support - Gunze Ltd., Pall Corp.


A Narrow Focus: Perfecting Tissue Engineered Vascular Grafts - Pediatrics Nationwide

"I think the notion in translational medicine of going from bench to bedside is a little bit flawed," explains Christopher Breuer, MD, pediatric surgeon and principal investigator at Nationwide Children's Hospital.
"In that any time you start to do something in humans, you're really starting all over again at some level." For the last 23 years Dr. Breuer and Toshiharu Shinoka, MD, PhD, co-directors of the Tissue Engineering Program in The Research Institute at Nationwide Children's, have been working together to use tissue engineering techniques in congenital heart surgery. "We were very fortunate," says Dr. Breuer. While you can certainly learn a lot in theoretical and animal studies, when you get to the clinic, there's always a bit of fine tuning, some sense of starting over," Dr. Breuer says. "It might seem counterintuitive to make grafts for mice when you are already doing grafts in the clinic," says Dr. Breuer. In fact, Dr. Breuer explains, "We discovered that you could make the vessels without seeding the scaffolds, but they didn't work as well and were more prone to stenosis. "Macrophages orchestrate the whole process," says Dr. Breuer. In addition to understanding every component of the TEVG process, Dr. Breuer and his team have delved into learning exactly how stenosis forms. Transforming growth factor beta (TGF-) is a cytokine that is involved in many cellular functions, including the regulation of cell growth, proliferation, differentiation and apoptosis. It turns out, TGF- is also integral in the formation of stenosis. "If you block the receptor for TGF-, you can block stenosis," Dr. Breuer says. The grafts formed really well, but the stenosis I was trying to study almost never occurred," explains Dr. Breuer. "This is fairly easy to do," says Dr. Breuer. "And we can mathematically calculate and analyze risks and benefits of altering the amount of cells seeded to reach optimization." Secondly, they plan to address the TGF- pathway using medications. Losartan is a clinically available medication that is already FDA approved for this patient population. The investigational drug SB431542 is still in development and, while promising, is a ways off from FDA-approval. Both drugs show promise in preventing stenosis by altering the TGF- pathway, according to Dr. Breuer. "The investigational drug works really well in the models," says Dr. Breuer. "We know how important the chemical and physical properties of the scaffold are to the whole process and to how much the graft does or does not become stenotic," says Dr. Breuer. "Instead of doing a million experiments, we are letting the computers do some of the heavy lifting," says Dr. Breuer. "Our clinical experience with TEVGs has laid the foundation for extensive research toward the development of the ideal scaffold," says Dr. Breuer.


APSA - Committees

Christopher K. Breuer - Member
Nationwide Children's Hosp-Ohio State Univ


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