Nanovector

Who is Nanovector

NanoVector is a pre-clinical stage therapeutic drug company developing the world's first commercially viable biologic nanoparticle-based therapeuti c drug delivery system. The NanoVector breakthrough technology is being used to develop a family of targeted drugs for late stage metastatic cancers using the plant virus nanoparticle (PVN). Effective targeting of chemotherapy has been highly sought after, because non-targeted chemotherapy causes considerable destruction of normal cells, resulting in severe adverse reactions. With targeting, anticancer agents can concentrate in a cancer cell resulting in extremely high efficacy, while reducing uptake of the anticancer agent by healthy cells; diminishing toxicity to normal cells and thus minimizing unpleasant side effects. The NanoVector drug delivery system is based on an engineered plant virus: Red clover necrotic mosaic virus (RCNMV). It is found in the human food chain, in such foods as cherries, and in some municipal water supplies in temperate climates. RCNMV is harmless to humans, will not replicate in a human cell, and has been found to be of low immunogenicity in testing of mice. It is a soil virus and one of the most robust viruses known. This plant virus has a 36 nanometer protein shell that with a hollow chamber that can be chemically opened and loaded with up to 1000 molecules of a small molecule drug. NanoVector's biologic nanoparticle has evolved for millions of years to become a quintessential intracellular delivery system that overcomes the manufacturing, loading, unloading and targeting technological challenges that plague other nanoscale delivery technologies. In addition, the PVN has two unique characteristics that make it nature's perfect drug delivery system. First and foremost of these unique characteristics, and an inherent property of the virus, is a built-in sensor-actuator system. When the therapeutic agent-carrying PVN enters a cell, it senses a change in chemical environment and automatically unloads its cargo. Therefore the highly toxic ...Read more

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