Dr. Joseph R. Williamson

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  sstrumello.blogspot.com/2007_01_01_archive.html - [Cached Version]
  Published on: 1/1/2007    Last Visited: 7/18/2007  

  "Since this protein is so effective at preventing and reversing vascular leakage, it brings up the possibility that it could prevent cardiovascular disease in both types of diabetes," said Dr. Joseph R. Williamson, M.D., professor of pathology at the Washington University School of Medicine and senior researcher of the 1997 study.

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  A Surprise Discovery That May Help Diabetics - [Cached Version]
  Published on: 7/28/1997    Last Visited: 8/1/2004  

  "It could have a real impact on their lifestyle," said Dr. Joseph Williamson, a researcher with the university's School of Medicine and one of the authors of the study, which was reported in the weekly journal Science.
  ...
  "Perhaps the most surprising finding was that this small protein turns out to have significant biological effects that are very beneficial in terms of preventing or reducing the effects of nerve damage and cardiovascular disease," Williamson said.

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  Accomplishments - [Cached Version]
  Published on: 6/28/2008    Last Visited: 6/28/2008  

  With the retirement of Dr. Joseph Williamson, Director of Research, The Kilo Foundation entered into an agreement with Washington University School of Medicine, Department of Pathology to continue conducting research regarding the causes and appropriate treatment of diabetic complications and cardiovascular disease.

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  Defeat Diabetes: New Theory Explains Diabetic Damage... - [Cached Version]
  Published on: 11/15/2004    Last Visited: 2/2/2005  

  "The metabolic imbalances caused by diabetes are quite complex, and that has made it very difficult to gain acceptance or even consideration of our hypothesis," says senior investigator Joseph Williamson, M.D, a retired pathology faculty member at Washington University School of Medicine in St. Louis.
  ...
  Williamson and his coauthors used in vitro studies of rat retinas to show that both of these conditions decrease the ratio of NAD to NADH in different ways.Hyperglycemia does it by increasing the rate of transformation of NAD to NADH.Hypoxia makes it difficult for cells to turn NADH back to NAD.
  
  In both conditions the increased NADH is recycled back to NAD by processes that produce free radicals, chemically reactive compounds that can damage tissue.Williamson and his coauthors propose that long-term use of these processes causes the damage seen in diabetes.
  
  "The consequences of these different disruptions to NADH recycling are additive--they have the potential to produce much more damage than you might expect if you looked at either one independently," Williamson explains.
  
  Scientists have known for some time that diabetes increases transformation of NAD to NADH by boosting cells' consumption of glucose through a process known as the sorbitol pathway.
  
  Like glycolysis, the sorbitol pathway transforms NAD to NADH, but only at a small fraction of the level of glycolysis.
  ...
  "We've still got quite a bit of convincing to do, but I think people are starting to recognize that this seems to be a major mechanism for producing the free radicals that play such an important role in diabetic complications," Williamson says.

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  Diabetic Complications, NursingDiabetics.com, Your... - [Cached Version]
  Published on: 3/18/2003    Last Visited: 8/12/2006  

  "These observations certainly raise the possibility that (C-peptide) might be useful clinically in preventing the onset and even reversing some of the (diabetic) complications in vessels and nerves," said Dr. Joseph Williamson, professor of pathology at Washington University School of Medicine in St. Louis, and lead researcher of the study.

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  Diabetic damage to eyes, heart, nerves, kidneys may be... - [Cached Version]
  Published on: 10/28/2004    Last Visited: 10/29/2004  

  "The metabolic imbalances caused by diabetes are quite complex, and that has made it very difficult to gain acceptance or even consideration of our hypothesis," says senior investigator Joseph Williamson, M.D, a retired pathology faculty member at Washington University School of Medicine in St. Louis.
  ...
  Williamson and his coauthors used in vitro studies of rat retinas to show that both of these conditions decrease the ratio of NAD to NADH in different ways.Hyperglycemia does it by increasing the rate of transformation of NAD to NADH.Hypoxia makes it difficult for cells to turn NADH back to NAD.
  
  In both conditions the increased NADH is recycled back to NAD by processes that produce free radicals, chemically reactive compounds that can damage tissue.Williamson and his coauthors propose that long-term use of these processes causes the damage seen in diabetes.
  
  "The consequences of these different disruptions to NADH recycling are additive--they have the potential to produce much more damage than you might expect if you looked at either one independently," Williamson explains.
  
  Scientists have known for some time that diabetes increases transformation of NAD to NADH by boosting cells' consumption of glucose through a process known as the sorbitol pathway.
  
  Like glycolysis, the sorbitol pathway transforms NAD to NADH, but only at a small fraction of the level of glycolysis.
  ...
  "We've still got quite a bit of convincing to do, but I think people are starting to recognize that this seems to be a major mechanism for producing the free radicals that play such an important role in diabetic complications," Williamson says.

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  Dr. Williamson's Biography - [Cached Version]
  Published on: 6/28/2008    Last Visited: 6/28/2008  

  Joseph R. Williamson, MDProfessor of PathologyWashington University
  ...
  Dr. Williamson received his MD from Washington University School of Medicine in St. Louis in 1958.He took his internship and residency in pathology at Barnes Hospital in St. Louis and then spent a year as a Research Fellow in Medicine at Harvard University School of Medicine in Boston.On returning to St. Louis, Dr. Williamson became a faculty member of the Department of Pathology at Washington University School of Medicine where he remained until his retirement in 1998 as Professor of Pathology.
  
  Dr. Williamson's professional career has been devoted to elucidating the cause(s) of complications of diabetes.
  ...
  Dr. Williamson has served as an Associate Editor of the journal Diabetes and a member of the Editorial Board of Microvascular Research.He is an active member of several scientific organizations including the American Diabetes Association, European Society for the Study of Diabetes, Association for Research in Vision and Ophthalmology, American Association for the Advancement of Science, and the Federated Society of Experimental Biology and Medicine.

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  Kilo Diabetes Symposium - Faculty - [Cached Version]
  Published on: 4/4/2007    Last Visited: 4/4/2007  

  Joseph R. Williamson, M.D.Professor of Pathology (Retired)Washington University School of Medicine

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  Kilo Diabetes Symposium - Schedule - [Cached Version]
  Published on: 11/18/2006    Last Visited: 4/4/2007  

  Joseph R. Williamson, M.D.

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  New Theory Explains Diabetic Damage To Eyes, Heart,... - [Cached Version]
  Published on: 11/10/2004    Last Visited: 12/6/2004  

  "The metabolic imbalances caused by diabetes are quite complex, and that has made it very difficult to gain acceptance or even consideration of our hypothesis," says senior investigator Joseph Williamson, M.D, a retired pathology faculty member at Washington University School of Medicine in St. Louis."Being able to publish the online appendix finally gave us the room we needed to respond to everyone,s concerns."
  
  Williamson,s theory focuses on the energy-producing compound,s reversible transformation between two forms, nicotinamide adenine dinucleotide ,NAD, and NADH ,NAD plus H, or one atom of hydrogen,.
  ...
  Williamson and his coauthors used in vitro studies of rat retinas to show that both of these conditions decrease the ratio of NAD to NADH in different ways.Hyperglycemia does it by increasing the rate of transformation of NAD to NADH.Hypoxia makes it difficult for cells to turn NADH back to NAD.
  
  In both conditions the increased NADH is recycled back to NAD by processes that produce free radicals, chemically reactive compounds that can damage tissue.Williamson and his coauthors propose that long-term use of these processes causes the damage seen in diabetes.
  
  "The consequences of these different disruptions to NADH recycling are additive--they have the potential to produce much more damage than you might expect if you looked at either one independently," Williamson explains.
  
  Scientists have known for some time that diabetes increases transformation of NAD to NADH by boosting cells, consumption of glucose through a process known as the sorbitol pathway.
  
  Like glycolysis, the sorbitol pathway transforms NAD to NADH, but only at a small fraction of the level of glycolysis.
  ...
  "We,ve still got quite a bit of convincing to do, but I think people are starting to recognize that this seems to be a major mechanism for producing the free radicals that play such an important role in diabetic complications," Williamson says.

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