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Published on: 4/1/2004
Last Visited: 3/14/2008
Pursuing this line of research, NISAD affiliated scientist Prof. Lea Williams is extending her investigations into how schizophrenia affects emotion processing in the brain.
As reported in the January 2001 HeadLines, Prof. Williams and her team have confirmed that the illness causes a dysfunction of normal signaling between the brain?s limbic system and frontal lobes.As the limbic system, including the amygdala, is responsible for emotionally interpreting received impressions, this dysfunction may produce difficulties in the interpretation of emotionally loaded information.
Prof. Williams and her collaborators have now completed two further studies; the first investigated how antipsychotic medication affects the perception of emotion; the second explored the role of limbic/frontal lobe dysfunction and arousal in producing the symptoms of paranoia in schizophrenia.
The effects of medication on emotion processing
For the first study [1], Prof. Williams and collaborators utilised visual scanpaths to assess the effects of antipsychotic medications.
Of 28 schizophrenia subjects, 15 were prescribed the atypical (newer) medication Risperidone, and 13 prescribed the older medication Haloperidol.A control group of healthy unmedicated subjects was also assessed.