Aultman Health Foundation -
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Published on: 8/31/2001
Last Visited: 6/13/2002
Peter P. Vitaliano, PhD, of the University of Washington, reported that while the exact path connecting chronic stress and heart disease may vary from person to person, there appears to be a general pattern - at least in men.
First, chronic stress is associated with psychological distress; factors such as unsatisfactory social supports and poor coping skills may contribute to the link.The psychological distress is associated with poor health habits, such as insufficient exercise and poor diet, and a number of changes in body composition and metabolism that are well-established risk factors for heart disease.Eventually, these changes in body composition and chemistry - known collectively as the metabolic syndrome - produce heart disease.
Evidence for this model comes from a 30-month study of 152 married, older adults conducted by Vitaliano and his colleagues.Eighty of the subjects were caregivers for spouses with Alzheimer disease; previous studies have shown that such caregivers routinely experience numerous physical, emotional and financial stressors.
"The demands of caregiving, coupled with the biological vulnerabilities of aging, put spouse caregivers at increased risk for [coronary heart disease]," making them an ideal population for studying the relationship between heart disease and chronic stress, Vitaliano explained.The other 72 adults, none of them caregivers, served as a comparison group.
The researchers began by examining each subject for attributes that tend to produce psychological distress, such as low income, high exposure to stressors and insufficient coping skills.At the same time, they assessed each subject's level of psychological distress, including depressive symptoms and sleep problems; obtained a self-rating of exercise and diet habits; and looked for indications of metabolic syndrome, including obesity, high blood pressure, and elevated blood levels of cholesterol, insulin and sugar.The researchers repeated all the evaluations 15 to 18 months later.
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One of their strongest findings, Vitaliano pointed out, is that "in men, the pathway from [psychological] distress to the metabolic syndrome was one of the largest pathways from caregiving to [heart disease]."
His team's findings suggest both a direct, immediate relationship between distress and metabolic syndrome, and an indirect, delayed link where distress promotes poor health habits that, over time, exacerbate metabolic syndrome.
Because hormone replacement therapy may affect many of the factors that predispose a woman to heart disease, the investigators broke the women into two groups: those using the therapy and those not using it.Evidence of a connection between chronic stress and heart disease was less clear in either group of women than it was among the men.However, the findings suggest that two different sequences of events link stress to heart disease in women who do and don't take replacement hormones, and that neither sequence in women is the same as that in men.
This article was prepared by Health & Medicine Week editors from staff and other reports.