Dr. Glenn C. Telling

• 
  www.prionetcanada.ca/detail.aspx?menu=12&dt=197211&app= - [Cached Version]
  Published on: 1/26/2006    Last Visited: 12/4/2007  

  Glenn C. Telling of the University of Kentucky, lead investigator of the study said: "We don't know how the infectious prion goes from the central nervous system into the muscle.

• 
  www.cap.org/apps/cap.portal?_nfpb=true&cntvwrPtlt_actio - [Cached Version]
  Published on: 6/27/2003    Last Visited: 7/9/2006  

  At the University of Kentucky, for example, Glenn Telling, PhD, associate professor of microbiology, immunology, and molecular genetics, is making transgenic mice that express cervid (deer or elk) PrP, and also chimeric forms between mouse and cervid.At this point, he and his colleagues are waiting to see when the inoculated mice will develop disease.
  
  They're also interested in the mechanism of prion propagation, which involves using cell culture in vitro approaches as well as transgenic models.Currently Dr. Telling is studying the post-translational processing of PrPc (the normal form of the prion protein) and PrP scrapie (the abnormal form)."It's clear they're very different," he says."So we're trying to define these processing events in the infected and uninfected states."He and his colleagues have recently discovered an enzyme group called calpains, which are calcium-activated cysteine proteases and cleave the scrapie form of PrP."We think this is a major advance," he says."It could open up new therapeutic avenues for inhibiting prion propagation, because if we can inhibit calpains that cleave PrP scrapie, then we can possibly abrogate prion disease.But," he acknowledges, "we need to do a lot of work in vivo to substantiate that, and that's what we're doing at the moment."
  
  Other therapeutic possibilities are more developed, especially immunotherapies.Researchers have developed specific antibodies against PrP and demonstrated, in vitro and in animal models, that certain antibodies can inhibit prion replication."They've shown they could treat animals with specific monoclonal antibodies peripherally, at least, and inhibit the development of clinical features of prion disease," Dr. Telling says.
  ...
  Indeed, along with Drs. Gambetti, Telling, and others, he's well versed in the devilish nature of prions.
  
  "Usually when you study how virus or bacteria behaves in the environment, you're looking at a fairly well-defined entity," he says.

• 
  www.prionetcanada.ca/detail.aspx?menu=12&dt=197209&app= - [Cached Version]
  Published on: 1/31/2006    Last Visited: 12/4/2007  

  The experimental findings "raise the possibility that dietary exposure to prions might occur through meat consumption," writes researcher Glenn Telling at the University of Kentucky, along with six other colleagues.

• 
  www.ctfishnhunt.com/viewtopic.php?t=2017 - [Cached Version]
  Published on: 3/8/2007    Last Visited: 3/8/2007  

  Like the related sheep disease scrapie - though unlike E - CWD spreads from animal to animal, says Glenn Telling of the University of Kentucky at Lexington, US.
  ...
  "We don't know that it is transmitted in the wild by animals eating muscle from infected animals," cautions Telling.
  ...
  "If I were a hunter I would be cautious about eating deer in areas affected," says Telling.But he notes that not much testing of wildlife has been done, and it is not clear how prevalent the infection is.

• 
  08.07.02 Plans to tackle deadly wasting disease sought - [Cached Version]
  Published on: 8/7/2002    Last Visited: 8/7/2002  

  "This field is at once an interesting and frustrating area to work in," said Glenn Telling, a microbiologist from the University of Kentucky and a leading researcher in the mutant protein prions that cause chronic wasting disease."We still know very little about the infectious form of the protein."
  
  The aberrant prions affect an animal's central nervous system, in the latter stages eating microscopic holes in the brain and causing an animal to become emaciated and die.
  
  Although in the same family of contagious diseases as bovine spongiform encephalopathy (BSE, commonly tagged "mad cow disease" by the British press), CWD does not appear able to jump the species barrier and infect humans.
  
  ...
  "The risk to humans from CWD prions remains unclear," Telling said.

• 
  AFAR - [Cached Version]
  Published on: 10/6/2008    Last Visited: 6/19/2008  

  Glenn Telling, Ph.D., Assistant Professor, University of Kentucky Medical Center: "In Vitro Studies of Human Prions"
  
  Glenn/AFAR Research Grant Program for Postdoctoral Fellows

• 
  Alberta (Canada) Elk Commission - [Cached Version]
  Published on: 1/1/2004    Last Visited: 12/7/2005  

  Glen Telling, Ph.D., of the University of Kentucky, will be a close collaborator with Hoover in this effort.

• 
  Argus Leader - News - [Cached Version]
  Published on: 1/31/2006    Last Visited: 1/31/2006  

  Molecular biologist Glenn Telling, a study author, said there is still no evidence of risk to humans and no reason for hunters to change their behavior.
  
  "Of course, this appears to be an emerging disease," he said.

• 
  BCNG Portals Page - [Cached Version]
  Published on: 2/6/2006    Last Visited: 2/7/2006  

  While stressing that was a long way from showing venison was infectious, researcher Glenn Telling of the University of Kentucky said the study showed it could be."If I were to eat venison I wouldn't feel comfortable eating venison from areas where chronic wasting disease is endemic," Telling said in a telephone interview.

• 
  BCNG Portals Page - [Cached Version]
  Published on: 1/27/2006    Last Visited: 1/30/2006  

  While stressing that was a long way from showing venison was infectious, researcher Glenn Telling of the University of Kentucky said the study showed it could be. "If I were to eat venison I wouldn't feel comfortable eating venison from areas where chronic wasting disease is endemic," Telling said in a telephone interview.
  ...
  Telling and colleagues used a well-established method to test the infectivity of venison, by breeding special mice that are susceptible to CWD, then injecting them with brains and muscle tissue from infected deer. The mice became ill and the higher the dose, the worse their disease, they report in Friday's issue of the journal Science."We don't know if people will develop a human prion disease as a result of exposure to CWD but we know people developed prion disease as result of exposure to BSE," Telling said. "Obviously the most likely route of exposure would be via meat and that is why we addressed this." Experts already advise people to take care when handling deer or elk that may have been infected with CWD.The muscle meat of cattle generally has not been found to carry prions but their brains and certain organs do. "It is difficult to predict how prions will behave when they cross species barriers," Telling said.

Page:  1 2 3 4 5