Dr. David Tanne

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  www.benefisheartinstitute.org/pcSites/research-detail.c - [Cached Version]
  Published on: 7/26/2004    Last Visited: 5/11/2005  

  In the current study, a more specific measure of abdominal fat turned out to be a better predictor of stroke than BMI was, lead author Dr. David Tanne told Reuters Health.
  
  "It is not only the presence of body fat that affects stroke risk, but also its distribution," said Tanne, of Tel-Aviv University and the Chami Sheba Medical Center in Tel-Hashomer, Israel.
  
  He and his colleagues report the findings in the American Heart Association's journal Stroke.
  ...
  As trunk fat increases, Tanne explained, so do the risks of each of these disorders.
  
  In addition, he noted, people with abdominal obesity tend to show higher levels of inflammatory substances in the blood.Persistent inflammation in the blood vessels is thought to contribute to artery disease, heart attack and stroke.
  
  BMI has its "shortcomings" when it comes to gauging a person's health risks, Tanne concluded.Simple measures that zero in on abdominal fat -- including waist circumference and the waist-to-hip ratio -- may be better indicators, he said.

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  www.blueberryextract.com/story/triglycerides-stroke-ris - [Cached Version]
  Published on: 12/12/2001    Last Visited: 1/8/2008  

  "To the best of our knowledge, this study is the first to indicate that high triglycerides expose heart disease patients to increased risk for stroke beyond cholesterol," said Dr David Tanne, Director of the stroke unit in the Department of Neurology at Sheba Medical Centre, Tel Hashomer, Israel.
  ...
  "Those [people] have a nearly 30 per cent higher risk of suffering a stroke, after taking into account other risk factors for stroke such as high blood pressure, cigarette smoking or diabetes," said Dr Tanne.
  ...
  "High triglycerides are associated with several abnormalities of the body's clotting systems, which may contribute further to their association with cardiovascular disease," said Dr Tanne.

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  strokeconference.americanheart.org/portal/strokeconfere - [Cached Version]
  Published on: 12/6/2007    Last Visited: 12/6/2007  

  David Tanne, M.D., Tel-hashomer, Israel

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  A P R I A   H E A L T H C A R E  Channels - Heart - [Cached Version]
  Published on: 12/10/2001    Last Visited: 1/5/2002  

  However, this study is the first to identify triglycerides as an independent risk factor for stroke, said study author Dr. David Tanne, director of the stroke unit in the department of neurology at Sheba Medical Center in Israel.
  
  ``We've known for some time about the traditional risk factors, but those don't give us the whole story,'' Tanne said. ``The lesson from our study is, in addition to managing well the bad cholesterol, one should not ignore the triglycerides.''
  
  Further research is needed to determine whether the results apply to people without heart disease, Tanne said.
  
  The findings appear in Tuesday's issue of Circulation.
  
  ...
  But Tanne said earlier studies did not show a clear connection between stroke and triglycerides, probably because researchers focused on fatal strokes and left out other types.
  
  The new study links triglycerides with ischemic stroke and transient ischemic attacks, which are ``mini-strokes.'' Ischemic strokes are the most common form, occurring when an artery feeding the brain is blocked by a clot.
  
  For six to eight years, researchers in Tanne's study followed 11,177 patients with heart disease but no history of stroke.
  
  Those with high levels of triglycerides, or over 200 milligrams per deciliter, had a nearly 30 percent higher risk of stroke.The heart association says the normal level for triglycerides is less than 150.

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  ADVANCE For Respiratory Care Practitioners | Daily... - [Cached Version]
  Published on: 12/10/2001    Last Visited: 2/9/2002  

  "More effective screening and detection of high blood triglycerides and treatments to modify this stroke risk factor could further reduce the clinical and public health burdens of stroke," said Dr. David Tanne, of Sheba Medical Center in Tel Hashomer, Israel.
  
  In the past few years, doctors have learned that drugs that lower blood fats, or lipids, such as cholesterol can also prevent strokes, Tanne told Reuters Health.The precise relationship between blood fats, particularly triglycerides, and stroke has not been clear, however, he said.
  
  In the study, Tanne and his colleagues followed more than 11,000 patients who had coronary heart disease but had never had a stroke or a transient ischemic attack (TIA), or "mini-stroke."
  
  Over the course of six to eight years, 487 individuals had a stroke or a TIA, Tanne and his colleagues report.On average, people who had a stroke or TIA had higher levels of triglycerides and lower levels of HDL cholesterol, the good variety of the blood fat, he and his colleagues report in the Dec. 11 issue of Circulation: Journal of the American Heart Association.
  
  Acid Reflux Often Precedes Coughing or Wheezing in Asthmatics In asthmatic patients, gastroesophageal reflux frequently causes coughing; rarely does coughing, through increased abdominal pressure, cause reflux of acid.
  
  This finding comes from a study published in the December issue of the journal Gut.

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  ADVANCE For Respiratory Care Practitioners | Daily... - [Cached Version]
  Published on: 6/6/2002    Last Visited: 6/6/2002  

  "More effective screening and detection of high blood triglycerides and treatments to modify this stroke risk factor could further reduce the clinical and public health burdens of stroke," said Dr. David Tanne, of Sheba Medical Center in Tel Hashomer, Israel.
  
  In the past few years, doctors have learned that drugs that lower blood fats, or lipids, such as cholesterol can also prevent strokes, Tanne told Reuters Health.The precise relationship between blood fats, particularly triglycerides, and stroke has not been clear, however, he said.
  
  In the study, Tanne and his colleagues followed more than 11,000 patients who had coronary heart disease but had never had a stroke or a transient ischemic attack (TIA), or "mini-stroke."
  
  Over the course of six to eight years, 487 individuals had a stroke or a TIA, Tanne and his colleagues report.On average, people who had a stroke or TIA had higher levels of triglycerides and lower levels of HDL cholesterol, the good variety of the blood fat, he and his colleagues report in the Dec. 11 issue of Circulation: Journal of the American Heart Association.
  
  Acid Reflux Often Precedes Coughing or Wheezing in Asthmatics In asthmatic patients, gastroesophageal reflux frequently causes coughing; rarely does coughing, through increased abdominal pressure, cause reflux of acid.
  
  This finding comes from a study published in the December issue of the journal Gut.

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  Abdominal fat tied to higher stroke risk - Yahoo! News - [Cached Version]
  Published on: 5/11/2005    Last Visited: 5/11/2005  

  In the current study, a more specific measure of abdominal fat turned out to be a better predictor of stroke than BMI was, lead author Dr. David Tanne told Reuters Health.
  
  "It is not only the presence of body fat that affects stroke risk, but also its distribution," said Tanne, of Tel-Aviv University and the Chami Sheba Medical Center in Tel-Hashomer, Israel.
  
  He and his colleagues report the findings in the American Heart Association's journal Stroke.
  ...
  As trunk fat increases, Tanne explained, so do the risks of each of these disorders.
  
  In addition, he noted, people with abdominal obesity tend to show higher levels of inflammatory substances in the blood.Persistent inflammation in the blood vessels is thought to contribute to artery disease, heart attack and stroke.
  
  BMI has its "shortcomings" when it comes to gauging a person's health risks, Tanne concluded.Simple measures that zero in on abdominal fat -- including waist circumference and the waist-to-hip ratio -- may be better indicators, he said.

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  AccessMedicine: Search Results - [Cached Version]
  Published on: 12/11/2001    Last Visited: 2/14/2003  

  "High triglycerides are associated with ischemic stroke and transient ischemic attacks (TIA)," says David Tanne, M.D., lead author of the study."To the best of our knowledge, this study is the first to indicate that high triglycerides expose heart disease patients to increased risk for stroke beyond cholesterol."
  
  In light of this finding, healthcare providers should include triglycerides as part of their global risk assessment for stroke in all individuals and know that people can have elevated triglycerides even if their cholesterol is normal, says Tanne, who is director of the stroke unit, department of neurology, at Sheba Medical Center, Tel Hashomer, Israel.
  
  "More effective screening and detection of high blood triglycerides and treatments to modify this stroke risk factor could further reduce the health burdens of stroke," says Tanne.
  
  Stroke is the third-largest cause of death in the United States after coronary heart disease and all forms of cancer.It is a leading cause of serious, long-term disability in the United States.The most common type of stroke, accounting for about 80 percent of all cases, is ischemic stroke, which is caused by interruption of the blood supply to the brain.
  
  Major risk factors for stroke include heredity, smoking, increasing age, high blood pressure, diabetes, heart disease, and sickle cell anemia.High blood cholesterol, physical inactivity, obesity and overweight are secondary risk factors.
  ...
  "Our main finding in this study is that elevated blood triglycerides increase a person's risk of suffering an ischemic stroke," Tanne says."Those with high blood triglycerides (over 200 mg/dL) have a nearly 30 percent higher risk of suffering a stroke, after taking into account other risk factors for stroke such as high blood pressure, cigarette smoking or diabetes."
  
  A secondary finding was that individuals with high HDL (high density lipoprotein, the good cholesterol) were less likely to have a stroke.
  
  Triglycerides are found in fats.Excess levels of triglycerides increase concentrations of two types of fat particles: chylomicrons and very-low-density lipoproteins.
  ...
  These fat particles may contribute to the fatty deposits that obstruct blood flow, increasing the risk for ischemic stroke, says Tanne.
  
  Triglyceride levels are measured by a standard cholesterol blood test.The link between triglycerides and stroke is still under investigation, says Tanne."However, in addition to the direct atherogenic effect of triglycerides, these lipids appear to be a marker of a series of other changes that could worsen atherosclerosis or cause blood clots.High triglycerides are associated with several abnormalities of the body's clotting systems, which may contribute further to their association with cardiovascular disease."
  
  Further studies are required to see if a similar link between blood triglycerides and stroke exists in individuals without heart disease.If so, specific drugs or drug combinations for lowering blood lipids may need to be used to prevent strokes among those with high blood triglycerides, says Tanne.
  
  The American Heart Association recommends the following triglycerides guidelines: Normal range is less than 150 mg/dL; borderline-high is 150 to 199 mg/dL; high is 200 to 499 mg/dL; and very high is 500 mg/dL or higher.Following a low-fat diet, exercising and treating overweight can lower triglyceride levels.

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  Age Management Medicine News Letter - 07.10.06 - [Cached Version]
  Published on: 7/11/2006    Last Visited: 3/12/2009  

  Dr. David Tanne of Sheba Medical Center and Tel Aviv University and colleagues note that although CRP is an important predictor of cardiovascular disease, few prospective data are available on its association with ischemic stroke risk in such patients.
  ...
  "These findings," Dr. Tanne told Reuters Health, "show that we can better identify patients at high risk of stroke using this blood test (CRP), but whether one can prevent strokes by lowering the levels of this marker of inflammation, needs yet to be determined."

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  Alternative Medicine-Alternative Medical Systems - [Cached Version]
  Published on: 8/21/2003    Last Visited: 8/21/2003  

  "High triglycerides are associated with ischemic stroke and transient ischemic attacks (TIA)," says David Tanne, M.D., lead author of the study.
  
  "To the best of our knowledge, this study is the first to indicate that high triglycerides expose heart disease patients to increased risk for stroke beyond cholesterol."
  
  In light of this finding, healthcare providers should include triglycerides as part of their global risk assessment for stroke in all individuals and know that people can have elevated triglycerides even if their cholesterol is normal, says Tanne, who is director of the stroke unit, department of neurology, at Sheba Medical Center, Tel Hashomer, Israel.
  
  "More effective screening and detection of high blood triglycerides and treatments to modify this stroke risk factor could further reduce the health burdens of stroke," says Tanne.
  ...
  This research better clarifies the association between lipids and stroke because it looks at triglycerides independently in a large group of patients, says Tanne.
  
  "Our main finding in this study is that elevated blood triglycerides increase a person's risk of suffering an ischemic stroke," Tanne says.
  ...
  These fat particles may contribute to the fatty deposits that obstruct blood flow, increasing the risk for ischemic stroke, says Tanne.
  
  Triglyceride levels are measured by a standard cholesterol blood test.
  
  The link between triglycerides and stroke is still under investigation, says Tanne.
  
  "However, in addition to the direct atherogenic effect of triglycerides, these lipids appear to be a marker of a series of other changes that could worsen atherosclerosis or cause blood clots.
  
  High triglycerides are associated with several abnormalities of the body's clotting systems, which may contribute further to their association with cardiovascular disease."
  
  Further studies are required to see if a similar link between blood triglycerides and stroke exists in individuals without heart disease.If so, specific drugs or drug combinations for lowering blood lipids may need to be used to prevent strokes among those with high blood triglycerides, says Tanne.

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