Dr. Toshihiro Tanaka

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  www.researchsea.com/html/article.php/aid/4395/cid/1/res - [Cached Version]
  Last Visited: 7/5/2009  

  Nakagawa took note of a paper produced as part of a joint research project between Toshihiro Tanaka, group director at the RIKEN Center for Genomic Medicine, and an Osaka University group, in which it was reported that the substitution of a single base in the MIAT gene with another particular base increases the probability of the onset of myocardial infarction by a factor of 1.38.
  ...
  Although Tanaka and his colleagues discovered the gene earlier, Nakagawa made his discovery before MIAT had been registered in the database, so the gene has been given two names.
  ...
  "I read the paper by Tanaka and his colleagues and became confident that the Gomafu RNA does something important.

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  bg-jp-symposium.com/?op=page&lan=BG&id=89 - [Cached Version]
  Last Visited: 7/7/2009  

  Toshihiro Tanaka, M.D., Ph.D., Group Director: Laboratory for Cardiovascular Diseases,Center for Genomic Medicine,The Institute of Physical and Chemical Research (RIKEN)

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  Bnn, Bulgarian news network - online news agency \... - [Cached Version]
  Published on: 5/5/2004    Last Visited: 5/5/2004  

  "We have identified...a gene that is associated with susceptibility to myocardial infarction," Dr Toshihiro Tanaka of the Institute of Physical and Chemical Research (RIKEN) in Tokyo, said in an e-mail interview.
  ...
  Tanaka and his team suspect the genetic variation affects the amount of LTA that is secreted and the degree of inflammation that occurs.
  
  "Decreased expression of galectin-2 might be protective against the risk of MI, so drugs that can reduce the function of galectin-2 can be therapeutic," added Tanaka, who reported his findings in the science journal Nature.
  ...
  Galectin-2 is not secreted into the blood but Tanaka said levels of the protein can be examined from DNA of white blood cells in blood.
  
  He believes the discovery of the genetic variation could lead to other risk factors for heart attack and increase understanding about why it occurs.
  
  "We are thinking of the possibility that galectin-2 might play a key role in the inflammation process of myocardial infarction," he added. /Reuters

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  Gene Mutation May Up Your Risk of Heart Attack - [Cached Version]
  Published on: 10/20/2003    Last Visited: 5/26/2004  

  So, drugs that can reduce the function of galectin-2 can be therapeutic agents," said study co-author Dr. Toshihiro Tanaka, Laboratory Head at The Institute of Physical and Chemical Research in Tokyo.
  ...
  Tanaka added this is not "the" single gene that causes heart attacks, so even people who don't have it could still be at risk.
  
  "Unlike monogenic diseases, including cystic fibrosis or Duchenne muscle dystrophy, in which case mutation equals disease-causing, the causes of [other] common diseases [such as heart disease] are a combination of environmental factors as well as several to many genetic factors," Tanaka said.
  ...
  SOURCES: Toshihiro Tanaka, M.D., Ph.D., Laboratory Head, The Institute of Physical and Chemical Research, Tokyo; Stephen Siegel, M.D., cardiologist, New York University Medical Center, and clinical assistant professor, New York University School of Medicine, New York City; May 6, 2004, Nature

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  Gene Mutation May Up Your Risk of Heart Attack-WCSY... - [Cached Version]
  Published on: 10/2/2003    Last Visited: 5/7/2004  

  So, drugs that can reduce the function of galectin-2 can be therapeutic agents," said study co-author Dr. Toshihiro Tanaka, Laboratory Head at The Institute of Physical and Chemical Research in Tokyo.
  ...
  Tanaka added this is not "the" single gene that causes heart attacks, so even people who don't have it could still be at risk.
  
  "Unlike monogenic diseases, including cystic fibrosis or Duchenne muscle dystrophy, in which case mutation equals disease-causing, the causes of [other] common diseases [such as heart disease] are a combination of environmental factors as well as several to many genetic factors," Tanaka said.

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  Genetic Variation for Heart Attack Risk Found - News - [Cached Version]
  Published on: 10/7/2006    Last Visited: 10/7/2006  

  "We have identified...a gene that is associated with susceptibility to myocardial infarction," Dr Toshihiro Tanaka of the Institute of Physical and Chemical Research (RIKEN) in Tokyo, said in an e-mail interview.
  ...
  Tanaka and his team suspect the genetic variation affects the amount of LTA that is secreted and the degree of inflammation that occurs.
  
  "Decreased expression of galectin-2 might be protective against the risk of MI, so drugs that can reduce the function of galectin-2 can be therapeutic," added Tanaka, who reported his findings in the science journal Nature.
  ...
  Galectin-2 is not secreted into the blood but Tanaka said levels of the protein can be examined from DNA of white blood cells in blood.
  
  He believes the discovery of the genetic variation could lead to other risk factors for heart attack and increase understanding about why it occurs.
  
  "We are thinking of the possibility that galectin-2 might play a key role in the inflammation process of myocardial infarction," he added.

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  Genetic variation for heart attack risk found - [Cached Version]
  Published on: 5/5/2004    Last Visited: 5/7/2004  

  "We have identified...a gene that is associated with susceptibility to myocardial infarction," Dr Toshihiro Tanaka of the Institute of Physical and Chemical Research (RIKEN) in Tokyo, said in an e-mail interview.
  ...
  Tanaka and his team suspect the genetic variation affects the amount of LTA that is secreted and the degree of inflammation that occurs.
  
  "Decreased expression of galectin-2 might be protective against the risk of MI, so drugs that can reduce the function of galectin-2 can be therapeutic," added Tanaka, who reported his findings in the science journal Nature.
  ...
  Galectin-2 is not secreted into the blood but Tanaka said levels of the protein can be examined from DNA of white blood cells in blood.
  
  He believes the discovery of the genetic variation could lead to other risk factors for heart attack and increase understanding about why it occurs.
  
  "We are thinking of the possibility that galectin-2 might play a key role in the inflammation process of myocardial infarction," he added.

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  Heart Attack Genes Fingered - Health and medical... - [Cached Version]
  Published on: 11/1/2003    Last Visited: 9/4/2004  

  So, drugs that can reduce the function of galectin-2 can be therapeutic agents," said study co-author Dr. Toshihiro Tanaka, Laboratory Head at The Institute of Physical and Chemical Research in Tokyo.
  ...
  Tanaka added this is not "the" single gene that causes heart attacks, so even people who don't have it could still be at risk.
  
  "Unlike monogenic diseases, including cystic fibrosis or Duchenne muscle dystrophy, in which case mutation equals disease-causing, the causes of [other] common diseases [such as heart disease] are a combination of environmental factors as well as several to many genetic factors," Tanaka said.
  ...
  SOURCES: Toshihiro Tanaka, M.D., Ph.D., Laboratory Head, The Institute of Physical and Chemical Research, Tokyo; Stephen Siegel, M.D., cardiologist, New York University Medical Center, and clinical assistant professor, New York University School of Medicine, New York City; May 6, 2004, Nature

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  International Society for Biological and Environmental... - [Cached Version]
  Published on: 1/1/2007    Last Visited: 2/5/2007  

  Toshihiro Tanaka, RIKEN, Japan

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  Network Of Care - [Cached Version]
  Published on: 5/6/2004    Last Visited: 5/29/2004  

  So, drugs that can reduce the function of galectin-2 can be therapeutic agents," said study co-author Dr. Toshihiro Tanaka, Laboratory Head at The Institute of Physical and Chemical Research in Tokyo.
  ...
  Tanaka added this is not "the" single gene that causes heart attacks, so even people who don't have it could still be at risk.
  
  "Unlike monogenic diseases, including cystic fibrosis or Duchenne muscle dystrophy, in which case mutation equals disease-causing, the causes of [other] common diseases [such as heart disease] are a combination of environmental factors as well as several to many genetic factors," Tanaka said.

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