Barry P. Sleckman

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  www.pemphigus.org/news/index.php?option=com_content&vie - [Cached Version]
  Published on: 5/4/2009    Last Visited: 5/13/2009  

  Chair: Barry P. Sleckman, Washington University School of Medicine, AAI Education Committee
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  Barry P. Sleckman, Associate Professor, Washington University School of Medicine, Introduction
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  Chair: Barry P. Sleckman, Washington University School of Medicine, AAI Education Committee
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  Barry P. Sleckman, Associate Professor, Washington University School of Medicine, Introduction

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  medcentertoday.com/news_list.php?PHPSESSID=4fub0c23cq74 - [Cached Version]
  Last Visited: 8/3/2008  

  Barry P. Sleckman, M.D., Ph.D., associate professor of pathology and immunology, has been named director of the Division of Laboratory and Genomic Medicine at Washington Univ. School of Medicine in St. Louis.

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  www.childrensdiscovery.org/tabid/76/itemid/140/Fifteen- - [Cached Version]
  Published on: 1/1/2009    Last Visited: 9/16/2009  

  His mentor is Barry Sleckman, MD, PhD., Professor of Pathology. His work is being carried out within the McDonnell Pediatric Cancer Center.

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  www.news-line.com/commander.lasso?-Search=Action&-Table - [Cached Version]
  Published on: 10/24/2008    Last Visited: 6/17/2009  

  "It's also interesting to note that the cell sees the genetic material of some invaders, such as DNA viruses, as damaged DNA," says senior author Barry Sleckman, MD, PhD, director of the Division of Laboratory and Genomic Medicine and an expert in DNA repair.
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  "This explains why the lymphocyte counts in these patients drop so sharply," Sleckman says.
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  Sleckman wanted to examine the implications of DNA breaks in lymphocytes. In a cell line developed in his lab, researchers induced double-stranded breaks in lymphocyte DNA using the same enzymes the cells normally use to create the breaks. They then analyzed the genes activated as a result.
  
  As expected, the breaks turned on two groups of genes: one, headed by the p53 protein, pushes the cell toward self-destruction; the other, headed by the NFKappa-B proteins, pushes for survival of the cell and repair of the damaged DNA. These groups of genes are normally activated in any cell that experiences DNA damage.
  
  But Sleckman and his colleagues also found several lymphocyte-specific genes activated by the breaks.
  
  "Several of these genes are involved in the migration and homing of lymphocytes," says Sleckman.
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  "It's entirely possible that some of these breaks are activating genetic mechanisms that are unrelated to DNA repair or cell survival, like the mechanisms we identified in lymphocytes," says Sleckman.

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  www.eurekalert.org/pub_releases/2008-10/wuso-sss102008. - [Cached Version]
  Published on: 10/20/2008    Last Visited: 10/21/2008  

  "It's also interesting to note that the cell sees the genetic material of some invaders, such as DNA viruses, as damaged DNA," says senior author Barry Sleckman, M.D., Ph.D, director of the Division of Laboratory and Genomic Medicine and an expert in DNA repair.
  ...
  "This explains why the lymphocyte counts in these patients drop so sharply," Sleckman says.
  ...
  Sleckman wanted to examine the implications of DNA breaks in lymphocytes. In a cell line developed in his lab, researchers induced double-stranded breaks in lymphocyte DNA using the same enzymes the cells normally use to create the breaks. They then analyzed the genes activated as a result.
  
  As expected, the breaks turned on two groups of genes: one, headed by the p53 protein, pushes the cell toward self-destruction; the other, headed by the NFKappa-B proteins, pushes for survival of the cell and repair of the damaged DNA. These groups of genes are normally activated in any cell that experiences DNA damage.
  
  But Sleckman and his colleagues also found several lymphocyte-specific genes activated by the breaks.
  
  "Several of these genes are involved in the migration and homing of lymphocytes," says Sleckman.
  ...
  "It's entirely possible that some of these breaks are activating genetic mechanisms that are unrelated to DNA repair or cell survival, like the mechanisms we identified in lymphocytes," says Sleckman.

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  www.childrensdiscovery.org/tabid/64/itemid/154/Breaking - [Cached Version]
  Published on: 7/1/2009    Last Visited: 9/16/2009  

  Dr. Bednarski's mentor is Barry Sleckman, MD, PhD, who directs the Division of Laboratory and Genomic Medicine.

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  2008 AAI Advanced Course in Immunology - [Cached Version]
  Published on: 1/1/2008    Last Visited: 10/1/2009  

  Barry P. Sleckman, Washington University School of Medicine

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  ASCI - [Cached Version]
  Published on: 8/3/2003    Last Visited: 3/19/2004  

  Barry Sleckman
  
  Washington University School of Medicine

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  Bioinformatics News Jul 2008: bioinformatics,... - [Cached Version]
  Published on: 7/1/2008    Last Visited: 2/12/2009  

  Sleckman named director of Division of Laboratory and Genomic Medicine July 21, 2008 -- Barry P. Sleckman, M.D., Ph.D., associate professor of pathology and immunology, has been named director of the Division of Laboratory and Genomic Medicine at Washington University School of Medicine in St. Louis. (Mon, 21 Jul 2008 22:22:09 GMT)

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  Burroughs Wellcome Fund: Biomedical Sciences: Career... - [Cached Version]
  Published on: 7/7/2006    Last Visited: 7/31/2008  

  Barry P. Sleckman, M.D., Ph.D.Postdoctoral Institution: Harvard Medical SchoolFaculty Institution: Washington University School of Medicine

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