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Published on: 1/1/2006
Last Visited: 8/5/2007
"There's been a lot of progress in the treatment of this disease even in the last 18 months," says Dr. Stephen G. Schwartz, a board-certified ophthalmologist at the Bascom Palmer Eye Institute in Naples.
There have been several major advances over the last two years in the treatment of the "wet" form of AMD, so named because it involves bleeding in the macular, the central part of the retina."Dry" AMD, which accounts for about 80 percent of the cases, progresses more slowly.
In December 2004, the FDA approved a drug called Macugen, which creates a chemical blockade of leaking blood vessels and "immediately changed how this disease was treated," according to Schwartz.Then came Lucentis, a competitor to Macugen that has shown promising results in clinical trials but awaits FDA approval.Both are injected into the eye.
"The third major step forward happened in the last 18 months," Schwartz says."Avastin, a cancer drug approved by the FDA to treat cancer intravenously, was found to have some efficacy in treating macular degeneration."
Avastin's effectiveness was discovered by researchers at Bascom Palmer's headquarters at the University of Miami Miller School of Medicine.
"They tried putting the drug in the eye, even though it was never intended to go in the eye, and it was more successful than anybody had expected," Schwartz says.