Dr. Steven Rosenberg

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  dissidentvoice.org/2009/07/monsanto-a-contemporary-east - [Cached Version]
  Published on: 3/20/2008    Last Visited: 9/7/2009  

  That is why Steven Rosenberg, cancer researcher of the National Cancer Institute, says, "The ethics of business and the ethics of science do not mix well."

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  www.technologyreview.com/Biotech/17064/ - [Cached Version]
  Published on: 9/15/2007    Last Visited: 9/15/2007  

  But "nobody has figured out a way to make cancer vaccines work," says Steven Rosenberg, head of tumor immunology in the National Cancer Institute's Center for Cancer Research.
  
  Rosenberg's group and another in southern California are trying a new approach by going after one of the most important cells in the immune system, the T cell.
  ...
  Baltimore and Rosenberg are both using gene therapy to mobilize T cells against cancer.
  ...
  Rosenberg is currently conducting a clinical trial using a T cell receptor gene for melanoma in patients with advanced disease.Patients' blood is drawn, their T cells are removed, incubated with the virus, then replaced.Rosenberg declined to discuss his results because it would jeopardize upcoming publication in a scientific journal.But he hopes to start clinical trials on other cancers soon: his group has isolated the receptor for an antigen made in large quantities in half of all common cancers, including those of the breast, lung, and prostate.

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  www.altriagroup.co.uk/docroot/NWS/content/NWS_1_1x_Gene - [Cached Version]
  Published on: 8/31/2006    Last Visited: 5/30/2007  

  Researchers led by Steven Rosenberg, MD, PhD, a noted expert in cancer immunology, wanted to find a way to make normal immune system cells behave like these hard-to-find natural tumor fighters.

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  www.gordon-ermer.com/2006/09/more-on-gene-therapy.html - [Cached Version]
  Published on: 9/1/2006    Last Visited: 10/9/2007  

  I watched Dr. Stephen Rosenberg of the National Cancer Institute on Good Morning America today.As I noted in the blog yesterday, Dr. Rosenberg's miraculous gene therapy cured two out of seventeen potentially fatal melanoma cases.In his interview this morning, Dr. Rosenberg explained that the treatment was administered two years ago, and since then his team has strengthened the treatment and moreover has adapted the therapy to fight other potentially fatal cancers.He is waiting for Food and Drug Administration approval to test the therapy on other types of cancer.

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  www.thislife.org/pages/descriptions/04/262.html - [Cached Version]
  Published on: 4/2/2004    Last Visited: 3/6/2007  

  Ira talks with Dr. Stephen Rosenberg of the National Cancer Institute about a cancer patient of his who spontaneously healed.

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  www.losteye.com/message_forum/viewtopic.php?t=1936&sid= - [Cached Version]
  Published on: 1/14/2003    Last Visited: 12/9/2007  

  Researchers led by Steven Rosenberg, MD, PhD, a noted expert in cancer immunology, wanted to find a way to make normal immune system cells behave like these hard-to-find natural tumor fighters.
  ...
  But Dr. Steven Rosenberg, the cancer institute researcher who led the melanoma study, said no therapy of this sort has ever worked this well before.He has been tinkering with various gene therapy techniques since 1990, when he led the first study showing that it was possible to transfer cancer-fighting traits into the genes of patients.Despite early promise, none of those efforts bore fruit until now.
  
  "This is certainly highly experimental, but this is proof of the principle that you can use genetic engineering to treat cancer patients," Rosenberg said in a telephone interview.
  
  He contends that his laboratory has been refining the latest technique since the patients were treated nearly two years ago, and he is seeking U.S. Food and Drug Administration approval next month to conduct a new round of experiments.
  ...
  Rosenberg said that the receptors used in the initial experiment were barely adequate to the task."We now have receptors that are 100 times as powerful," he said.His lab also has isolated different receptors for other types of cancer cells: those of the breast, lung, liver and esophagus and some types of solid tumors known as sarcomas.
  
  "This potentially will give us a way to treat very common cancers," he said.
  
  Dr. Patrick Hwu, a former colleague of Rosenberg and now chairman of the melanoma department at the M.D.
  ...
  Rosenberg insists that his study represents a significant advance."Of course, people will make claims, especially companies.But none of the other gene therapy attempts have worked," he said.

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  Article - [Cached Version]
  Published on: 10/1/2002    Last Visited: 10/1/2002  

  Dr. Steven Rosenberg, a veteran scientist at the National Cancer Institute, has successfully treated melanoma patients by taking from them a sample of vital white blood cells.
  
  Those cells were cultured in the laboratory and multiplied to numbers impossible for the human body to produce on its own.The cells then were treated to become cancer-destroying super warriors.These altered constituents then were re-introduced into the patients.
  
  All 13 patients had exhausted medicine's most sophisticated standard therapies, including surgery to remove the primary tumor.
  
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  "Basically, what we have found is a new way to grow cells outside of a patient," Rosenberg said.The full results of his study are reported in the current issue of the journal Science.
  
  Rosenberg and his team harnessed the human immune system, using the body's own cancer-fighting capabilities, but multiplied by dramatic orders of magnitude.
  
  T-cells used
  
  The scientists amplified T-cells, a vital population of white blood cells manufactured in the thymus gland.These cells are central to the body's ability to orchestrate an immune response against a variety of diseases, including infections.
  
  Culturing techniques allowed the scientists to generate billions of new cancer-recognizing T-cells.
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  The new approach is able to work, Rosenberg said, because the immune cells recognize tumors as foreign.
  
  Fellow cancer researchers are regarding Rosenberg's development with keen interest because of the elusiveness, so far, in coaxing the immune system into killing cancers.
  
  ...
  Rosenberg, a pioneer in cancer immunotherapy, has had limited success with previous attempts to spur the body into mounting an assault on cancer.He is considered by many to be one of the founders of cancer immunotherapy.
  
  For years, he and others have tried to prompt an immune response to attack cancers, producing either transient results, or nothing at all.
  
  The new technique overcomes a key difficulty: getting enough immune system cells to react against the cancer.
  
  Rosenberg said 90 percent of the activated T-cells are primed against the cancer and can sustain the attack over time.
  
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  Cancer Decisions - Free Newsletter -November 21, 2004 - [Cached Version]
  Published on: 11/21/2004    Last Visited: 8/27/2006  

  This was a "hot" therapy in the 1980s and early 1990s, primarily because of the advocacy of Steven Rosenberg, MD, of the National Cancer Institute (Rosenberg 1993).

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  FEHBlog: September 2006 - [Cached Version]
  Published on: 9/1/2006    Last Visited: 10/9/2007  

  I watched Dr. Stephen Rosenberg of the National Cancer Institute on Good Morning America today.As I noted in the blog yesterday, Dr. Rosenberg's miraculous gene therapy cured two out of seventeen potentially fatal melanoma cases.In his interview this morning, Dr. Rosenberg explained that the treatment was administered two years ago, and since then his team has strengthened the treatment and moreover has adapted the therapy to fight other potentially fatal cancers.He is waiting for Food and Drug Administration approval to test the therapy on other types of cancer.

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  Gene therapy used to zap melanoma / Tests hailed as... - [Cached Version]
  Published on: 9/1/2006    Last Visited: 9/1/2006  

  But Dr. Steven Rosenberg, the cancer institute researcher who led the melanoma study, said no therapy of this sort has ever worked this well before.He has been tinkering with various gene therapy techniques since 1990, when he led the first study showing that it was possible to transfer cancer-fighting traits into the genes of patients.Despite early promise, none of those efforts bore fruit until now.
  
  "This is certainly highly experimental, but this is proof of the principle that you can use genetic engineering to treat cancer patients," Rosenberg said in a telephone interview.
  
  He contends that his laboratory has been refining the latest technique since the patients were treated nearly two years ago, and he is seeking U.S. Food and Drug Administration approval next month to conduct a new round of experiments.
  ...
  Rosenberg said that the receptors used in the initial experiment were barely adequate to the task."We now have receptors that are 100 times as powerful," he said.His lab also has isolated different receptors for other types of cancer cells: those of the breast, lung, liver and esophagus and some types of solid tumors known as sarcomas.
  
  "This potentially will give us a way to treat very common cancers," he said.
  
  Dr. Patrick Hwu, a former colleague of Rosenberg and now chairman of the melanoma department at the M.D.
  ...
  Rosenberg insists that his study represents a significant advance."Of course, people will make claims, especially companies.But none of the other gene therapy attempts have worked," he said.

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