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Published on: 3/27/2008
Last Visited: 7/19/2008
Azra Raza, MD
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"A derivative of the drug thalidomide, Revlimid, is FDA-approved for the treatment of transfusion-dependent anemia in patients with lower risk MDS who carry a specific chromosomal abnormality," says Azra Raza, M.D., attending physician and head of the MDS program, St. Vincent's Comprehensive Cancer Center, senior and corresponding author of the study.
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"The use of genetic testing in MDS to determine how individuals will respond to specific drug therapies not only keeps patients from getting a drug like Revlimid that won't benefit them, but also means they won't be exposed to its potentially toxic side effects," says Dr. Raza.
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Backed by an outstanding basic research laboratory, the program is headed by Azra Raza, M.D., regarded as one of the world's leading hematologists and experts on MDS.A hallmark of the program is a repository containing approximately 50,000 tissue samples of MDS and acute myeloid leukemia (AML) patients collected by Dr. Raza.A number of exciting, cutting edge clinical trials are open for all stages of MDS and AML patients, including those with early stage disease who are being offered treatment with herbs and other natural substances.Dr. Raza serves on numerous national and international panels as a reviewer, consultant and advisor.
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St. Vincent's Comprehensive Cancer Center (SVCCC), a center of excellence in hematology oncology, adds Azra Raza, MD, as attending physician in Medical Oncology.Dr. Raza is an internationally recognized specialist in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML).The addition of Dr. Raza to its staff is part of an initiative to build SVCCC as a cancer center with subspecialty oncology programs.
Dr. Raza will direct the study and treatment of MDS, which refers to a group of conditions caused by abnormal blood-forming cells of the bone marrow.Considered a relatively rare cancer, 15,000-20,000 new cases are diagnosed annually in the United States.In about 3 out of 10 cases, the MDS will become AML.
Dr. Raza treats 500 to 600 AML and MDS patients from around the United States who travel to receive cutting edge individualized therapies based on molecular and genetic studies of their bone marrows.The MDS program at SVCCC will be unique, in that Dr. Raza has built a national referral base for MDS treatment and research with a large enough population for patients to participate in meaningful clinical trials.
Most recently Dr. Raza was chief, Hematology Oncology and professor of medicine at the University of Massachusetts, and UMass Memorial Medical Center, Worchester, MA. Prior to that appointment, she established the most clinically active and well-funded basic research programs in the United States at Rush Cancer Institute, Chicago, IL, for studying MDS and the leukemias arising from them.
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