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Published on: 6/12/2008
Last Visited: 6/17/2008
Susannah Rankin, Ph.D.Oklahoma Medical Research Foundation
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Susannah Rankin, Ph.D.Susannah Rankin, Ph.D., received a doctorate in molecular microbiology from Tufts University School of Medicine in 1995.She pursued postdoctoral studies at Harvard Medical School from 1995 to 2006, then joined the staff of the Oklahoma Medical Research Foundation as an assistant member in the department of molecular, cell and developmental biology.Dr. Rankin wants to understand the intricate molecular mechanisms that govern how dividing cells parcel out chromosomes to their daughters.Before cells reproduce, they duplicate their DNA.These chromosome copies remain attached to the originals until they are ready to be pulled apartâ€"with a copy of each chromosome going to each of the daughter cells.This cohesion of chromosome copies prior to separation is crucial: defects in the proteins that hold these sister chromosomes together can lead to developmental disorders and possibly cancer.During her postdoctoral fellowship, Dr. Rankin identified a new protein, called sororin, that regulates sister chromosome cohesion.Now, using a combination of genetic, biochemical and cell biological techniques, Dr. Rankin will try to determine when, where and how sororin helps hold chromosomes together, and she will explore how defects in other cohesion-related proteins derail the process.