Research attempts to better evaluate colorectal cancer -
[Cached Version]
Published on: 2/7/2003
Last Visited: 2/8/2003
"If you have a patient who has very little risk of having cancer beyond the primary organ which is going to be removed, it doesn't make much sense to give that person aggressive chemotherapy or radiation therapy," said Dr. John F. Potter, director of the United States Military Cancer Institute."These things have some toxicity in and of themselves."
To help determine what stage a patient's colon cancer is in, Potter said pathologists currently look at lymph nodes present in the mesentery (the structure or membrane that allows blood vessels to flow into the abdominal region).If they don't show signs of cancer, the advantage of putting that patient on chemotherapy is small."In all probabilities they would be offset by the negative toxicity associated with being on chemotherapy.
"The problem is, the way it's done now, the pathologist who looks at the lymph nodes that are in the mesentery will select any that are large and then take some microscopic sections from them," he said."Only about one or two slides would be looked at from each lymph node.The patient could have a very small number of cancer cells in the lymph nodes that no one will be able to see -- "because there are literally billions of cells on the slides.
...
"If you have a patient who has very little risk of having cancer beyond the primary organ which is going to be removed, it doesn't make much sense to give that person aggressive chemotherapy or radiation therapy," said Dr. John F. Potter, director of the United States Military Cancer Institute at Walter Reed."These things have some toxicity in and of themselves."
To help determine what stage a patient's colon cancer is in, Potter said pathologists currently look at lymph nodes present in the mesentery (the structure or membrane that allows blood vessels to flow into the abdominal region).If they don't show signs of cancer, the advantage of putting that patient on chemotherapy is small."In all probabilities they would be offset by the negative toxicity associated with being on chemotherapy.
"The problem is, the way it's done now, the pathologist who looks at the lymph nodes that are in the mesentery will select any that are large and then take some microscopic sections from them," he said."Only about one or two slides would be looked at from each lymph node.The patient could have a very small number of cancer cells in the lymph nodes that no one will be able to see -- because there are literally billions of cells on the slides.