Brent Navran

"ArrayCGH scanning is a powerful example of how the arrayWoRxe Biochip Reader is enabling new microarray scanning applications-now being adopted by leading research, clinical and diagnostic laboratories," said Brent Navran, Life Sciences Product Line Manager for Applied Precision.

"In developing our partnership with MolecularWare, we searched for the best software package to provide functionality specifically requested by our customers," said Brent Navran, Applied Precision's product line manager for Biotechnology Solutions.
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Brent NavranProduct Line Manager, Biotechnology SolutionsTel: 425.557.1000Email: bnavran@api.com

Brent Navran, Product Line Manager - Life SciencesTel: 425.557.1000E-mail: bnavran@api.com

"Knowing the ever-increasing importance of temporal resolution to our customers, we have adapted Roper Scientific's impressive CoolSNAP HQTM Monochrome camera so that researchers conducting live-cell microscopy can have the best technology available," remarked Brent Navran, product line manager for biotechnology solutions at Applied Precision.
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"With the remarkable image quality that the CoolSNAP camera delivers, researchers can learn more from their live-cell image studies than ever before, and have confidence that the imaging from their DeltaVision is as accurate a depiction of cellular reality as is possible," explains Navran.

Brent Navran, product line manager for Applied Precision's biotechnology solutions, said, "By providing the highest quality images, experiment flexibility and repeatable information in an easy-to-use instrument, we can offer increased efficiency for scientists in both research and industrial applications today and in the future."

"Knowing the ever-increasing importance of temporal resolution to our customers, we have adapted Roper Scientific's impressive CoolSNAP HQ(TM) Monochrome camera so that researchers conducting live-cell microscopy can have the best technology available," remarked Brent Navran, product line manager for biotechnology solutions at Applied Precision.

Able to image at up to 20 frames per second, early users have observed that the CoolSNAP upgrade reduces exposure time from 175 milliseconds to 20-50 milliseconds.By reducing exposure time, Applied Precision's upgrade reduces cell-damaging photobleaching effects which have a substantial impact on overall temporal resolution in live-cell imaging.Reduced exposure time allows for observation of live cells for a longer period of time.Early users who could previously expect only 20 minutes of viewing time before a cell deteriorated can now regularly observe 60 minutes of quality viewing before the photobleaching effect takes over.

The CoolSNAP upgrade also offers DeltaVision customers a substantial increase in image intensity so that images are clearer and not overshadowed by background noise.
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"With the remarkable image quality that the CoolSNAP camera delivers, researchers can learn more from their live-cell image studies than ever before, and have confidence that the imaging from their DeltaVision is as accurate a depiction of cellular reality as is possible," explains Navran.

M.I.T. Biology Professor Peter Sorger's lab is an early pilot site for the CoolSNAP upgrade.Dr. Sorger's lab watches important chromosomes that very quickly oscillate back and forth during cell division.Being able to view the cell for a longer period of time increases the chances of accurately capturing the chromosomes at the extremes of their movement.

Applied Precision's CoolSNAP upgrade utilizes the value provided by Roper Scientific's CoolSNAP HQ Monochrome camera, which incorporates cooled CCD technology and low-noise electronics to achieve superior low-light sensitivity.The camera comes equipped with a Sony ICX285 progressive scan CCD chip with a 1392 X 1040 imaging pixel matrix.

Brent Navran, production line manager of the Life Sciences Group at Applied Precision, says the company is developing a submicrometer-resolution imager in preparation for future research needs to scan large microarrays with entire genomes on a single biochip."The vast majority of the market doesn't need it," Navran says.
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"It's a critical need," says Navran of Applied Precision, whose TRACKER microarray analysis software will output data in a format compliant to standards like MIAME.

"We recognize the significance of the research being conducted with our systems, and we're very excited to continue to improve the tools necessary for this critical work," said Brent Navran, Applied Precision's Life Sciences product line manager."It is very important to us that top researchers in the world rely on our products to speed their research while obtaining both high quality and quantifiable data."

About the DeltaVision Spectris System

The DeltaVision Spectris system provides real-time imaging capabilities to study dynamic processes within the cell, including, for example, protein transport within the nucleus.This real-time imaging feature, combined with the advanced point-visiting technique of the system, enables researchers to study multiple cells simultaneously.
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"With the remarkable image quality that the Spectris system delivers, researchers can discover more from their live-cell image studies than ever before, and have confidence that the results from their DeltaVision Spectris is as accurate a depiction of cellular reality as is possible," explains Navran.

About Applied Precision, LLC.

Applied Precision develops measurement, analysis and process control systems for Life Sciences, (particularly live-cell microscopy and genomics), the semiconductor industry, and precision motion control components.Applied Precision's specialized products are based on precisionware(TM), the company's unique convergence of mechanics, electronics, optics and software.Applied Precision, LLC. has been enabling advancements in the world's core technologies since its inception in 1985.Applied Precision (http://www.appliedprecision.com/) can be reached in the United States at 425-557-1000 or in the United Kingdom at +44-1672-518350.

"We recognize the significance of the research being conducted with our systems, and we're very excited to continue to improve the tools necessary for this critical work," said Brent Navran, Applied Precision's Life Sciences product line manager."It is very important to us that top researchers in the world rely on our products to speed their research while obtaining both high quality and quantifiable data."

About the DeltaVision Spectris System

The DeltaVision Spectris system provides real-time imaging capabilities to study dynamic processes within the cell, including, for example, protein transport within the nucleus.This real-time imaging feature, combined with the advanced point-visiting technique of the system, enables researchers to study multiple cells simultaneously.
...
"With the remarkable image quality that the Spectris system delivers, researchers can discover more from their live-cell image studies than ever before, and have confidence that the results from their DeltaVision Spectris is as accurate a depiction of cellular reality as is possible," explains Navran.

About Applied Precision, LLC.

Applied Precision develops measurement, analysis and process control systems for Life Sciences, (particularly live-cell microscopy and genomics), the semiconductor industry, and precision motion control components.Applied Precision's specialized products are based on precisionware(TM), the company's unique convergence of mechanics, electronics, optics and software.Applied Precision, LLC. has been enabling advancements in the world's core technologies since its inception in 1985.Applied Precision (http://www.appliedprecision.com) can be reached in the United States at 425-557-1000 or in the United Kingdom at +44-1672-518350.

"ArrayCGH scanning is a powerful example of how the arrayWoRxe Biochip Reader is enabling new microarray scanning applications -- now being adopted by leading research, clinical and diagnostic laboratories," said Brent Navran, Life Sciences Product Line Manager for Applied Precision.