Dr. Juanita L. Merchant

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  publish.aasld.org/conferences/meetings/Pages/ThirdAnnua - [Cached Version]
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  Juanita L. Merchant, MD, PhD University of Michigan School of Medicine

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  www.medicineatmichigan.org/magazine/2009/spring/limelig - [Cached Version]
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  Juanita Merchant
  
  Howard Markel (M.D. 1986), Ph.D., the George E. Wantz Distinguished Professor of the History of Medicine, director of the Center for the History of Medicine, and professor of pediatrics and communicable diseases and of psychiatry; and Juanita Merchant, M.D., Ph.D., professor of internal medicine and of molecular and integrative physiology, are among 65 new electees to the Institute of Medicine, a prestigious organization which is part of the National Academies and serves as a national resource for independent scientifically informed analyses and recommendations on health issues.
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  Merchant's research focuses on the molecular mechanisms underlying normal and cancerous epithelial cell growth in the luminal gastrointestinal tract.

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  Juanita Merchant, M.D., Ph.D.Associate Professor, Internal MedicineUniversity of Michigan

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  Juanita Merchant, M.D., Ph.D.Associate Professor, Internal MedicineUniversity of Michigan

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  www.gastro.org/wmspage.cfm?parm1=4342 - [Cached Version]
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  1998 Juanita L. Merchant, MD, PhD, Professor of Internal Medicine and Molecular and Integrative Physiology, University of Michigan

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  www.gastro.org/wmspage.cfm?parm1=3757 - [Cached Version]
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  "Till Death Do Us Part" , The Art of Mentoring - By Juanita L. Merchant, MD, PhD

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  Juanita L. Merchant, M.D., Ph.D.

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  www.eurekalert.org/pub_releases/2008-04/joci-jto041808. - [Cached Version]
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  The importance of these observations is discussed in detail in an accompanying commentary by Juanita Merchant, at the University of Michigan, Ann Arbor.
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  Juanita L. Merchant University of Michigan, Ann Arbor, Michigan, USA. Phone: (734) 647-2944; Fax: (734) 763-4686; E-mail: merchanj@umich.edu.
  
  View the PDF of this article at: https://www.the-jci.org/article.php?id=35344

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  www.spectrum.ieee.org/htmlCache/2002-01-16T192850Z_01_N - [Cached Version]
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  It turns out that H. pylori may be just one of many bacterial culprits, said Dr. Juanita Merchant of the University of Michigan, who led both studies.
  
  And drugs used to lower stomach acidity may actually promote the growth of these other bacteria, Merchant warned.
  
  "One important take-home point from our papers is that you don't want to block acid secretion over the long term just to treat either the bacterial overgrowth or the Helicobacter infection, because that's going to potentially create other problems," Merchant said.
  
  "Antibiotics should be used to treat such bacterial overgrowth, which will restore the normal acid-control mechanism."
  
  The strongest acid blockers are the most dangerous to use long-term, Merchant said.Her team tested omeprazole, sold by AstraZeneca under the brand names Prilosec and Losec.
  
  Another drug in the same class, known as proton pump inhibitors, is lansoprazole, sold under the name Prevacid by TAP pharmaceuticals, a joint venture of Abbott Laboratories Inc. and Japan's Takeda Chemical Industries Ltd. .
  
  "In treating patients with gastrointestinal disorders, physicians usually aim to increase the pH of the stomach (lower its acidity) ... to try to protect their stomach linings from ulceration -- which physicians initially believed was due only to stomach acid," Merchant said.
  
  "There is also the dogma that most ulcers are due to infections by Helicobacter."
  
  Merchant's team tested mice for their studies, published in the January issues of Gastroenterology and the American Journal of Physiology.
  
  ANTIBIOTICS GET RID OF INFLAMMATION
  
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  Merchant said it is probably the body's response to the bacteria that is causing the damage that leads to ulcers and stomach cancer.Her findings build on previous research by other scientists, who believe some people may be genetically programmed to respond more strongly to bacteria -- which is why only some people get ulcers from bacterial infections.
  
  "It's the inflammation that is probably doing the damage," Merchant said in a telephone interview.
  
  "It doesn't matter whether it is Helicobacter or bacterial overgrowth.The stomach reacts the same."
  
  The bacteria that could be involved include lactobacillus, enterobacter, staphylococcus and probionibacterium.
  
  What concerns Merchant is the possibility that strong acid blockers may become available over the counter, without a doctor's prescription.
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  "I don't think there is a problem over the short term," Merchant said."It is months and years of chronic acid suppression (that causes the problem)."
  
  In the long term, Merchant said, it may be best to treat gastritis with anti-inflammatory drugs -- perhaps something safer than the current available medications such as aspirin and ibuprofen, which can worsen stomach pain.But she stressed that many studies will have to be done in people before that could be determined.
  
  Copyright © 2001 Reuters Limited.All rights reserved.Republication or redistribution of Reuters Limited content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters Limited.Reuters Limited shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

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  www.physicianscientists.org/Meetings/Chicago2008/Mercha - [Cached Version]
  Published on: 3/11/2008    Last Visited: 3/21/2008  

  Dr. Juanita L. Merchant, MD, PhD
  
  Dr. Merchant is a Professor of Internal Medicine and Molecular and Integrative Physiology at the University of Michigan, Ann Arbor.She is also a faculty member in the Cellular and Molecular Biology Program.She received her B.S. degree with distinction in Biological Sciences from Stanford University and her M.D. and Ph.D. degrees from Yale University.She completed residency in Internal Medicine and a research fellowship in molecular Gastroenterology at the Massachusetts General Hospital in Boston and clinical fellowship in Gastroenterology at UCLA.
  
  Dr. Merchant is a member of the Editorial Boards for Journal of Clinical Investigation, Digestive Disease Sciences and Physiological Reviews.She serves on the national advisory boards for the Harold Amos (formerly Robert Wood Johnson) Minority Faculty Development Award, NIDDK Council and the advisory boards for three P30 Center Grants.Over the course of her education and throughout her faculty tenure, Dr. Merchant has received numerous prestigious awards and honors.She is a member of nine national professional associations, including the American Society for Clinical Investigation (ASCI), The Association of American Physicians (AAP), and the American Gastroenterological Association (AGA).As a part of her administrative responsibilities with the University of Michigan, she is a member of the Organogenesis and Cancer Centers and the executive committee of the University of Michigan Digestive Disease Center (P30) and the committee on Strategies and Tactics for Recruiting to Improve Diversity and Excellence (STRIDE).She has recently become an associate director of the Medical Scientist Training Program (MSTP).
  
  Dr. Merchant's primary research interests include transcriptional control mechanisms regulating cell growth and differentiation and microbial-host interactions in the upper GI tract.Dr. Merchant has co-authored numerous primary research publications, book chapters and abstracts in such journals as the Journal of Clinical Investigation, Proceedings of the National Academy of Sciences, Gastroenterology, Journal of Biological Chemistry, Molecular and Cellular Biology, American Journal of Physiology, Infection and Immunity.Several press releases have covered her work on the role of gastric infection in the development of peptic ulcer disease and gastric cancer.

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