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Published on: 4/5/2002
Last Visited: 4/5/2002
"TRAP is well-suited for post-genomic cancer drug discovery since it provides an efficient and rapid means of identifying active compounds across a wide diversity of targets," said Robert T. Lum, Ph.D., Vice President, Preclinical Development."It is also a means for accelerating the translation of basic cancer research results to clinical applications."
On Tuesday, April 9 from 1:00 p.m. to 5:00 p.m., Telik scientists will present "TLK286-Induced Activation of the Stress Response Apoptotic Signaling Pathway" (Abstract # 4772, poster session New Targets - New Agents 2).TLK286 is in Phase 2 testing in colorectal, ovarian, non-small cell lung and breast cancer.TLK 286 is activated by glutathione S-transferase (GST) P1-1, an enzyme which is over-expressed in many types of human cancers.Elevated GST P1-1 levels also are correlated with the development of resistance to many commonly used chemotherapeutic drugs.