Prof. Dennis Lo This is Me

Education

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1. 1. www.aacc.org

   www.aacc.org/AACC/about/awards - [Cached]

   Published on: 2/17/2008   Last Visited: 2/17/2008

   AACC > About AACC > Awards & Grants > Hall of Fame > Yuk-Ming Dennis Lo, MD
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   Yuk-Ming Dennis Lo, MD
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   Dr. Lo is professor of chemical pathology and the Dr. Li Ka Shing Professor of Medicine at The Chinese University of Hong Kong.He is also the associate dean for research of the faculty of medicine, the director of the Li Ka Shing Institute of Health Sciences, and associate director of the state laboratory in oncology in South China.Dr. Lo's main research interests lie in the biology and diagnostic applications of cell-free DNA and RNA in plasma.In 1997, Dr. Lo discovered the presence of cell-free fetal DNA in the plasma of pregnant women.The work that led to this award-winning paper originated from his demonstration that epigenetic markers can be used for the detection of fetal DNA in maternal plasma.Unlike genetic markers, in which no single marker can be informative in all pregnancies, epigenetic markers have the potential to be used as universal fetal DNA markers.In 2005, Dr. Lo developed the first such marker, SERPINB.In his award-winning paper, Dr. Lo demonstrated that the tumor suppressor gene RASSF1A exhibits a pattern of methylation which is reverse to that of SERPINB5, namely hypermethylated in the placenta but hypomethylated in maternal blood cells.This pattern of methylation allowed Dr. Lo to develop a simple methylation-sensitive restriction-enzyme-mediated real-time polymerase chain reaction assay for the detection of the hypomethylated RASSF1A gene.This RASSF1A assay could be implemented as a fetal DNA control for the performance of fetal RhD genotyping from maternal plasma.The concepts explored in this paper also have implications for the development of other fetal epigenetic markers for noninvasive prenatal diagnosis.Dr. Lo has pioneered a number of other important applications of plasma nucleic acids; he has published more than 230 articles in international journals.

2. 2. Sexual Health Issues - Maternal Blood Test Might Reveal Fetal Health

   www.sexualhealthissues.com/ms/ - [Cached]

   Published on: 9/17/2006   Last Visited: 9/17/2006

   Only about 3 percent of DNA in maternal blood plasma comes from the fetus, said study author Dennis Lo, a professor of chemical pathology at the Chinese University of Hong Kong.There are ways to differentiate the fetal DNA, such as looking for the male Y chromosome, he said, but that only works for male fetuses.
   
   In the new study, Lo and his colleagues report that they can differentiate maternal from fetal DNA by looking for a specific gene that acts differently in mothers and fetuses.
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   SOURCES: Siobhan Dolan, M.D., M.P.H., associate medical director, March of Dimes, White Plains, N.Y.; Dennis Lo, D.Phil, professor, chemical pathology, Chinese University of Hong Kong; Oct. 3-7, 2005, Proceedings of the National Academy Sciences online

3. 3. Clinical Chemistry -- Clinical Chemistry Editorial Board

   intl.clinchem.org/misc/edboard - [Cached]

   Published on: 9/11/2007   Last Visited: 9/11/2007

   Y. M. Dennis Lo The Chinese University of Hong Kong