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Published on: 3/14/2002
Last Visited: 11/24/2002
Robert Horvitz, PhD, awarded 2002 Nobel Prize for research on programmed cell deathHorvitz, member of ALSA's Cure ALS Advisory Committee
Today it was announced that H. Robert Horvitz, PhD, Massachusetts Institute of Technology, is one of three researchers to be awarded the 2002 Nobel Prize in Physiology and Medicine.The three Nobel Laureates, Sydney Brenner, John Suiston and Horvitz are being recognized for their discoveries (developing and using the round worm, c. elegans, as an experimental model) concerning "genetic regulation of organ development and programmed cell death."
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Horvitz has been involved in ALS research for many years using the round worm, C. elegans, as an experimental model.He is renowned for his work in human molecular genetics, with focus on the neurodegenerative disease amyotrophic lateral sclerosis.Horvitz is a past member and chair of The ALS Association's Scientific Review Committee.Currently, he is a member of ALSA's Cure ALS Advisory Committee that guides the Lou Gehrig Challenge: Cure ALS research initiative.
He was a member of the team that included Bob Brown, Teepu Siddique and David Patterson, et al, who linked familial ALS to the mutant SOD1 gene in the early 1990s.In an overview about Horvitz on the MIT web site, he states: "In collaboration with others, we showed that one gene responsible for the inherited form of amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease) encodes the enzyme Cu/Zn superoxide dismutase (SOD), which catalyzes the conversion of the free radical superoxide to hydrogen peroxide.We are now seeking other genes responsible for ALS and studying C. elegans models of ALS and of other human genetic neurologic and/or aging disorders…"
He has organized and led ALSA Scientific Workshops including one on "Superoxide Dismutase and Motor Neuron Disease", held in 1998 at Banbury Center, Cold Spring Harbor Laboratory, and participated in other ALSA funded workshops focusing on cellular biology of the motor neuron, free radicals and programmed cell death.
The ALS Association is indeed proud to have Robert Horvitz bring his expertise to bear on ALS as a member of the Cure ALS Advisory Committee and his continued research on ALS.Having a person of Dr. Horvitz's stature, a Nobel Laureate, as a longtime participant and leader in ALSA's research program exemplifies the level of excellence ALSA seeks in its efforts to find a cure for ALS.
For more information about the 2002 Nobel Prize, Robert Horvitz and his work go to www.nobel.se/medicine/laureates/2002/press.html
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