Dr. Jeff Harper

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  www.agbioworld.org/PHP/index_search.php?alpha=H - [Cached Version]
  Published on: 6/10/2006    Last Visited: 6/10/2006  

  Jeff HarperAssociate ProfessorThe Scripps Research Institute

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  intl.plantphysiol.org/misc/edboard.shtml - [Cached Version]
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  Jeff HarperUniversity of Nevada, Reno

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  2004 Plant Molecular Genetics - [Cached Version]
  Published on: 3/15/2004    Last Visited: 6/29/2004  

  Jeff Harper, The Scripps Research Institute

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  AGENCIES FORM JOINT PROGRAM IN PLANT BIOLOGY (94-213) - [Cached Version]
  Published on: 12/14/1994    Last Visited: 5/31/2008  

  Jeffrey Harper, Scripps Research Institute, La Jolla, CA

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  AgBioWorld - Agricultural biotechnology can help... - [Cached Version]
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  Jeff Harper Associate Professor The Scripps Research Institute

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  American Society for Gravitational and Space Biology... - [Cached Version]
  Published on: 1/2/2001    Last Visited: 5/10/2001  

  The Principal Investigators in the NASA/NSF Network are : Sarah M. Assmann , Pennsylvania State University ; Ronald W. Davis , Stanford University ; Allison DeLong , Brown University ; Michael Evans , Ohio State University ; Jeff Harper , Scripps Research Institute ; Hideo Ishikawa , Ohio State University ; Joe Kieber , University of Illinois at Chicago ; Barbara Pickard , Washington University in St. Louis ; Dieter Soll , Yale University ; Edgar Spalding , University of Wisconsin ; and Fedora Sutton , South Dakota State University.

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  DanforthCenter.org - [Cached Version]
  Published on: 8/9/2001    Last Visited: 5/8/2002  

  Dr. Jeff Harper
  
  The Scripps Research Institute

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  Gordon Research Conferences - 2008 Program (Plant... - [Cached Version]
  Published on: 7/16/2008    Last Visited: 9/16/2008  

  Jeff Harper (University of Nevada)

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  LEHLE SEEDS Welcome & Home Page - [Cached Version]
  Published on: 1/4/2003    Last Visited: 10/4/2003  

  Jeffrey Harper (Scripps Research Institute) presented results from a study on ACA9, a calmodulin-activated calcium pump involved in pollen tube growth.Harper and co-workers have focused on the biological roles of calcium efflux by autoinhibited calcium ATPases (ACAs).
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  Harper and co-workers showed that pollen from aca9 mutants has reduced growth potential, and they suggest that pollen tip growth defects may arise in the mutant when the usual Ca2+ gradient is affected.Harper concluded with a brief description of an aca4/aca11 knockout mutant that forms lesions and is thought to be affected in the regulation of Ca2+ -triggered apoptosis.

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  PLANT PHYSIOLOGY ONLINE -- Cosgrove et al. 124 (2): 499 - [Cached Version]
  Published on: 10/1/2000    Last Visited: 3/11/2001  

  Jeffrey Harper ( Scripps Research Institute , La Jolla , CA ) described recent insights into how these changes are generated , how information is encoded in the spatial and temporal dynamics of the Ca2+ signal , and how this information is decoded by cellular response elements.
  
  The phenotype of transgenic tobacco lines overexpressing CAX1 , an Arabidopsis Ca2+/H+ antiporter , resemble Ca2+-starved plants , despite the fact that total Ca2+ in the plant was high.The physiological defects in these transgenic lines can be corrected by Ca2+ supplementation.These results indicate that the endogenous function of CAX1 is in maintaining low cytoplasmic Ca2+ and reinforce the view that the correct , coordinated regulation of organelle Ca2+ transporter activities is essential in supporting plant cell function.Harper's investigations of the control of the Arabidopsis endoplasmic reticulum Ca2+ pump ACA2 further suggested that such transporters show complex feedback regulation through Ca2+-dependent regulators such as calmodulin and Ca2+-dependent protein kinases.
  
  Harper also described use of a GFP-based Ca2+ sensor , named Cameleon , in plants.When Ca2+ binds to the calmodulin domain of the Cameleon protein it induces a conformational change which can be detected by altered fluorescence resonance energy transfer between its component cyan and yellow fluorescent protein domains.By monitoring the efficiency of fluorescence resonance energy transfer , Ca2+ levels can be measured.The Cameleon protein can be tailored in its Ca2+ sensitivity , targeted to specific cell types or organelles , and even fused to signal transduction or Ca2+-regulatory elements ( e.g. ACA2 ) to report Ca2+ levels in the microenvironment of a particular signaling system.This new technology presents exciting opportunities for following Ca2+ dynamics in plants.
  
  The symposium was unusual in its attempt to bring molecular biologists and ecologists into dialogue around the theme of plant signaling mechanisms.

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