Dr. Claudio Fiocchi

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  www.advancesinibd.com/2007/faculty.html - [Cached Version]
  Published on: 1/1/2007    Last Visited: 4/18/2008  

  Claudio Fiocchi, MDCase Western Reserve University

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  Giving Colitis the Big Chill - [Cached Version]
  Published on: 10/24/2001    Last Visited: 10/24/2001  

  Dr. Claudio Fiocchi , professor of medicine at Case Western Reserve University School of Medicine , in Cleveland , and a spokesman for the Crohn's and Colitis Foundation of America , says ICE inhibitors may prove useful against colitis , but it's too soon to say for sure.While mouse models of the disease are an important proving ground for any therapy , they're not perfect matches for the human form of the condition , he says.
  
  Fiocchi says immune responses for short and prolonged inflammation aren't identical in humans.It's an acute inflammation rather than an immunologic inflammation , so it is different..Even chronic colitis in mice is really just an extended , acute inflammatory response , he says.
  
  On the other hand , Fiocchi says if ICE blockers work in additional models of colitis , then it would be even more convincing..
  
  What To Do
  
  Recently , scientists reported that colitis patients taking infliximab , marketed as Remicade , are at increased risk of tuberculosis and should be tested for the disease.For more on that link , check the Crohn's and Colitis Foundation of America.
  
  For more about colitis and related conditions , check the National Association for Colitis and Crohn's or the National Institute of Diabetes and Digestive and Kidney Diseases.

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  Inflammatory Bowel Disease Monitor, a CME-accredited... - [Cached Version]
  Published on: 5/31/2008    Last Visited: 5/16/2009  

  Claudio Fiocchi Case Western Reserve University, Cleveland, OH, USA

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  Info Gastro 1999 Registration Issue - Investigation of... - [Cached Version]
  Published on: 1/1/1999    Last Visited: 8/23/2006  

  Investigation of cytokines involved in inflammatory processes leading to digestive diseases is the goal of research now being conducted by Dr. Claudio Fiocchi, professor of medicine and head of gastroenterology research, Case Western Reserve University, Cleveland, Ohio.
  
  In his state-of-the-art lecture, Dr. Fiocchi will discuss how cytokines alter the behavior of cells, producing either a greater-than-normal inflammatory response or enhancing intrinsic anti-inflammatory responses as well."Cytokines are key mediators of inflammation in general, and this is also true for inflammation in the gastrointestinal tract in diseases such as Crohn's disease, ulcerative colitis and celiac disease," said Dr. Fiocchi in an earlier interview.
  
  Understanding the type, amount and timing of the cytokines being released is important, he added, initially because it will help determine the pathophysiology of certain inflammatory responses in the gut.
  
  Later on, a better understanding of how inflammation develops opens up potential avenues through which pathological responses may be controlled through either modulation, inhibition or augmentation of specific cytokine production.By blocking certain cytokines, for example, processes which would normally augment the inflammatory response could be down-regulated and inflammation subsequently repressed.
  
  Conversely, manipulation of cytokines which mediate anti-inflammatory responses could help suppress inflammation and symptoms of diseases, such as ulcerative colitis and Crohn's disease, in which inflammation plays a fundamental pathogenic role.Research in this area is already paying off, as Dr. Fiocchi noted.
  
  For example, anti-tumor necrosis factor antibodies are currently being used to treat Crohn's disease to block events which promote inflammation.Treatment with interleukin-10 and interleukin-11, on the other hand, supplies anti-inflammatory cytokines which in turn dampen down inflammation.
  
  "Cytokines have multiple actions but one of the hopes is that we can find a way of modulating the predominant function of specific cytokines so that we can treat inflammation by attacking a more specific therapeutic target," said Dr. Fiocchi.Dr. Fiocchi will give his state-of-the-art lecture on Tuesday, August 31st at 8:00 to 8:45 am in meeting rooms 10, 11 & 12 of the Convention Centre.

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  Menu - [Cached Version]
  Published on: 4/12/1999    Last Visited: 7/12/2003  

  Claudio Fiocchi, M.D.Professor of Medicine, Director of Gastroenterology Research Case Western Reserve University School of Medicine

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  Nutrition & Diet - [Cached Version]
  Published on: 11/1/2001    Last Visited: 5/30/2007  

  Below, Professor of Medicine Dr. Claudio Fiocchi, of Case Western Reserve University in Cleveland, Ohio, talks about these beneficial bacteria, and what role they might one day play in the prevention and treatment of gastrointestinal disorders.

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  Research Institute of the University Hospitals of... - [Cached Version]
  Published on: 7/26/2002    Last Visited: 10/21/2003  

  Claudio Fiocchi, M.D.
  
  Professor Medicine - Gastroenterology

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  Researchers Identify 170 Genes Involved in Crohn's... - [Cached Version]
  Published on: 3/8/2001    Last Visited: 4/27/2002  

  Other authors of the study are Ian Lawrance and Claudio Fiocchi from Case Western Reserve University School of Medicine.

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  Reviews 2 - [Cached Version]
  Published on: 4/10/2004    Last Visited: 9/11/2005  

  Claudio Fiocchi, Professor of Medicine, Case Western Reserve University, Cleveland, U.S.A.

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  TodayMD (Crohns-disease) Probiotics: Are Bugs a Man's... - [Cached Version]
  Published on: 5/15/2003    Last Visited: 10/20/2008  

  Below, Professor of Medicine Dr. Claudio Fiocchi, of Case Western Reserve University in Cleveland, Ohio, talks about these beneficial bacteria, and what role they might one day play in the prevention and treatment of gastrointestinal disorders.

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