Dr. Dean W. Felsher This is Me

Education

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1. 1. www.healthtech.com

   www.healthtech.com/bmks/bmk/ov - [Cached]

   Published on: 7/3/2008   Last Visited: 7/3/2008

   Dean W. Felsher, M.D., Ph.D., Associate Professor, Division of Oncology, Stanford UniversityWe have developed a novel nanoscale proteomic method for the analysis of oncorpotein expression and phospyorylation in clinical specimens.

2. 2. Gordon Research Conferences - 2008 Program (Cancer Models & Mechanisms)

   www.grc.org/programs.aspx?year - [Cached]

   Published on: 6/30/2008   Last Visited: 7/1/2008

   Dean Felsher (Stanford)
   ...
   Discussion Leader: Dean Felsher (Stanford)

3. 3. carsontahoe.staywellsolutionsonline.com

   carsontahoe.staywellsolutionso - [Cached]

   Published on: 7/1/2008   Last Visited: 7/6/2008

   But the research does clear a pathway for scientists to follow as they determine which "switches" they need to turn off to stop cancer in its tracks, said study senior author Dr. Dean Felsher, an associate professor of medicine and oncology at Stanford University School of Medicine.
   
   "You do not have to completely shut off a cancer switch to have a beneficial effect on cancer," he said."It's a useful improvement over how we've been understanding things."
   
   Normally, cells are programmed to commit suicide if they detect that they're damaged."The cell says, 'I shouldn't be alive, something is wrong with me, I'm broken.' And it decides to kill itself," Felsher said.
   ...
   But its "Jekyll and Hyde" nature can turn it into a villain that sends marching orders to cells, Felsher said.
   
   In the new research, Felsher and colleagues worked with genetically engineered mice to develop a way to slightly adjust the Myc switch instead of turning it on or off.
   
   The study was published in the July 1 issue of Cancer Research.
   
   The researchers found that by turning down the Myc switch, like using a dimmer switch on a lamp, they could shrink tumor cells to normal sizes and restore their ability to die as they're supposed to.
   
   The findings suggest that researchers trying to turn off the signal may not need to go that far, Felsher said."Before, we thought there were these switches that you had to turn on and off," he said.
   ...
   SOURCES: Dean Felsher, M.D., Ph.D., associate professor, medicine and oncology, Stanford University School of Medicine, Palo Alto, Calif.; William Tansey, Ph.D., professor, Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.; July 1, 2008, Cancer Research