Dr. Pascal M. Dohmen

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  10TH CONGRESS - PROGRAMME [2005] - [Cached Version]
  Published on: 11/30/2006    Last Visited: 6/15/2008  

  P.M. Dohmen, Charite Hospital, Berlin

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  AAMC: Neighbors News - [Cached Version]
  Published on: 3/21/2003    Last Visited: 12/24/2003  

  "Using this tissue-engineered valve overcomes many of the problems with mechanical or donor valves because it is a living structure from the patient's own tissue, and so it does not cause an immunological reaction," says Dr. Pascal M. Dohmen, head of tissue engineering research and staff surgeon of the department of cardiovascular surgery at Charité Hospital in Berlin, Germany.
  
  Dr. Dohmen and colleagues presented data on the first 23 patients to receive tissue-engineered pulmonary valves in the heart, a procedure still considered experimental.
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  Dr. Dohmen engineered a new pulmonary valve from the patients' own cells.

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  Advanced Heart Care, P.A. - [Cached Version]
  Published on: 2/7/2003    Last Visited: 11/17/2003  

  Mechanical, pig and cattle valves work well for patients older than 60, but may not be appropriate for younger patients since they wear out too soon, said Dr. Pascal Dohmen, head of tissue engineering research at Charite Hospital in Berlin.
  
  Valves taken from human cadavers can present other health hazards by provoking an immune reaction to another person's tissue.
  
  To eliminate that risk, Dohmen and colleagues made valves using a patient's own cells.
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  Dohmen said the patient's own cells form a completely new scaffold after about a year.
  
  His patients have been studied for up to three years since receiving the tissue-engineered valves."The patients are in very good shape," he said.
  
  Imaging tests of the patients' hearts showed the valves were functioning normally and showed no signs of the calcium build-up that can destroy other types of valves, he said.
  
  Patients also had a shorter recovery than usual for valve-replacement surgery, and had no postoperative fever, a common phenomenon with other valves, Dohmen said.

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  Baptist Online Newsletter Article - [Cached Version]
  Published on: 1/1/2004    Last Visited: 1/28/2004  

  "Using this tissue-engineered valve overcomes many of the problems with mechanical or donor valves because it is a living structure from the patient's own tissue, and so it does not cause an immunological reaction," says Dr. Pascal M. Dohmen, head of tissue engineering research and staff surgeon of the department of cardiovascular surgery at Charité Hospital in Berlin, Germany.
  
  Dr. Dohmen and colleagues presented data on the first 23 patients to receive tissue- engineered pulmonary valves in the heart, a procedure still considered experimental.
  ...
  Dr. Dohmen engineered a new pulmonary valve from the patients' own cells.

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  Greenville Hospital System - [Cached Version]
  Published on: 1/1/2004    Last Visited: 1/21/2005  

  ,Using this tissue-engineered valve overcomes many of the problems with mechanical or donor valves because it is a living structure from the patient,s own tissue, and so it does not cause an immunological reaction,, says Dr. Pascal M. Dohmen, head of tissue engineering research and staff surgeon of the department of cardiovascular surgery at Charit, Hospital in Berlin, Germany.
  
  Dr. Dohmen and colleagues presented data on the first 23 patients to receive tissue-engineered pulmonary valves in the heart, a procedure still considered experimental.
  ...
  Dr. Dohmen engineered a new pulmonary valve from the patients, own cells.

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  Heart - [Cached Version]
  Published on: 7/2/2003    Last Visited: 2/27/2004  

  "Using this tissue-engineered valve overcomes many of the problems with mechanical or donor valves because it is a living structure from the patient's own tissue, and so it does not cause an immunological reaction," researcher Dr. Pascal M. Dohmen, head of tissue engineering research at Charit Hospital in Berlin, says in a prepared statement.

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  Heart Care - Heart Care - January 2004 - [Cached Version]
  Published on: 1/1/2004    Last Visited: 3/28/2009  

  "Using this tissue-engineered valve overcomes many of the problems with mechanical or donor valves because it is a living structure from the patient's own tissue, and so it does not cause an immunological reaction," says Dr. Pascal M. Dohmen, head of tissue engineering research and staff surgeon of the department of cardiovascular surgery at Charité Hospital in Berlin, Germany.
  
  Dr. Dohmen and colleagues presented data on the first 23 patients to receive tissue-engineered pulmonary valves in the heart, a procedure still considered experimental.
  ...
  Dr. Dohmen engineered a new pulmonary valve from the patients' own cells. The surgical team implanted the patients' healthy pulmonary valve into the aortic position.

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  Heart Center - [Cached Version]
  Published on: 11/24/2003    Last Visited: 8/1/2006  

  "Using this tissue-engineered valve overcomes many of the problems with mechanical or donor valves because it is a living structure from the patient's own tissue, and so it does not cause an immunological reaction," says Dr. Pascal M. Dohmen, head of tissue engineering research and staff surgeon of the department of cardiovascular surgery at Charit, Hospital in Berlin, Germany.
  
  Dr. Dohmen and colleagues presented data on the first 23 patients to receive tissue-engineered pulmonary valves in the heart, a procedure still considered experimental.
  ...
  Dr. Dohmen engineered a new pulmonary valve from the patients' own cells.

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  SouthBendTribune.com: Heart patients may soon produce... - [Cached Version]
  Published on: 11/19/2003    Last Visited: 11/20/2003  

  "We've had very good results," said Pascal Dohmen, head of tissue engineering research and a surgeon at Charite Hospital in Berlin.

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  Tissue Engineered - [Cached Version]
  Published on: 11/12/2003    Last Visited: 5/22/2009  

  "Using this tissue-engineered valve overcomes many of the problems with mechanical or donor valves because it is a living structure from the patient's own tissue, and so it does not cause an immunological reaction," said Pascal M. Dohmen, M.D., head of tissue engineering research and staff surgeon of the department of cardiovascular surgery at Charité Hospital in Berlin, Germany.
  
  Dohmen and colleagues presented data on the first 23 patients to receive tissue-engineered pulmonary valves in the heart.
  ...
  Dohmen and colleagues engineered a new pulmonary valve from the patients' own cells. They implanted the patients' healthy pulmonary valve into the aortic position. Then they implanted the tissue-engineered valve in the right ventricular outflow tract, where the pulmonary valve originally was.
  
  With up to three years of follow-up, the engineered valve's performance was "excellent," Dohmen reported. Echocardiography showed that the valves were functioning normally; the valve leaflets or flaps appeared smooth and pliable and showed no signs of calcification.
  
  The patients were discharged from the hospital earlier, and were in better condition than other patients. They had no post-operative fever, which is often found in patients receiving donor heart valves, Dohmen said.
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  "In animal studies, we have seen that this matrix or scaffold will be absorbed by the body," Dohmen said.
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  Dohmen limits the use of the tissue-engineered valves to adults up to 60 years of age, but plans to explore the growth potential of the valves, with the hope of using them in children with congenital heart disease.
  
  The heart valve scaffold technique is still considered experimental, he said.

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