Dr. Guy Debonnel

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  www.pressreleasegold.com/08/23/18.htm - [Cached Version]
  Published on: 8/22/2006    Last Visited: 5/14/2007  

  "Depression is a devastating illness, which affects around 10% of people at some point in their life," says Dr. Guy Debonnel an MUHC psychiatrist, professor in the Department of Psychiatry at McGill University, and principal author of the new research.
  ...
  "These 'knock-out' mice were then tested using separate behavioral, electrophysiological and biochemical measures known to gauge 'depression' in animals," says Dr. Debonnel."The results really surprised us; our 'knock-out' mice acted as if they had been treated with antidepressants for at least three weeks."
  
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  This research represents the first time depression has been eliminated through genetic alteration of an organism."The discovery of a link between TREK-1 and depression could ultimately lead to the development of a new generation of antidepressant drugs," noted Dr. Debonnel.

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  Dr. Guy Debonnel an MUHC psychiatrist, professor in the Department of Psychiatry at McGill University, and principal author of the new research.
  ...
  "These 'knock-out' mice were then tested using separate behavioral, electrophysiological and biochemical measures known to gauge 'depression' in animals," says Dr. Debonnel."The results really surprised us; our 'knock-out' mice acted as if they had been treated with antidepressants for at least three weeks."
  
  This research represents the first time depression has been eliminated through genetic alteration of an organism. "The discovery of a link between TREK-1 and depression could ultimately lead to the development of a new generation of antidepressant drugs," noted Dr. Debonnel.

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  forum.nightssanctuary.com/ar/t109.htm - [Cached Version]
  Published on: 12/28/2006    Last Visited: 4/17/2007  

  The research represents the first time that depression has been eliminated genetically in any organism, said Guy Debonnel, a psychiatrist and professor at McGill University.
  
  Debonnel and his colleagues achieved this effect by creating and breeding mice lacking a gene also found in humans that affects the transmission of the mood-modulating chemical serotinin.
  
  Mice without the gene, called TREK-1, acted as if they had been treated with anti-depressants for at least three weeks, he said.

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  Published on: 5/25/2007    Last Visited: 5/25/2007  

  The experiments, over two years in Montreal and Nice, France, showed that in stressful situations the genetically modified mice do not exhibit symptoms of depression, explained McGill University Health Centre psychiatrist Guy Debonnel.
  
  The mice were bred without the Trek-1 gene, which affects transmission of serotonin in the brain.In various behavioural situations in the lab, these mice are found to be "non-depressive."
  
  "When you put them in a bucket of water and they have no escape and can only swim or float, after a while normal mice will show signs of depression," said Debonnel, who is senior author of the research.
  
  Normal mice "will just let go and not fight," but the genetically modified mice will continue swimming and never stop.
  
  "To get the same kind of behaviour from a normal mouse you would have to treat it for three weeks with antidepressants," he said.
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  "We found that in these mice the electrical activity is two or three times higher than in normal mice," said Debonnel, adding this strengthened the conclusion that the absence of this gene is "like removing a brake on the serotonin system."
  
  Almost all antidepressants on the market today the family known as SSRIs (selective serotonin reuptake inhibitors) work by regulating the flow of serotonin.But these antidepressants do not work for about one-third of clinically depressed patients which is where this research offers some hope.
  
  The research, published this week in Nature Neuroscience, indicates that a drug that blocks the Trek-1 gene and receptor in humans could be used to design an effective antidepressant, Debonnel noted.
  
  "Industry is certainly working on Trek-1 receptors, but up to now there was no indication that these compounds might be interesting in treating depression," Debonnel said.
  
  There is "a high level of homology" between the receptors of these rodents and those of humans, Debonnel said.

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  TheTyee.ca, Canada - Oct 26, 2006... class," says McGill psychiatrist Dr. Guy Debonnel about the test-stimulation of his first DBS patient through the multi-centre DBS for depression trial. ...

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  'Happy mice' may harbour cure for depression - [Cached Version]
  Published on: 8/23/2006    Last Visited: 8/23/2006  

  Current medications for clinical depression are ineffective for a third of patients, which is why the development of alternate treatments is so important," says Dr. Guy Debonnel an MUHC psychiatrist, professor in the Department of Psychiatry at McGill University, and principal author of the new research.
  
  "These 'knock-out' mice were then tested using separate behavioral, electrophysiological and biochemical measures known to gauge 'depression' in animals.The results really surprised us; our 'knock-out' mice acted as if they had been treated with antidepressants for at least three weeks," says Debonnel.
  
  "The discovery of a link between TREK-1 and depression could ultimately lead to the development of a new generation of antidepressant drugs," noted Dr. Debonnel.

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  CNW Group - [Cached Version]
  Published on: 8/22/2006    Last Visited: 8/22/2006  

  "Depression is a devastating illness, which affects around 10% of people at some point in their life," says Dr. Guy Debonnel an MUHC psychiatrist, professor in the Department of Psychiatry at McGill University, and principal author of the new research.
  ...
  "These 'knock-out' mice were then tested using separate behavioral, electrophysiological and biochemical measures known to gauge 'depression' in animals," says Dr. Debonnel.

• 
  Ever-Happy Mice May Hold Key to New Treatment of... - [Cached Version]
  Published on: 1/1/2006    Last Visited: 11/21/2006  

  "Depression is a devastating illness, which affects around 10% of people at some point in their life," says Dr. Guy Debonnel an MUHC psychiatrist, professor in the Department of Psychiatry at McGill University, and principal author of the new research.
  ...
  "These 'knock-out' mice were then tested using separate behavioral, electrophysiological and biochemical measures known to gauge 'depression' in animals," says Dr. Debonnel.
  ...
  "The discovery of a link between TREK-1 and depression could ultimately lead to the development of a new generation of antidepressant drugs," noted Dr. Debonnel.

• 
  Ever-happy mice may hold key to new treatment of... - [Cached Version]
  Published on: 1/1/2006    Last Visited: 8/25/2006  

  "Depression is a devastating illness, which affects around 10% of people at some point in their life," says Dr. Guy Debonnel an MUHC psychiatrist, professor in the Department of Psychiatry at McGill University, and principal author of the new research.
  ...
  "These 'knock-out' mice were then tested using separate behavioral, electrophysiological and biochemical measures known to gauge 'depression' in animals," says Dr. Debonnel."The results really surprised us; our 'knock-out' mice acted as if they had been treated with antidepressants for at least three weeks."
  
  This research represents the first time depression has been eliminated through genetic alteration of an organism."The discovery of a link between TREK-1 and depression could ultimately lead to the development of a new generation of antidepressant drugs," noted Dr. Debonnel.

• 
  Ever-happy mice may hold key to new treatment of... - [Cached Version]
  Published on: 8/22/2006    Last Visited: 3/20/2008  

  "Depression is a devastating illness, which affects around 10% of people at some point in their life," says Dr. Guy Debonnel an MUHC psychiatrist, professor in the Department of Psychiatry at McGill University, and principal author of the new research.
  ...
  "These 'knock-out' mice were then tested using separate behavioral, electrophysiological and biochemical measures known to gauge 'depression' in animals," says Dr. Debonnel."The results really surprised us; our 'knock-out' mice acted as if they had been treated with antidepressants for at least three weeks."
  
  This research represents the first time depression has been eliminated through genetic alteration of an organism."The discovery of a link between TREK-1 and depression could ultimately lead to the development of a new generation of antidepressant drugs," noted Dr. Debonnel.

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