Prof. Charles M. Deber

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  biochemistry.utoronto.ca/graduate_studies/recent_gradua - [Cached Version]
  Published on: 11/19/2007    Last Visited: 1/21/2008  

  Supervisor: Charles Deber
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  Supervisor: Charles Deber

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  www.americanpeptidesociety.org/memoriam/blout.asp - [Cached Version]
  Published on: 10/12/2008    Last Visited: 3/30/2008  

  A special issue of Biopolymers dedicated to his memory is being prepared, with guest editors Barbara Brodsky, Charles Deber, and myself.

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  19th American Peptide Symposium - [Cached Version]
  Published on: 6/20/2004    Last Visited: 6/17/2006  

  Charles Deber received his BSc at Brooklyn Poly with Murray Goodman, his PhD at MIT under Arthur C. Cope, and was a post-doctoral fellow with Elkan Blout at Harvard Medical School.
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  Dr. Deber's career-long research approach has involved the application of peptide chemistry to biochemical phenomena, to deduce experimentally how sequence confers protein structure and function.In recent years, he has applied this approach to study of the amino acid 'motifs' which determine helix-helix interactions between segments in the membrane domains of proteins with the goal of deciphering the molecular basis for misfolding defects that often lead to disease states.Dr. Deber received the Vincent duVigneaud Award of the American Peptide Society in 2000, and the following year, he was elected a Fellow of the Royal Society of Canada, giving him membership in the Canadian Academy of Sciences.

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  Awards - [Cached Version]
  Published on: 3/16/2003    Last Visited: 6/30/2004  

  Charles M. Deber University of Toronto

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  BiofilmsONLINE.com : News : Researchers Uncover a... - [Cached Version]
  Published on: 6/26/2001    Last Visited: 7/9/2008  

  "We now have a clearer picture of why the protein doesn't function properly in the milder form of cystic fibrosis - segments of the protein are sticking together, interfering with the flow of chloride in and out of the cell," said Dr. Charles Deber, the study's principal investigator, a senior scientist in the HSC Research Institute and a professor of Biochemistry at the University of Toronto.Cystic fibrosis is not just one distinct phenotype, as researchers have found hundreds of different mutations in the CF gene and the corresponding protein.The milder form of cystic fibrosis, also known as pancreatic sufficient CF, occurs in 10-15 per cent of CF patients.In this form of the disease, which often manifests as lung disease and male infertility, CFTR is able to carry out partial function.In the more severe forms of cystic fibrosis, the protein never assembles properly and no chloride can be transported."This opens the door for new avenues of research in terms of rational drug design," added Dr. Deber."We will look for molecules that could possibly break up the abnormal bond that is causing the protein strands to stick together." CFTR is a membrane protein with a massive and complicated structure.Membrane proteins, which regulate the stable internal physiological conditions of the cell in a controlled way, allowing for such things as intracellular communication, are very difficult to study. "We had to develop and refine molecular biological techniques in order to accurately study this membrane protein.This research will add to the body of knowledge about membrane proteins, which are also implicated in other diseases such as cancer, diabetes, and hypertension," said Dr. Alex Therien, the study's lead author and a Canadian Institutes of Health Research (CIHR) postdoctoral fellow in Dr. Deber's lab.
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  The other author on this paper is Fiona Grant, who was student in Dr. Deber's lab as part of the Samuel Lunenfeld Research Summer Student Program in the HSC Research Institute.

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  Capture the opportunity: Bio21 - [Cached Version]
  Published on: 12/5/2004    Last Visited: 2/6/2006  

  Seminar by Professor Charles Deber, Professor of Biochemistry, University of Toronto and Senior Scientist, Structural Biology & Biochemistry, Hospital for Sick Children, Toronto, Canada

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  Department of Chemistry: Seminar - [Cached Version]
  Published on: 3/10/2005    Last Visited: 8/30/2006  

  Charles DeberUniversity of Toronto

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  Gordon Research Conferences - 2007 Program... - [Cached Version]
  Published on: 7/18/2007    Last Visited: 9/12/2007  

  Charles M. Deber (University of Toronto, Ontario, Canada)

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  Gordon Research Conferences - 2008 Program (Peptides,... - [Cached Version]
  Published on: 2/19/2008    Last Visited: 9/16/2008  

  Charles M. Deber (University of Toronto)"Design of Peptide Models of Membrane Protein Folding"
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  Discussion Leader: Charles M. Deber (Hospital for Sick Children / University of Toronto)

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  HSC: News Releases - [Cached Version]
  Published on: 6/26/2001    Last Visited: 12/4/2006  

  "We now have a clearer picture of why the protein doesn't function properly in the milder form of cystic fibrosis - segments of the protein are sticking together, interfering with the flow of chloride in and out of the cell," said Dr. Charles Deber, the study's principal investigator, a senior scientist in the HSC Research Institute and a professor of Biochemistry at the University of Toronto.
  
  Cystic fibrosis is not just one distinct phenotype, as researchers have found hundreds of different mutations in the CF gene and the corresponding protein.The milder form of cystic fibrosis, also known as pancreatic sufficient CF, occurs in 10-15 per cent of CF patients.In this form of the disease, which often manifests as lung disease and male infertility, CFTR is able to carry out partial function.In the more severe forms of cystic fibrosis, the protein never assembles properly and no chloride can be transported.
  
  "This opens the door for new avenues of research in terms of rational drug design," added Dr. Deber.
  ...
  This research will add to the body of knowledge about membrane proteins, which are also implicated in other diseases such as cancer, diabetes, and hypertension," said Dr. Alex Therien, the study's lead author and a Canadian Institutes of Health Research (CIHR) postdoctoral fellow in Dr. Deber's lab.
  ...
  The third author on this paper is Fiona Grant, who was student in Dr. Deber's lab as part of the Samuel Lunenfeld Research Summer Student Program in the HSC Research Institute.

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