Dr. Stephen J. DeArmond

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  www.agec.org/programs/conferences/BP_Alzheimers/schedul - [Cached Version]
  Published on: 10/7/2008    Last Visited: 2/29/2008  

  Stephen DeArmond, MD, PhD

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  www.mad-cow.org/UKCJD/CJD_news48.html - [Cached Version]
  Published on: 10/7/2008    Last Visited: 12/11/2007  

  Stephen DeArmond of the University of California in San Francisco said that inflamed tonsils might have given the agent responsible for BSE and vCJD a chance to gain entry to the body.The idea could explain why relatively few had the disease and why young people, who suffer more tonsillitis, seemed at particular risk.
  
  He told the BBC that there was no experimental evidence backing the idea, but that it was possible."All I am trying to do is search for something that would get the protein into the lymphoreticular system, particularly into the tonsils, and certainly some irritation there, injury or inflammation, might have been one way."
  
  The tonsils are known to be a reservoir for the prion proteins which cause vCJD."Why does vCJD get into the tonsils, for instance, and it doesn't happen in sporadic CJD or any other forms of CJD that we know of?"Professor DeArmond said.
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  The theory has been put forward by a leading American scientist, Professor Stephen DeArmond, from the University of California at San Francisco.
  
  He said it could explain why relatively few people had been struck down with the illness so far and why so many of those who had were under the age of 35.
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  Now, Professor DeArmond, one of the world's leading prion experts, has told the BBC that inflammation in the throat area of victims could be the key factor.
  
  "All I am trying to do is search for something that would get the protein into the lymphoreticular system, particularly into the tonsils, and certainly some irritation there, injury or inflammation, might have been one way that these 90-odd people were unlucky," he said.
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  But Professor DeArmond said serious consideration was now being given to the idea that the tonsils were the route through which the primary infection from cattle to humans occurred.
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  With perhaps 30% to 40% of the British population having the genetic make-up susceptible to vCJD infection, and so many contaminated meals eaten over the years, Professor DeArmond said one could have expected many more victims to have emerged by now.
  
  Age profile
  
  However, if sore throats had acted as a contributory, but limiting, factor, it might also explain the age profile of vCJD victims.
  
  "Young people go through a lot of colds and sore throats that you become immune to later in life," Professor DeArmond said.
  
  "As you get older, you experience more viruses and you reach a stage where you become less susceptible to these problems."
  
  Researchers in the UK said the ideas expressed by Professor DeArmond were plausible but nothing had been proven.
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  If these experiments are successful, they could lead to an effective treatment for spongiform diseases in humans within 10 years, Professor DeArmond said.

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  www.mad-cow.org/UKCJD/CJD_news42.html - [Cached Version]
  Published on: 2/23/2001    Last Visited: 12/11/2007  

  "I think it's reasonable that people are worried," says Stephen DeArmond, a UC San Francisco neuropathologist who collaborated on the 1997 Nobel Prize-winning research on the agent that causes BSE.
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  "We don't have the tests yet to verify that there is no problem [in our herds]," says DeArmond of UC San Francisco.

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  www.agec.org/programs/conferences/BP_Alzheimers/speaker - [Cached Version]
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  Stephen DeArmond, MD, PhDProfessor of Pathology (Neuropathology)Department of PathologyUniversity of California San Francisco

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  61st Symposium: Function and Dysfunction in the... - [Cached Version]
  Published on: 3/13/1996    Last Visited: 6/29/2004  

  Stephen DeArmond, University of California, San Francisco

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  AMA (Medical Science) AMA Science Reporters Conference - [Cached Version]
  Published on: 10/25/2001    Last Visited: 10/25/2001  

  Stephen J. DeArmond , M.D. , Ph.D. , professor of pathology , University of California , San Francisco , Calif.
  
  11 : 30 – 12 : 00 p.m. Using Antigen Processing by Tumors for Treatment

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  AgWeb - Special Interest Groups - Article - [Cached Version]
  Published on: 1/11/2004    Last Visited: 1/11/2004  

  Japan already does that, and Europe tests every animal older than 30 months (the age at which the incidence of BSE starts to climb), says Dr. Stephen De Armond, a neuropathologist at the University of California, San Francisco, and an authority on BSE.

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  Ageless Design, Alzheimers Daily News Service - [Cached Version]
  Published on: 1/3/2004    Last Visited: 11/3/2004  

  "We've already started receiving biological samples from autopsied patients," said Steven DeArmond, MD, PhD, UCSF professor of pathology and neuropathology.

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  Alliance Pharmaceutical Corp. Press Releases. - [Cached Version]
  Published on: 6/24/1999    Last Visited: 9/21/2003  

  Creutzfeldt-Jakob disease is rare, but the new variety of the illness surfaced in Britain about 5 years after the peak of an epidemic of mad cow disease, a similar illness formally known as bovine spongiform encephalopathy (BSE), according to one of the authors of the new study, Dr. Stephen J. DeArmond, of the University of California, San Francisco.Based on the coincidence, many experts suspected that the new variety of Creutzfeldt-Jakob disease was passed on to people who ate meat taken from cattle with mad cow disease, but there has been no direct scientific proof, DeArmond told Reuters Health in an interview.
  
  Now, DeArmond and his colleagues have shown that the disease could have passed from cows to people.... "Our findings provide the most compelling evidence to date that prions from cattle with BSE have infected humans and caused fatal neurodegeneration," the researchers write in the December 21st issue of the Proceedings of the National Academy of Sciences.
  
  "This is the first direct evidence that the mad cow disease was the source of the prions that caused the new variant (of Creutzfeldt-Jakob disease) in Great Britain," DeArmond said.

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  Alzheimer's Disease, Other Dementias Target of Major... - [Cached Version]
  Published on: 6/25/2004    Last Visited: 7/4/2004  

  Meanwhile, biological specimens (brain tissue from biopsies and autopsies) correlated with diagnostic, clinical, neuropsychiatric and genetic information will be sent to the Neuropathology Core, directed by Steven DeArmond, MD, PhD, UCSF professor of pathology and neuropathology.Once there, specimens will be transferred to scientists carrying out studies on specific forms of dementia, from Alzheimer's disease, to frontotemporal dementia, to prion diseases.
  
  The excitement is palpable."We've already started receiving biological samples from autopsied patients," said a swiftly moving DeArmond recently, as he passed through the halls on Parnassus Ave., one of the sites of the research.DeArmond is interested in the mechanisms of prion diseases and in identifying targets for treatment.

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