Dr. Olivier Dapremont This is Me

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1. 1. Southern Medical Association Content: In the Loop: Continuous Chromatography for Chiral (and Other) Separations

   sma.mediwire.com/main/Default. - [Cached]

   Published on: 5/2/2006   Last Visited: 3/31/2008

   Olivier Dapremont, AFC's director of chromatographic separations, points out that these analytical methods are, in fact, well-worked-out separations that could potentially be scaled up to process scale. "They already have a very efficient method for purifying the product," Dapremont says, "but they don't necessarily realize that."
   ...
   As Dapremont sees it, the pharma industry is still in the early stages of understanding and adopting SMB as a production technique, though activity has accelerated over the past three or four years.
   ...
   Dapremont emphasizes that multicolumn continuous chromatography has applications beyond chiral separations. The plant's 6 X 75-mm SMB system is dedicated to the company's cytotoxics production, manufacturing chemotherapeutics. It is used to purify paclitaxel (Taxol) from partially purified extracts of Canadian yew for Bioxel Pharma (Sainte-Foy, Qubec, Canada, www.bioxelpharma.com).
   
   These are complex mixtures of closely related compounds, mixtures that change according to the season in which the plant material is harvested. Dapremont calls this a typical case for chromatography, which can be optimized to deliver any two out of the list of three desirable performance characteristics: purity, yield, and speed.
   ...
   With other approaches, Dapremont says, "You can lose 20 percent of your product to remove one percent of impurity."

2. 2. www.specchemonline.com

   www.specchemonline.com/shownew - [Cached]

   Published on: 6/15/2006   Last Visited: 6/18/2006

   "We are looking at increasing our capabilities in energetic chemistries," notes Olivier Dapremont, director of chromatographic separations.
   ...
   "To achieve these levels through crystallisation usually means that a large amount of the desired isomer must be lost.Chromatography is highly efficient, often the undesired isomer or other impurities can be recovered as well," Dapremont explains.
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   Olivier Dapremont Manager, Sales and Marketing PO Box 1718 Rancho Cordova CA 95741, US Tel: +1 800 311-9668 E-mail: olivier.dapremont@aerojet.com Bioxel International

3. 3. Orthopedic Surgery Content: In the Loop: Continuous Chromatography for Chiral (and Other) Separations

   orthopedicsurgery.mediwire.com - [Cached]

   Published on: 5/2/2006   Last Visited: 2/2/2007

   Olivier Dapremont, AFC's director of chromatographic separations, points out that these analytical methods are, in fact, well-worked-out separations that could potentially be scaled up to process scale. "They already have a very efficient method for purifying the product," Dapremont says, "but they don't necessarily realize that."
   ...
   As Dapremont sees it, the pharma industry is still in the early stages of understanding and adopting SMB as a production technique, though activity has accelerated over the past three or four years.
   ...
   Dapremont emphasizes that multicolumn continuous chromatography has applications beyond chiral separations. The plant's 6 X 75-mm SMB system is dedicated to the company's cytotoxics production, manufacturing chemotherapeutics. It is used to purify paclitaxel (Taxol) from partially purified extracts of Canadian yew for Bioxel Pharma (Sainte-Foy, Québec, Canada, www.bioxelpharma.com).
   
   These are complex mixtures of closely related compounds, mixtures that change according to the season in which the plant material is harvested. Dapremont calls this a typical case for chromatography, which can be optimized to deliver any two out of the list of three desirable performance characteristics: purity, yield, and speed.
   ...
   With other approaches, Dapremont says, "You can lose 20 percent of your product to remove one percent of impurity."