www.medpagetoday.com/PublicHealthPolicy/Genetics/tb/608 -
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Published on: 7/4/2007
Last Visited: 7/5/2007
In an accompanying editorial, John Collins, M.D., of Dalhousie University in Halifax, Nova Scotia, said that for every nine women who use three cycles of IVF, there would be one more live birth if genetic screening had not been used, on the basis of data from the study.
Because about 8% of pregnancies established by IVF are lost after 12 weeks, the use of on-going pregnancy at 12 weeks as the primary outcome "in my opinion is a design flaw," Dr. Collins said.
Nevertheless, he added, live births were analyzed as a secondary outcome and the results are sufficiently strong to rule out genetic screening for chromosomal abnormalities "solely because of advanced maternal age."
For other indications -- such as recurrent unexplained miscarriage and recurrent implantation failure -- the issue is still up in the air, he said, but the procedure should only be used in clinical trials designed to answer the question.
The research was supported by the Netherlands Organization for Health Research and Development.The authors reported no relevant financial links.
Dr. Collins reports financial links with Organon Canada, Ferring, NV Organon, Procter & Gamble, BioSymposia (previously Serono Symposia International), and Institut Biochimique.