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This profile was automatically generated using 6 references found on the Internet. This information has not been verified. Learn more...
This profile was automatically generated using 6 references found on the Internet. This information has not been verified. Learn more...
Employment History
View...View all 6 references Web References
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1. Canadians for Health Research - Les Canadiens pour la Recherche Medicale - Single ROTW
www.chrcrm.org/main/modules/pa - [Cached]Published on: 8/24/2005 Last Visited: 7/2/2008
Dr. Claude AsselinUniversité de Sherbrooke
Dr. Claude Asselin is professor at the department of Anatomy and Cell Biology of the "Faculté de médecine et des sciences de la santé" at the Université de Sherbrooke.He is also vice-dean of Graduate Studies since January 2004.He earned his B.Sc. (1977) and his M.Sc. (1981) in microbiology from Université Laval and his Ph.D. in microbiology from the Université de Sherbrooke (1985).He worked as a post-doctoral fellow on the transcriptional regulation of the c- myc proto-oncogene in the laboratory of Dr Kenneth B. Marcu (State University of New York at Stony Brook) and obtained a National Cancer Institute of Canada fellowship (1986-1989).Dr Asselin began his career as assistant professor in 1989, and was promoted associate professor in 1995 and full professor in 2000.One research assistant, three M.Sc. and three Ph.D. students are part of his research group.Dr Asselin's research is supported by the Crohn's and Colitis Foundation of Canada, the Natural Sciences and Engineering Research Council of Canada and the Canadian Institutes of Health Research.He is also responsible of a team grant from the " Fonds pour la formation de chercheurs et l'aide à la recherche " and from the " Fonds de la recherche en santé du Québec ". He participated in many granting agencies committees.
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In the last years, Dr Asselin has been interested in understanding how intestinal epithelial cells are altered in response to inflammatory stimuli, and how differentiation modifies their response to these stimuli.The main projects revolve around transcriptional regulation and the establishment of epigenetic modifications (acetylation) during the inflammatory response.Two classes of pro-inflammatory transcription factors, namely C/EBPs and NF-?B, and targets of these transcription factors, such as acute phase protein genes, are considered.The effect of transcription factors involved in intestinal epithelial cell differentiation, cdx2 and HNF-4, on the inflammatory response is investigated.Recent data suggest that indeed, cell differentiation modifies the intestinal epithelial cell response to inflammatory stimuli.
Dr Asselin's research uses many cellular and molecular biology techniques including cell culture, electrophoretic mobility shift assays, chromatin immunoprecipitation, transfections, retroviral infection, cloning, site-directed mutagenesis, protein interaction methods, micro-arrays.His work could help identify new therapies for inflammatory bowel disease.
For further information, please contact Dr. Claude Asselin at 819-564-5276 or Claude.Asselin@USherbrooke.ca -
2. Canadians for Health Research - Les Canadiens pour la Recherche Medicale - Researcher of the Week (Small)
www.chrcrm.org/main/modules/pa - [Cached]Last Visited: 7/2/2008
Dr. Claude Asselin Université de Sherbrooke -
3. www.chrcrm.org
www.chrcrm.org/main/modules/pa - [Cached]Published on: 8/24/2005 Last Visited: 4/7/2007
Dr. Claude AsselinUniversité de Sherbrooke
Dr. Claude Asselin is professor at the department of Anatomy and Cell Biology of the "Faculté de médecine et des sciences de la santé" at the Université de Sherbrooke.He is also vice-dean of Graduate Studies since January 2004.He earned his B.Sc. (1977) and his M.Sc. (1981) in microbiology from Université Laval and his Ph.D. in microbiology from the Université de Sherbrooke (1985).He worked as a post-doctoral fellow on the transcriptional regulation of the c- myc proto-oncogene in the laboratory of Dr Kenneth B. Marcu (State University of New York at Stony Brook) and obtained a National Cancer Institute of Canada fellowship (1986-1989).Dr Asselin began his career as assistant professor in 1989, and was promoted associate professor in 1995 and full professor in 2000.One research assistant, three M.Sc. and three Ph.D. students are part of his research group.Dr Asselin's research is supported by the Crohn's and Colitis Foundation of Canada, the Natural Sciences and Engineering Research Council of Canada and the Canadian Institutes of Health Research.He is also responsible of a team grant from the " Fonds pour la formation de chercheurs et l'aide à la recherche " and from the " Fonds de la recherche en santé du Québec ". He participated in many granting agencies committees.
...
In the last years, Dr Asselin has been interested in understanding how intestinal epithelial cells are altered in response to inflammatory stimuli, and how differentiation modifies their response to these stimuli.The main projects revolve around transcriptional regulation and the establishment of epigenetic modifications (acetylation) during the inflammatory response.Two classes of pro-inflammatory transcription factors, namely C/EBPs and NF-?B, and targets of these transcription factors, such as acute phase protein genes, are considered.The effect of transcription factors involved in intestinal epithelial cell differentiation, cdx2 and HNF-4, on the inflammatory response is investigated.Recent data suggest that indeed, cell differentiation modifies the intestinal epithelial cell response to inflammatory stimuli.
Dr Asselin's research uses many cellular and molecular biology techniques including cell culture, electrophoretic mobility shift assays, chromatin immunoprecipitation, transfections, retroviral infection, cloning, site-directed mutagenesis, protein interaction methods, micro-arrays.His work could help identify new therapies for inflammatory bowel disease.
For further information, please contact Dr. Claude Asselin at 819-564-5276 or Claude.Asselin@USherbrooke.ca
