Dr. Nadir Askenasy This is Me

Education

 Web References

1. 1. Technology Review - Off the Wire

   www.technologyreview.com/offth - [Cached]

   Published on: 3/22/2002   Last Visited: 3/30/2002

   "It has been shown that engraftment of allogeneic bone marrow cells (BMC) induces tolerance to antigen-matched organs, and infusion of a megadose of cells improves the success of engraftment of T cell-depleted BMC," explained Dr. Nadir Askenasy, working with Carnegie Mellon University's Center for Light Microscope, Imaging and Biotechnology in Pittsburgh and the University of Louisville's Institute for Cellular Therapeutics in Louisville, Kentucky.
   
   Localized BMC grafts, in particular those administered using isolated limb perfusion (IL), can produce tolerogenic effects more readily than conventional transplants, Askenasy said.
   
   The results of intrabone marrow injections (IB) and IL-administered grafts in mice were compared with those achieved using marrow cells delivered through the standard intravenous route. Almost all of the mice studied showed tolerance toward skin grafts from the marrow cell donor, regardless of the method of graft delivery, study data showed.
   
   However, while IB and i.v. grafts quickly dissipated over a wide area, IL grafts remained localized, according to the report. By remaining in a small area, normal IL stem cell doses were able to act as megadoses, enhancing the engraftment potential of T cell-depleted marrow infusions.
   
   ...
   "The megadose effect achieved by inoculation of a small hemopoietic space improved engraftment of T cell-depleted BMC," Askenasy concluded. "This approach may have clinical applications."
   
   The corresponding author for this report is Nadir Askenasy, PhD, Frankel Laboratory of Bone Marrow Transplantation, Center of Pediatric Hematology Oncology, Schneider Children's Medical Center of Israel, 14 Kaplan Street, Petach Tikva, 49202, Israel. E-mail: anadir@012.net.il.
   
   A search at www.NewsRx.net using the terms "bone marrow transplantation" and "stem cell transplantation" yielded 169 articles in 28 specialized reports.
   
   Key points reported in this study include: * Localized bone marrow grafts can efficiently produce tolerance to skin grafts from the same donor in animal models * Marrow stem cell infusions delivered by isolated limb perfusion remain in a small area, enabling them to act as megadoses * This megadose effect enables such grafts to maintain the same engraftment efficiency after T-cell depletion * The engraftment efficiency of nonlocalized grafts dropped by as much as 35% after T-cell depletion This article was prepared by Blood Weekly editors from staff and other reports.
   
   To see more of the NewsRx.com, or to subscribe, go to http://www.newsrx.com .

2. 2. Technology Review - Off the Wire

   www.techreview.com/offthewire/ - [Cached]

   Published on: 3/22/2002   Last Visited: 3/23/2002

   "It has been shown that engraftment of allogeneic bone marrow cells (BMC) induces tolerance to antigen-matched organs, and infusion of a megadose of cells improves the success of engraftment of T cell-depleted BMC," explained Dr. Nadir Askenasy, working with Carnegie Mellon University's Center for Light Microscope, Imaging and Biotechnology in Pittsburgh and the University of Louisville's Institute for Cellular Therapeutics in Louisville, Kentucky.
   
   Localized BMC grafts, in particular those administered using isolated limb perfusion (IL), can produce tolerogenic effects more readily than conventional transplants, Askenasy said.
   
   The results of intrabone marrow injections (IB) and IL-administered grafts in mice were compared with those achieved using marrow cells delivered through the standard intravenous route. Almost all of the mice studied showed tolerance toward skin grafts from the marrow cell donor, regardless of the method of graft delivery, study data showed.
   
   However, while IB and i.v. grafts quickly dissipated over a wide area, IL grafts remained localized, according to the report. By remaining in a small area, normal IL stem cell doses were able to act as megadoses, enhancing the engraftment potential of T cell-depleted marrow infusions.
   
   ...
   "The megadose effect achieved by inoculation of a small hemopoietic space improved engraftment of T cell-depleted BMC," Askenasy concluded. "This approach may have clinical applications."
   
   The corresponding author for this report is Nadir Askenasy, PhD, Frankel Laboratory of Bone Marrow Transplantation, Center of Pediatric Hematology Oncology, Schneider Children's Medical Center of Israel, 14 Kaplan Street, Petach Tikva, 49202, Israel. E-mail: anadir@012.net.il.
   
   A search at www.NewsRx.net using the terms "bone marrow transplantation" and "stem cell transplantation" yielded 169 articles in 28 specialized reports.
   
   Key points reported in this study include: * Localized bone marrow grafts can efficiently produce tolerance to skin grafts from the same donor in animal models * Marrow stem cell infusions delivered by isolated limb perfusion remain in a small area, enabling them to act as megadoses * This megadose effect enables such grafts to maintain the same engraftment efficiency after T-cell depletion * The engraftment efficiency of nonlocalized grafts dropped by as much as 35% after T-cell depletion This article was prepared by Blood Weekly editors from staff and other reports.
   
   To see more of the NewsRx.com, or to subscribe, go to http://www.newsrx.com .