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   Published on: 4/27/2001   Last Visited: 10/30/2001

   Rhesus monkeys were used along with a special Simian/Human Immunodeficiency Virus developed by a group of research labs , including M.D. Anderson. M.D. Anderson's SHIV development work was supported in part by BioQuest.
   
   In the trial , test animals were vaccinated with the cell-mediated immunity agent and subsequently challenged with live SHIV. Compared to control animals , viral levels in plasma in treated animals were reduced more than 1 , 000-fold within three weeks after challenge with virus. In non-treated control animals , the CD-4 positive T-cell counts dropped at least 90% while in treated animals the change in CD-4 positive T-cell counts ranged from 0 to 10% with one animal showing a maximum 30% reduction. Now , some eighteen months later , vaccinated animals are continuing to show undetectable viral loads , no evidence of the development of resistant viral strains , and no progression to AIDS.
   ...
   Francis E. O'Donnell , Jr. , M.D. serves as a director of Biokeys , Inc. and was Biokeys' founder.