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This profile was last updated on 11/18/15  and contains information from public web pages and contributions from the ZoomInfo community.

Prof. William G. Fairbrother

Wrong Prof. William G. Fairbrother?

Associate Professor

Phone: (401) ***-****  
Email: f***@***.edu
Brown University
45 Prospect Street Box 1876
Providence , Rhode Island 02912
United States

Company Description: At Brown, the ACRIN Biostatistics and Data Management Center provides leadership and sup-port in the design, implementation, and analysis of network studies that...   more

Employment History

  • Postdoctoral Research Associate
    Brown University
  • Director of Graduate Studies , Associate Professor , MCB Department
    Brown University
  • Associate Professor - Biology Department
    Bio Med Molecular


  • PhD
13 Total References
Web References
Search Results - william fairbrother, 4 June 2013 [cached]
Affiliation:William Fairbrother, PhD, Associate Professor of Biology Department of Bio Med Molecular, Cellular Biology Biochemistry Brown University Providence, RI Brief Description: The future trend is for personalized medicine therapies for patients; these are therapeutics tailored to one's genome. In this way, vaccines and other trea... Published: Sep 27, 2013 | Inventor(s): William Fairbrother
Principal Investigators: William Fairbrother, PhD, Associate Professor - Biology Department of Bio Med Molecular, Cellular Biology Biochemistry Benjamin Raphael, PhD, Assistant Professor - Computer Science Department of Computer Science Brown University Providence, RI Brief Description: Gene splicing of nucleic acid DNA sequences i...
Published: Oct 7, 2011 | Inventor(s): William Fairbrother, Benjamin Raphael, Luciana Ferraris, Kian Huat Lim
National Ataxia Foundation - National Ataxia Foundation Research, 15 Aug 2014 [cached]
William G. Fairbrother, Ph.D. Research NAF Research 2014
William G. Fairbrother, Ph.D.
Brown University, Providence, RI
Technology - Genetic Variation and RNA binding proteins: tools and techniques to detect functional polymorphisms (Case 2251), 27 Sept 2013 [cached]
William Fairbrother, PhD, Associate Professor of Biology
Department of Bio Med Molecular, Cellular Biology Biochemistry
Brown University
William Fairbrother
Bio-IT World | According to a ... [cached]
Bio-IT World | According to a paper published in the Proceedings of the National Academy of Sciences this week, nearly one third of the mutations listed in the Human Gene Mutation Database (HGMD) may be caused by splicing errors in mRNA. “Splicing mutations are already known to be a large fraction, but we’re saying they are even more,†said William Fairbrother, assistant professor of biology at Brown University and senior author of the study. 6/12/2011 6:52:06 AM
Using a technology he ..., 6 Aug 2011 [cached]
Using a technology he invented, Brown researcher William Fairbrother (pictured center) and colleagues have discovered new molecular interactions in the process that will help regenerative medicine researchers better understand pluripotency.
In a study, Fairbrother's team showed that different proteins called transcription factors compete and cooperate in the cells to produce complex bindings along crucial sequences of DNA. This game of molecular "capture the flag," played in teams and amid shifting alliances, appears to be a necessary part of what determines whether stem cells retain their pluripotency and whether specialized, or differentiated, cells can regain it.
In recent years scientists have reported spectacular successes in turning fully differentiated cells back into pluripotent stem cells, a process called reprogramming. But the animals derived from these cells often suffer higher rates of tumors and other problems, Fairbrother said. The reason may be because the complex details of the reprogramming process haven't been fully understood. He said there are many misconceptions about how reprogramming transcription factors interact with DNA.
"Most people think of a protein binding to DNA as a single, surgical thing where you have this isolated binding event," Fairbrother said. "But in fact we show that sometimes these binding events occur over hundreds of nucleotides so they seem more like great greasy globs of proteins that are forming. In addition, the proteins interact with each other, diversifying their function by appearing in complexes with different partners at different places."
By employing a high-throughput, high-resolution binding assay that he's dubbed MEGAShift, Fairbrother and his colleagues, who include pathology researchers from the University of Utah School of Medicine, were able to analyze the interactions of several key transcription factors in a region of 316,000 letters of DNA with a resolution as low as 10 base pairs. Through hundreds of thousands of array measurements, lead authors Luciana Ferraris (pictured left) and Allan Stewart, Fairbrother, Alec DeSimone (pictured right), and the other authors learned of previously unspotted patterns of protein interactions.
Fairbrother said.
"Who binds next to a protein is a determinant of who ends up binding to a sequence," Fairbrother said.
With support from the National Institutes of Health, Fairbrother's group is also applying MEGAShift to other questions, including how protein-protein interactions affect the formation of RNA-protein complexes, which can be even more complicated than binding DNA.
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