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38 Brown Street Box R
Providence, Rhode Island 02912
Located in historic Providence, Rhode Island and founded in 1764, Brown University is the seventh-oldest college in the United States. Brown is an independent, coeducational Ivy League institution comprising undergraduate and graduate programs, plus the ... more
Associate Professor - Biology Department
Bio Med Molecular
National Ataxia Foundation - National Ataxia Foundation Research
Technology - Genetic Variation and RNA binding proteins: tools and techniques to detect functional polymorphisms (Case 2251)
Department of Bio Med Molecular, Cellular Biology Biochemistry
In a study, Fairbrother's team showed that different proteins called transcription factors compete and cooperate in the cells to produce complex bindings along crucial sequences of DNA.
This game of molecular "capture the flag," played in teams and amid shifting alliances, appears to be a necessary part of what determines whether stem cells retain their pluripotency and whether specialized, or differentiated, cells can regain it.
In recent years scientists have reported spectacular successes in turning fully differentiated cells back into pluripotent stem cells, a process called reprogramming.
But the animals derived from these cells often suffer higher rates of tumors and other problems, Fairbrother said.
The reason may be because the complex details of the reprogramming process haven't been fully understood.
Add that to the 15 percent already believed to affect splicing of mRNA, and nearly one in three mutations in the HGMD may owe at least part of their harmful results-hundreds of hereditary diseases-to the way in which they cause splicing errors.
"Splicing mutations are already known to be a large fraction, but we're saying they are even more," Fairbrother says.
Needham Market Football Club
Southern Tier Economic Growth Inc
Aegis Group plc