Stanford University, located between San Francisco and San Jose in the heart of California's Silicon Valley, is one of the world's leading teaching and research universities. Since its opening in 1891, Stanford has been dedicated to finding solutions to b
Dr. Wes Ashford became the chief medical officer of Neurotez in 2007.Dr. Ashford is Senior Research Scientist at the Stanford / VA Alzheimer Center.He is involved in the coordination of several clinical trials sponsored by the NIH and corporations.
He previously served as the Lead Investigator in the PET scan project and the first double-blind study of a cholinesterase inhibitor to treat Alzheimer's Disease among others.Dr. Ashford is leading an international group of scientists to advocate for wide-spread screening for dementia and Alzheimer's disease.He has been developing dementia measurement tools and screening tests that can be used for early detection of this prevalent condition and applied to the rapid and precise assessment of the efficacy of experimental treatments.
Prior to joining Stanford/ VA in 2003, he served as faculty at Southern Illinois University, the University of California, Davis, and the University of Kentucky, reaching the rank of tenured Associate Professor.He also directed the Geriatric Psychiatry Clinic at UCLA between 1980 and 1985 and the Lexington VAMC Memory Disorders Clinic.
His seminal work includes application of the basic physical principle of Relative-Time to dementia severity measurement, extended to the fields of Alzheimer's disease and genetics.
In addition, he originally proposed the now widely accepted theory of neuroplasticity as the vulnerable factor in Alzheimer's disease.
In 1989 he conceived the first application of Modern Test Theory in the field of Medicine using Item Characteristic Curve analysis to explain the properties of a cognitive test that has been popular for measuring dementia severity.
Earlier, his PhD dissertation was a finalist for the Donald B. Lindsley Prize of the Society for Neuroscience, as the first to show physiologically how the brain uses massive parallel distributed processing to analyze information.
Dr. Ashford attended UCLA attaining an M.D. degree, a Ph.D. in Neuroscience and finishing his psychiatry residency.He obtained his BA from the University of California, Berkeley.
Another new member of the team is Dr. Wes Ashford, senior scientist at the Stanford/VA NIH Alzheimer's Center, whose expertise is neuropsychological testing and the early incidence of Alzheimer's Disease.
Wes has a B.S. from UC-Berkeley, M.D. from UCLA-Geffen School of Medicine, and a Ph.D. in Neuroscience, also from UCLA.
Here is a summary of Dr. Ashford's AlzForum' presentation on genetic risk factors for Alzheimer's Disease:
The specific Gompertz parameters underlying AD are not understood, but even so, it is clear that ApoE genotype changes this curve, Ashford said.
ApoE exerts its main effect by influencing when people get AD, Ashford said.
In a clinic population, the E4/4 genotype reduces the mean age of onset to 68 from 74 in E3/3 carriers.
Environmental factors and nonspecific genes also play a role in determining AD risk and may, in fact, have a relatively greater effect in very old age (see also Silverman et al., 2003).
Ashford suggested that the E2 and E3 alleles, which evolved from the ancestral E4, better support the remodeling of dendrites and minimize neuronal stress over time (see also Live Discussion).
"Detecting problems early on is helpful, because there are reversible conditions that impair memory such as vitamin deficiency, metabolic disorders or hormone imbalances," says Wes Ashford, M.D., a senior research scientist at the Stanford University School of Medicine/VA Alzheimer's Center in Palo Alto, California.
Memory problems can begin as early as age 30 in some people, say Dr. Ashford.
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Dr. Wes Ashford is a researcher in memory and the brain at Stanford University and the U.S. V.A. in Palo Alto and one of the leading authorities on Alzheimer's Disease and its causes.He received his M.D. from the David Geffen School of Medicine at UCLA.His publications have appeared in the Journal of Alzheimer's Disease, JAMA and others.
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