Another new member of the team is Dr. Wes Ashford, senior scientist at the Stanford/VA NIH Alzheimer's Center, whose expertise is neuropsychological testing and the early incidence of Alzheimer's Disease.
Wes has a B.S. from UC-Berkeley, M.D. from UCLA-Geffen School of Medicine, and a Ph.D. in Neuroscience, also from UCLA.
Here is a summary of Dr. Ashford's
AlzForum' presentation on genetic risk factors for Alzheimer's Disease:
The specific Gompertz parameters underlying AD are not understood, but even so, it is clear that ApoE genotype changes this curve, Ashford
exerts its main effect by influencing when people get AD, Ashford
In a clinic population, the E4/4 genotype reduces the mean age of onset to 68 from 74 in E3/3 carriers.
Environmental factors and nonspecific genes also play a role in determining AD risk and may, in fact, have a relatively greater effect in very old age (see also Silverman et al., 2003).
suggested that the E2 and E3 alleles, which evolved from the ancestral E4, better support the remodeling of dendrites and minimize neuronal stress over time (see also Live Discussion).