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Wrong Todd Golde?

Todd E. Golde

Director McKnight Brain Institute

University of Florida

HQ Phone:  (904) 588-1800

Direct Phone: (352) ***-****direct phone

Email: t***@***.edu

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I agree to the Terms of Service and Privacy Policy. I understand that I will receive a subscription to ZoomInfo Community Edition at no charge in exchange for downloading and installing the ZoomInfo Contact Contributor utility which, among other features, involves sharing my business contacts as well as headers and signature blocks from emails that I receive.

University of Florida

2015 North Jefferson Street

Jacksonville, Florida,32206

United States

Company Description

The University of Florida prides itself on its research facilities and encourages all students to partake, even during their freshman and sophomore years. For the 2015-2016 school year, UF received a record $724 million in funding for research projects. The sc...more

Find other employees at this company (45,794)

Background Information

Employment History

Director

UF Health Shands Hospital


Chair and Professor

Mayo Clinic


Assistant Professor

University of Pennsylvania


Affiliations

Alzheimer's Association

MSAC Member


ProMIS Neurosciences Inc

Advisory Boards Member


BrightFocus Foundation

Committee Member


American Health Assistance Foundation

Committee Member


ahaf.com

Committee Member


Education

M.D.

Case Western Reserve University


M.D.

Mayo Medical School


M.D.

National Institutes of Health-led initiative


MD

Institute for Systems Biology


Ph.D.

University of Florida


PhD

Mayo Clinic College of Medicine


doctoral degrees

Case Western Reserve University


Web References(148 Total References)


Medical and Scientific Advisory Council MSAC | Alzheimer's Association

www.alz.org [cached]

Todd E. Golde, Ph.D., M.D.
University of Florida, Gainesville, Fla., Director of the Center for Translational Research in Neurodegenerative Disease, Professor of Neuroscience


Directors | UF Health, University of Florida Health

ufhealth.org [cached]

Todd Golde, M.D., Ph.D.
Todd Golde, M.D., Ph.D. Executive Director McKnight Brain Institute


Ellison Medical Foundation Senior Scholars in Aging for 2010 | The Lawrence Ellison Foundation

www.ellisonfoundation.org [cached]

Todd E. Golde, M.D., Ph.D.
University of Florida


Inflammation Helps Microglia Clear Amyloid from AD Brains | ALZFORUM

www.alzforum.org [cached]

Todd Golde of University of Florida, Gainesville, reported that the pro-inflammatory cytokine IL-6 stimulates gliosis, enhancing A phagocytosis in transgenic mice (see Chakrabarty et al., 2010).
Both Golde and Town separately found that the anti-inflammatory cytokine IL-10 worsens amyloid pathology and cognition in mice (see Feb 2015 conference news). Not all studies agree, however, with other researchers reporting negative effects from different pro-inflammatory cytokines (see Nov 2012 news). For his current research, Golde and colleague Yona Levites wondered how the inflammatory state of the brain might affect AD immunotherapy. Moreover, the presence of IL-10 blunted the benefits of antibody treatment, Golde reported. The data suggest that the brain's underlying immune status can modulate the outcome of immunotherapy, Golde said. He noted that immune activation follows the "Goldilocks Principle"-it needs to be just right. Recent mouse data point to benefits from turning up the immune system to run a little hotter in the AD brain, Golde said. An audience member wondered if the findings will translate to people, since both IL-6 and IL-10 have been reported to be elevated in AD brain. However, Golde noted that most of those data come from postmortem brains. People with AD often die from infections such as sepsis or pneumonia, which could alter the immune status of the brain. Researchers need to assess the level of innate immune factors in living patients, he suggested. If the data show that immunotherapy does require pro-inflammatory factors to be most effective, researchers might borrow a technique from the cancer field and create "chemobodies" that combine an antibody with another molecule to accomplish both goals at once, Golde suggested.


Introducing Todd E. Golde, M.D., Ph.D.

facingfacialpain.org [cached]

Introducing Todd E. Golde, M.D., Ph.D.
Introducing Todd E. Golde, M.D., Ph.D. Todd E. Golde, M.D., Ph.D., is currently the Director of the Center for Translational Research in Neurodegenerative Disease at University of Florida (Department of Neuroscience) where he directs a robust program of scientific discovery aimed at translating basic discoveries in neurodegenerative disease into diagnostics and treatments for patients. Dr. Golde has joined the Facial Pain Research Foundation research team as a Co-Investigator on the "In Search of a Cure: Finding the Brain Signature Centers that Cause Trigeminal Neuralgia". asked Dr. Golde to write a brief descriptor of his work on this Foundation Research Project.-- By Todd E. Golde, M.D., Ph.D. Drs. Neubert, Caudle, Levites and Golde have already teamed up to show that in rodent models using gene therapy vectors already available, one can easily deliver genes selectively and extremely efficientlyto the trigeminal nerve.


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