"While the industry as a whole is in the early stages of adopting flow chemistry for small-molecule API manufacturing, the early adopters and fast followers not only recognize that flow chemistry is the future of manufacturing, but also believe that they can implement it effectively," asserts Tim Jamison, professor of chemistry and incoming department head at the Massachusetts Institute of Technology (MIT) and CEO of Snapdragon Chemistry, a new company dedicated to catalyzing the adoption of continuous flow synthesis.
"Ultimately, when these companies realize the many benefits of flow chemistry, including reduced operating costs, footprint, and capital expenditures combined with improved process efficiencies, control, and product quality, investors likely will modify their expectations and demand this increased value from the industry as a whole.
The rest of the industry will then have to scramble to catch up, and the early adopters and fast followers should reap the rewards of their forward-thinking actions.
At that point, the entire industry--out of necessity to remain competitive--likely would shift its view on flow technology," he
adds that the use of flow chemistry for photochemical and electrochemical reactions is also exciting, because these reaction classes are typically difficult to carry out and control and also challenging to translate from laboratory scale to pilot or manufacturing scale, but afford significant opportunities to access completely novel chemical scaffolds and greatly streamline current synthetic routes.
In fact, the inadequate supply of scientific talent and expertise necessary to implement continuous flow technology at scale is perhaps the largest factor hindering more rapid adoption of flow chemistry for small-molecule API synthesis, according to Jamison
This shift will not occur immediately, however, and there will likely be a short- to mid-term lack of human resource supply," Jamison
Although FDA representatives recently made a number of public comments in support of continuous manufacturing in the pharmaceutical industry, from a regulatory standpoint, there remains a need to develop clear, harmonized guidelines accepted across the various regulatory authorities that will facilitate the development of continuous manufacturing routes in a manner that guarantees a consistent way to monitor/regulate their output, according to Jamison
Snapdragon Chemistry-a new company launched in early May 2015 by CEO Tim Jamison, a professor of chemistry and incoming department head at the Massachusetts Institute of Technology (MIT), with Boston University assistant professor of chemistry Aaron Beeler-intends to provide drug companies with assistance in developing flow chemistry strategies and systems.
has the capability to help a drug-maker from end-to-end in implementing continuous flow manufacturing," Jamison
Snapdragon Chemistry has already formed partnerships with companies, such as drug-discovery service provider Paraza Pharma and equipment manufacturer Zaiput Flow Technologies, to bring the most innovative and effective continuous flow solutions to clients, according to Jamison.