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2016-02-09T00:00:00.000Z

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Wrong Thomas Walther?

Prof. Thomas Walther

Head of Department

University College Cork, Ireland (UCC)

HQ Phone:

University College Cork, Ireland (UCC)

College Road

Cork,

Ireland

Company Description

UCC was established in 1845 as one of three Queen's Colleges at Cork, Galway and Belfast. The site chosen for the college is particularly appropriate given its connection with the patron saint of Cork, St Finbarr. It is believed his monastery and school s ... more

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Background Information

Employment History

Chair
Hull York Medical School

Professor
University of Hull

Web References (36 Total References)


Staff - Hull York Medical School

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Professor Thomas Walther Professor in Cardiovascular Physiology


Professor Thomas ...

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Professor Thomas Walther Professor in Cardiovascular Physiology


Molecular and vascular biology - Research at Hull York Medical School

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Professor Thomas Walther Chair in Biomedical Sciences

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Thomas Walther


Haemostasis and thrombosis - Research at Hull York Medical School

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Professor Thomas Walther Chair in Biomedical Science

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Thomas Walther


HYMS: research profile: Thomas Walther

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Professor Thomas Walther HYMS: research profile: Thomas Walther

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Group Leader: Professor Thomas Walther
Professor Thomas Walther
The main aim of Professor Thomas Walther's research is to improve the treatment of patients who suffer from cardiovascular conditions, by:
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Professor Walther's research is particularly significant in the area of combining basic and translational research to improve the prediction and treatment of cardiovascular diseases. He follows the strategy of molecular investigation, followed by evaluation in experimental models, and finally establishing proof-of-concept in humans, aiming to find new therapeutic strategies.
Examples of detailed research areas
Professor Walther is investigating the role of three different peptide systems (renin-angiotensin system, kallikrein-kinin system, and natriuretic peptide system) in the aetiology of different diseases, mainly focused on cardiovascular pathophysiology in end-organs such as the brain or heart (for instance, Walther et al., FASEB J., 2002a, 2003, 2008). Having identified the intense interactions of these systems, he is interested in finding out how an imbalance of cross-talk can influence the development of heart failure and vascular diseases (for instance, Walther et al., FASEB J., 2002b; Tschöpe et al. and Walther, Cardiovasc. Res., 2004). These investigations are especially focused on altered gene regulation, modified receptor/receptor interaction, and receptor mediated intracellular signalling.
Professor Walther has hypothesised that angiotensin II could be a mediator between homeostatic changes in the vascular perfusion bed and growth factor driven angiogenesis. This resulted in the first evidence that angiogenesis is stimulated in vivo through the AT2 receptor system. Angiotensin II acts as a humoral regulator of peripheral angiogenesis, involving two receptor subtypes with opposing actions (Walther et al., FASEB J., 2003). Current studies aim to identify the cellular progenitors (stem cells) for vascular growth and regeneration under the control of angiotensin II.
He found new receptors which interact with the renin-angiotensin system and/or kallikrein-kinin system (e.g. Santos et al. & Walther, Proc. Natl. Acad. Sci. USA, 2003 Gembardt et al & Walther, Mol. Cell. Biochem., 2008) and which have a significant impact on neuronal and hormonal control under ischemic conditions.
Professor Walther's work has advanced the understanding of the natriuretic peptide system by identifying that brain natriuretic peptide (BNP) was resistant to neutral endopeptidase digestion. This led to identification of the peptidase that is responsible for BNP degradation which in turn opens up a new possibility of using pharmacological interventions to enhance the cardioprotective actions of BNP (Pankow et al. & Walther, Circulation Research., 2007).
Another aspect of Professor Walther's research is identifying and investigating new interactions between gene products (often newly identified G protein-coupled receptors) and their importance for functional cardiovascular deregulation. By identifying an interaction between the receptors Mas and AT1, he was the first to demonstrate that a G protein-coupled receptor could act as a physiological antagonist of a previously characterised receptor. This AT1-Mas complex also has potential as a drug target for developing new therapies for cardiovascular disease (Kostenis et al. & Walther, Circulation., 2005).
Professor Walther's further research investigates the claim that receptors (which may be of different receptor families) may physically interact within the cell membrane and influence each others' signalling pathways. Most recently, his group has discovered interactions between a G protein-coupled receptor and a membrane bound guanylate cyclase and shown cross-talk between their signalling in the heart (unpublished data).
Members of Prof. Walther's research group
Publications of the last 10 years: Prof. Thomas Walther
Group Leader: Professor Walther
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Professor Walther's research group
Publications of the last 10 years: Prof. Thomas Walther

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