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This profile was last updated on 3/9/15  and contains information from public web pages and contributions from the ZoomInfo community.

Dr. Thomas B. Shea

Wrong Dr. Thomas B. Shea?

Professor and Director of Researc...

University of Massachusetts Lowell
Local Address: Lowell, Massachusetts, United States
University of Massachusetts
225 Franklin St Ste 1200
Boston , Massachusetts 02110
United States

Company Description: The University of Massachusetts Medical School, one of the fastest growing academic health centers in the country, has built a reputation as a world-class research...   more

Employment History

  • Lowell Professor
    University of Massachusetts
  • Director of the Center for Cellular Neurobiology and Neurodegeneration Research
    University of Massachusetts
  • Director
    Center for Cellular Neurobiology and Neurodegeneration Research
  • Professor and Director
    Center for Cellular Neurobiology and Neurodegeneration Research
  • Director
    UML Center for Cellular Neurobiology and Neurodegeneration Research

Board Memberships and Affiliations

  • Director


  • PhD
  • Ph.D.
184 Total References
Web References
VIC Technology Venture Development: Technology Solutions for a Better World, 20 Mar 2014 [cached]
PERCEPTIV is patented and based on seven independent, national clinical studies performed by UMASS Lowell professor Dr. Thomas Shea and his team, in which the supplement improved cognitive performance not only for healthy adults but also for those with cognitive impairment.
Sevo's cornerstone product, PERCEPTIV™, was licensed from UMass Lowell in 2012 and was developed under the leadership of UMass Lowell Professor Thomas B. Shea, Director of the Center for Cellular Neurobiology and Neurodegeneration Research.
And for Professor Thomas ..., 11 Dec 2013 [cached]
And for Professor Thomas Shea of UMass Lowell, "it" is the winning of a significant patent for his brainchild, PERCEPTIV - an over-the-counter pill that protects against cognitive decline due to aging.
The so-called "composition and methods" patent, U.S. 8,597,640, was announced by the U.S. Patent Office on Dec. 3. Put simply, it recognizes and protects PERCEPTIV's exact ingredients and their formulations, as well as what PERCEPTIV can do - offer neuro protection that improves cognitive performance.
Shea, who credited a former student, Amy Chan-Daniels, who did clinical work as part of her doctoral thesis, has been researching brain health and cognitive performance for more than 20 years.
Prusaczyk said his company's positioning is "pretty unique," in that Shea and his team did virtually all of the patent-application work.
The work was done independently, with Dr. Shea as the lead inventor.
For Shea, a cell biologist who is director of UMass Lowell's Center for Cellular Neurobiology and Neurodegeneration Research, finding a solution to brain degeneration was inspired by working at McLean Hospital in Belmont with people experiencing cognitive decline.
"We donated time, and involved lots of people across the country, and they were lucky to get lunch money," Shea said. "We had 11 sites for clinical studies, no salaries. It was academic people who love this work."
PERCEPTIV consists of a precise blend of three vitamins (folate, B12 and vitamin E) and three nutraceuticals (S-adenosyl methionine, N-Acetyl cysteine and acetyl-L-carnitine) that offer antioxidant protection to brain cells and a way to maintain brain-cell health and function.
Shea's seven independent studies have been published in scientific journals and presented at multiple international conferences, including the Alzheimer's Association International Conferences in Paris and Boston.
"Not a dime corporate-funded," Shea said, adding that the product was "signed, sealed and delivered" once Sevo agreed to license it."
Shea then check out the link ..., 15 Nov 2014 [cached]
Shea then check out the link between nutritional deficiencies of folate and vitamin e and the development of neurofibrillary tangles of tau protein, a hallmark of Alzheimer's disease.. Alzheimer's disease. In the editorial Guest Editor Thomas Shea, professor and director of the Center for Cellular Neurobiology and Neurodegeneration Research, University of Massachusetts Lowell, suggests Alzheimer's disease is a multifactorial etiology has, includes genetic and dietary risk factors, and no single risk factor can for account for all cases. Genetic predisposition pending pending an age-related critical decline in nutrition. This has the relationship between food confused Alzheimer since post malnutrition can go undetected, and even if taken, can not pay attention enough, when isolated benign.
She was a major backer of the 2007 reauthorization of the Older Americans Act , the number of programs for older people, including senior center services, meals, transportation, home care and carers financed support for those who care for older adults. She was also instrumental.
Research Shows Benefits of Apple Juice on Memory Newswise - Apple & Eve | Apple & Eve, 26 July 2010 [cached]
Such communication between nerve cells is vital for good health, not just in the brain, but throughout the body.“We anticipate that the day may come when foods like apples, apple juice and other apple products are recommended along with the most popular Alzheimer’s medications,†says Thomas Shea, Ph.D., director of the UML Center for Cellular Neurobiology and Neurodegeneration Research. he study will be published in the August issue of the international Journal of Alzheimer’s Disease. The abstract is now available online at he role of acetylcholine in the brain is not a new area of research. Alzheimer’s medication studies start with the premise that increasing the amount of acetylcholine in the brain can help to slow mental decline in people with Alzheimer's disease. Testing a similar hypothesis, the UML research team found that having animals consume antioxidant-rich apple juice had a comparable and beneficial effect. n this novel animal study at UML, adult (9-12 months) and old (2-2.5 years) mice, some specially bred to develop Alzheimer’s-like symptoms, were fed three different diets (a standard diet, a nutrient-deficient diet, and a nutrient-deficient diet supplemented with apple components (in this case, apple juice concentrate was added to their drinking water). mong those fed the apple juice-supplemented diet, the mice showed an increased production of acetylcholine in their brains. Also, after multiple assessments of memory and learning using traditional Y maze tests, researchers found that the mice who consumed the apple juice-supplemented diets performed significantly better on the maze tests.“It was surprising how the animals on the apple-enhanced diets actually did a superior job on the maze tests than those not on the supplemented diet,†remarks Dr. Shea. arlier studies by Shea’s research team had strongly suggested apples must possess a unique mix of antioxidants that improve cognition and memory via inhibition of oxidation in the brain. Those results encouraged Shea to evaluate the neurotransmitter effect, as is done in the current study. Medications given to humans with Alzheimer’s disease have been shown to inhibit the production of specific enyzmes (cholinesterase inhibitors) that break down acetylcholine in the brain. The end result in the animal study is similar â€" there are more of these critical messengers remaining in the brain to enhance memory. he results obtained were from the animals consuming moderate amounts of apple juice -comparable to drinking approximately two 8 oz. glasses of apple juice or eating 2-3 apples a day.
Pick Apples For Good Neurological Health, Says Several New Research Studies, 1 Dec 2006 [cached]
In addition to finding the improved levels of acetylcholine in their brains, "It was surprising how the animals on the apple-enhanced diets actually did a superior job on the maze tests than those not on the apple-supplemented diet," remarks Dr. Thomas Shea, who led the research.
Shea, who is the director of the UML Center for Cellular Neurobiology and Neurodegeneration, published yet another study in the December 2005 Journal of Alzheimer's Disease in which older mice (not mice with Alzheimer's like conditions) performed significantly better on memory tests than did animals whose diet was not enriched with apple products. Both of these studies, along with similar study published by Shea in the March 200 issue of Journal of Nutrition, Health and Aging strongly suggests that apples must possess a unique mix of antioxidants that improve cognition and memory via inhibition of oxidation in the brain.
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