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This profile was last updated on 1/8/14  and contains information from public web pages and contributions from the ZoomInfo community.

Dr. Thomas B. Shea

Wrong Dr. Thomas B. Shea?

Lowell Professor

Local Address: Lowell, Massachusetts, United States
University of Massachusetts
225 Franklin Street 12Th Floor
Boston, Massachusetts 02110
United States

Company Description: The University of Massachusetts Medical School, one of the fastest growing academic health centers in the country, has built a reputation as a world-class research...   more
Background

Employment History

  • Director of the Center for Cellular Neurobiology and Neurodegeneration Research
    University of Massachusetts
  • Director
    Center for Cellular Neurobiology and Neurodegeneration Research
  • Professor and Director
    Center for Cellular Neurobiology and Neurodegeneration Research
  • Director
    UML Center for Cellular Neurobiology and Neurodegeneration Research

Board Memberships and Affiliations

  • Director
    Neurodegeneration

Education

  • PhD
  • Ph.D.
194 Total References
Web References
Sevo's cornerstone product, ...
www.digitaljournal.com, 16 July 2013 [cached]
Sevo's cornerstone product, PERCEPTIV™, was licensed from UMass Lowell in 2012 and was developed under the leadership of UMass Lowell Professor Thomas B. Shea, Director of the Center for Cellular Neurobiology and Neurodegeneration Research.
Age-Related Memory Improvement Linked with Consumption of Apple Products
www.appleproducts.org, 23 Jan 2006 [cached]
"This new study suggests that eating and drinking apples and apple juice, in conjunction with a balanced diet, can protect the brain from the effects of oxidative stress - and that we should eat such antioxidant-rich foods," notes lead researcher Thomas B. Shea, Ph.D., director of the University of Massachusetts Lowell's Center for Cellular Neurobiology and Neurodegeneration Research, whose study was just published in the latest issue of the Journal of Alzheimer's Disease. Although more research is needed, Shea is excited about these brain health findings, which are encouraging for all individuals who are interested in staying mentally sharp as they age.
Using a well-established animal protocol, Shea and his research colleagues assessed whether consumption of apple juice was protective against oxidative brain damage in aging mice, damage that can lead to memory loss. "These newer findings show that there is something in apples and apple juice that protects brain cells in normal aging, much like the protection we previously saw against Alzheimer-like symptoms," says Shea.
...
"We believe that this effect is due to the apple's naturally high level of antioxidants," states Shea. Previous research with his colleagues also determined that it is not the sugar and energy content of the apple juice, but the antioxidant attributes of apple juice that are responsible for the positive effects.
JAD - Press Releases
www.j-alz.com, 26 Sept 2006 [cached]
In the lead article Guest Editor Thomas Shea, Professor and Director of the Center for Cellular Neurobiology and Neurodegeneration Research, University of Massachusetts Lowell, suggests "Alzheimer's disease has a multifactoral etiology, encompassing genetic and nutritional risk factors, and no single risk factor can account for all cases....A genetic predisposition may remain latent pending an age-related critical decline in nutrition.
...
Amy Chan and Thomas B. Shea then examine the connection between dietary deficiencies of folate and Vitamin E and the development of neurofibrillary tangles of tau protein, a hallmark of Alzheimer's disease.
Research Shows Benefits of Apple Juice on Memory Newswise - Apple & Eve | Apple & Eve
www.appleandeve.com, 26 July 2010 [cached]
Such communication between nerve cells is vital for good health, not just in the brain, but throughout the body.“We anticipate that the day may come when foods like apples, apple juice and other apple products are recommended along with the most popular Alzheimer’s medications,†says Thomas Shea, Ph.D., director of the UML Center for Cellular Neurobiology and Neurodegeneration Research. he study will be published in the August issue of the international Journal of Alzheimer’s Disease. The abstract is now available online athttp://www.j-alz.com/issues/9/vol9-3.html. he role of acetylcholine in the brain is not a new area of research. Alzheimer’s medication studies start with the premise that increasing the amount of acetylcholine in the brain can help to slow mental decline in people with Alzheimer's disease. Testing a similar hypothesis, the UML research team found that having animals consume antioxidant-rich apple juice had a comparable and beneficial effect. n this novel animal study at UML, adult (9-12 months) and old (2-2.5 years) mice, some specially bred to develop Alzheimer’s-like symptoms, were fed three different diets (a standard diet, a nutrient-deficient diet, and a nutrient-deficient diet supplemented with apple components (in this case, apple juice concentrate was added to their drinking water). mong those fed the apple juice-supplemented diet, the mice showed an increased production of acetylcholine in their brains. Also, after multiple assessments of memory and learning using traditional Y maze tests, researchers found that the mice who consumed the apple juice-supplemented diets performed significantly better on the maze tests.“It was surprising how the animals on the apple-enhanced diets actually did a superior job on the maze tests than those not on the supplemented diet,†remarks Dr. Shea. arlier studies by Shea’s research team had strongly suggested apples must possess a unique mix of antioxidants that improve cognition and memory via inhibition of oxidation in the brain. Those results encouraged Shea to evaluate the neurotransmitter effect, as is done in the current study. Medications given to humans with Alzheimer’s disease have been shown to inhibit the production of specific enyzmes (cholinesterase inhibitors) that break down acetylcholine in the brain. The end result in the animal study is similar â€" there are more of these critical messengers remaining in the brain to enhance memory. he results obtained were from the animals consuming moderate amounts of apple juice -comparable to drinking approximately two 8 oz. glasses of apple juice or eating 2-3 apples a day.
Pick Apples For Good Neurological Health, Says Several New Research Studies
www.appleproducts.org, 1 Dec 2006 [cached]
In addition to finding the improved levels of acetylcholine in their brains, "It was surprising how the animals on the apple-enhanced diets actually did a superior job on the maze tests than those not on the apple-supplemented diet," remarks Dr. Thomas Shea, who led the research.
Shea, who is the director of the UML Center for Cellular Neurobiology and Neurodegeneration, published yet another study in the December 2005 Journal of Alzheimer's Disease in which older mice (not mice with Alzheimer's like conditions) performed significantly better on memory tests than did animals whose diet was not enriched with apple products. Both of these studies, along with similar study published by Shea in the March 200 issue of Journal of Nutrition, Health and Aging strongly suggests that apples must possess a unique mix of antioxidants that improve cognition and memory via inhibition of oxidation in the brain.
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