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This profile was last updated on 9/30/15  and contains information from public web pages and contributions from the ZoomInfo community.

Dr. Thomas B. Shea

Wrong Dr. Thomas B. Shea?

Professor and Director of Researc...

University of Massachusetts Lowell
Phone: (978) ***-****  
Email: t***@***.edu
Local Address:  Lowell , Massachusetts , United States
University of Massachusetts
140 Hicks Way
Amherst , Massachusetts 01003
United States

Company Description: About the University of Massachusetts Medical School The University of Massachusetts Medical School, one of the fastest growing academic health centers in the...   more

Employment History

  • Lowell Professor
    University of Massachusetts
  • Director of the Center for Cellular Neurobiology and Neurodegeneration Research
    University of Massachusetts
  • Director
    Center for Cellular Neurobiology and Neurodegeneration Research
  • Professor and Director
    Center for Cellular Neurobiology and Neurodegeneration Research
  • Director
    UML Center for Cellular Neurobiology and Neurodegeneration Research
  • Director
    University of Massachusetts Lowell Center for Cellular Neurobiology and Neurodegeneration Research

Board Memberships and Affiliations

  • Director


  • PhD
  • Ph.D.
184 Total References
Web References
Apple juice (fresh apple juice, not ..., 30 Sept 2015 [cached]
Apple juice (fresh apple juice, not from apple-flavored chemical powder) can push production of the "memory chemical" acetylcholine; that's the way the popular Alzheimer's drug Aricept works, says Thomas Shea, Ph.D., of the University of Massachusetts. He was surprised that old mice given apple juice did better on learning and memory tests than mice that received water. A dose for humans: 16 ounces, or two to three apples a day.
UMASS Lowell professor ..., 15 Jan 2015 [cached]
UMASS Lowell professor Dr. Thomas Shea and his research team completed a Phase II Clinical Trial, in which more than 100 individuals diagnosed with Alzheimer's disease, received either the PERCEPTIV™ formulation or a placebo (without knowing which one they received).
These studies, referred to as "phase II," were funded by a grant to Dr. Shea from the Alzheimer's Association, and confirm earlier "phase I" studies, in which PERCEPTIV™ also improved memory and cognitive performance for 93 individuals with no known or suspected memory difficulties, as well as for other individuals diagnosed with Alzheimer's disease. Copies of these peer-reviewed studies, published in scientific journals, can be accessed free of charge at
The PERCEPTIV™ formulation was licensed from the University of Massachusetts Lowell by Sevo Nutraceuticals in 2012. Importantly, all of Dr. Shea's studies were completed prior to licensing and there was no corporate involvement in these clinical studies.
Sevo's cornerstone product, PERCEPTIV™, was licensed from UMass Lowell in 2012 and was developed under the leadership of UMass Lowell Professor Thomas B. Shea, Director of the Center for Cellular Neurobiology and Neurodegeneration Research.
PERCEPTIV'sâ„¢ Patented Formula for Improved Brain Health - PERCEPTIV, 11 Dec 2013 [cached]
And for Professor Thomas Shea of UMass Lowell, "it" is the winning of a significant patent for his brainchild, PERCEPTIV - an over-the-counter pill that protects against cognitive decline due to aging.
The so-called "composition and methods" patent, U.S. 8,597,640, was announced by the U.S. Patent Office on Dec. 3. Put simply, it recognizes and protects PERCEPTIV's exact ingredients and their formulations, as well as what PERCEPTIV can do - offer neuro protection that improves cognitive performance.
Shea, who credited a former student, Amy Chan-Daniels, who did clinical work as part of her doctoral thesis, has been researching brain health and cognitive performance for more than 20 years.
Prusaczyk said his company's positioning is "pretty unique," in that Shea and his team did virtually all of the patent-application work.
The work was done independently, with Dr. Shea as the lead inventor.
For Shea, a cell biologist who is director of UMass Lowell's Center for Cellular Neurobiology and Neurodegeneration Research, finding a solution to brain degeneration was inspired by working at McLean Hospital in Belmont with people experiencing cognitive decline.
"We donated time, and involved lots of people across the country, and they were lucky to get lunch money," Shea said. "We had 11 sites for clinical studies, no salaries. It was academic people who love this work."
PERCEPTIV consists of a precise blend of three vitamins (folate, B12 and vitamin E) and three nutraceuticals (S-adenosyl methionine, N-Acetyl cysteine and acetyl-L-carnitine) that offer antioxidant protection to brain cells and a way to maintain brain-cell health and function.
Shea's seven independent studies have been published in scientific journals and presented at multiple international conferences, including the Alzheimer's Association International Conferences in Paris and Boston.
"Not a dime corporate-funded," Shea said, adding that the product was "signed, sealed and delivered" once Sevo agreed to license it."
Shea then check out the link ... [cached]
Shea then check out the link between nutritional deficiencies of folate and vitamin e and the development of neurofibrillary tangles of tau protein, a hallmark of Alzheimer's disease.. Alzheimer's disease. In the editorial Guest Editor Thomas Shea, professor and director of the Center for Cellular Neurobiology and Neurodegeneration Research, University of Massachusetts Lowell, suggests Alzheimer's disease is a multifactorial etiology has, includes genetic and dietary risk factors, and no single risk factor can for account for all cases. Genetic predisposition pending pending an age-related critical decline in nutrition. This has the relationship between food confused Alzheimer since post malnutrition can go undetected, and even if taken, can not pay attention enough, when isolated benign.
She was a major backer of the 2007 reauthorization of the Older Americans Act , the number of programs for older people, including senior center services, meals, transportation, home care and carers financed support for those who care for older adults. She was also instrumental.
Pick Apples For Good Neurological Health, Says Several New Research Studies, 1 Dec 2006 [cached]
In addition to finding the improved levels of acetylcholine in their brains, "It was surprising how the animals on the apple-enhanced diets actually did a superior job on the maze tests than those not on the apple-supplemented diet," remarks Dr. Thomas Shea, who led the research.
Shea, who is the director of the UML Center for Cellular Neurobiology and Neurodegeneration, published yet another study in the December 2005 Journal of Alzheimer's Disease in which older mice (not mice with Alzheimer's like conditions) performed significantly better on memory tests than did animals whose diet was not enriched with apple products. Both of these studies, along with similar study published by Shea in the March 200 issue of Journal of Nutrition, Health and Aging strongly suggests that apples must possess a unique mix of antioxidants that improve cognition and memory via inhibition of oxidation in the brain.
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