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This profile was last updated on 1/6/16  and contains information from public web pages and contributions from the ZoomInfo community.

Dr. Thomas N. Seyfried

Wrong Dr. Thomas N. Seyfried?

Biologist

Phone: (617) ***-****  
Email: t***@***.edu
Boston College
38 Commonwealth Avenue
Chestnut Hill , Massachusetts 02467
United States

Company Description: Founded in 1863, Boston College is a coeducational university with an enrollment of 9,000 undergraduates and 4,700 graduate and professional students representing...   more
Background

Employment History

Board Memberships and Affiliations

Education

  • PhD
  • Ph.D. presenting
  • Ph.D. , Genetics and Biochemistry
    University of Illinois , Urbana
  • undergraduate degree
    University of New England
  • Master's degree , Genetics
    Illinois State University
157 Total References
Web References
Thomas Seyfried, a biologist ...
www.scientificamerican.com, 15 Dec 2015 [cached]
Thomas Seyfried, a biologist at Boston College who was not part of this study, feels that cancer is a metabolic disorder, citing the large body of evidence implicating mitochondrial dysfunction in cancer. Mitochondria-or the "powerhouses" of our cells-are where cellular energy production takes place. "There is now substantial evidence from a broad range of disciplines showing some degree of defect in the number, structure or function of mitochondria in all types of tumor cells. These mitochondrial defects cause the enhanced glucose uptake and the fermentation seen in tumor cells," Seyfried explains.
In a 2014 paper by Seyfried and colleagues published in Carcinogenesis he cites ample evidence to support his claim, including showing that a cell's tumor potential is suppressed if it is transplanted with normal mitochondria; and conversely that transferring mitochondria from tumor cells into the cytoplasm of normal cells increases the chances that those once normal cells will become cancerous. He also points out the large body of work connecting the etiological dots: Many of the mutated genes associated with cancer seem to exert their effects by impairing cellular respiration. It is also possible, Seyfried strongly feels, that transitioning from respiration to fermentation produces free radicals that cause genetic mutations associated with cancer.
Episode 16 - Dr. Thomas ...
thequantifiedbody.net, 28 Feb 2015 [cached]
Episode 16 - Dr. Thomas Seyfried
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- Dr. Thomas Seyfried
Today's guest, Dr. Thomas Seyfried, is Professor of Biology at Boston College, where he leads a research program focused on the mechanisms by which metabolic therapies such as ketogenic diets and fasting can manage chronic disease and cancer. He sits on the editorial boards of four research journals, and has over 60 published papers on cancer and metabolism.
He is the author of the review paper Cancer as a Metabolic Disease, appearing in the Journal of Nutrition and Metabolism in 2010, and of the textbook in 2012 entitled Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer.
He's a frequent lecturer and speaker at conferences on the topic of cancer, impaired mitochondrial function, and using ketogenic diets and fasting tactics as therapy to treat and avoid cancer.
This was personally an important episode for me. I hope you feel more in control of your cancer risk after listening to it, as I do having followed Dr. Seyfried's work.
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How Dr. Seyfried pooled research from over 50 years together to develop his conclusions on cancer and the mitochondria (18:00). Therapeutic ketosis and fasting can enhance mitochondria (23:00). Ketone bodies produce cleaner energy, with less oxidative stress (ROS) than glucose molecules, when used for fuel in the mitochondria (27:00). Nuclear genetic mutations prevent cancer cells from adapting to use ketone bodies as their energy source (29:30). Which biomarkers could be indicative of cancer risk? (33:10). Using therapeutic fasting of several days to improve your metabolism (36:00). Using combined blood glucose - ketone meters to take readings and using Dr. Seyfried's calculator to calculate Glucose - Ketone Indices (38:00).
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Dr. Thomas Seyfried
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Dr. Thomas Seyfried at Boston College Cancer as a Metabolic Disease, Journal of Nutrition and Metabolism, 2010 Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer, 2012. Dr. Seyfried's PubMed results
The Tracking
Biomarkers Blood Glucose: A measure of the level of glucose in the blood at one point in time. Dr. Seyfried's therapies target reduction of blood glucose levels to limit cancer cell growth, and according to his theories high blood glucose is a biomarker of increased cancer risk. Glucose - Ketone Index (GKI): The ratio between the concentration of glucose in the blood to ketone bodies in the blood. The calculation is Glucose (mmol)/ Ketone (mmol). Dr. Seyfried created the index as a better way to assess metabolic status. Therapeutic efficacy is considered best with index values approaching 1.0 or below. Patients with chronic disease like cancer have index values of 50 or more. Thomas' paper on the use of GKI for cancer patients has just been accepted for publishing: The Glucose Ketone Index Calculator: A Simple Tool to Monitor Therapeutic Efficacy for Metabolic Management of Brain Cancer Glucose Ketone Index - Thomas Seyfried
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Glucose Ketone Index Tracking of a Water Fast as Therapy for Brain Tumors Trial - Thomas Seyfried
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3 - 5 Day Water Only Fasts: A water-only fast of at least 3 days and preferably 5 days is recommended by Dr. Seyfried as a tool to reduce cancer risk and to lower your glucose - ketone index to 1.0. He recommends doing this twice yearly. For cancer patients he recommends much more intensive use of the water fast.
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There are many approaches to this, however in Dr. Seyfried's research he has found this doesn't have a significant enough impact on raising ketone bodies to be therapeutic. He has only seen this via the water-fast. Hyperbaric Oxygen Therapy (HBOT): Another therapy Dr. Seyfried believes may be beneficial to fight cancer but is relatively non-toxic in comparison to current treatment modalities (chemo and immunotherapies), and would like to trial in conjunction with fasting protocols.
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3-Bromopyruvate (3BP): Dr. Seyfried would like to incorporate this non-toxic molecule in combination with fasting therapies to treat cancer patients.
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Valter Longo PhD.: Dr. Seyfried referred to Valter Longo's work at the University of Southern California on the impacts of fasting on patients undergoing chemotherapy.
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Calorie Restriction Society/ CR Society: Dr. Seyfried pointed out that members of this association that practice ketogenic state inducing low calorie diets have a very low rate of cancer.
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[Damien Blenkinsopp]: Thomas, thank you so much for joining us today.
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[Dr. Thomas Seyfried]: Thank you.
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[Dr. Thomas Seyfried]: Well, it's not that my theory is new.
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[Dr. Thomas Seyfried]: That's correct.
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[Dr. Thomas Seyfried]: No, there was no mitochondria before oxygen came on the planet.
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[Dr. Thomas Seyfried]: Well it's not that they're not there.
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[Dr. Thomas Seyfried]: Yeah, what you said there is referred to as the Oncogenic Paradox, which has been discussed by Albert Szent-Gyorgyi, who received a Novel Prize for his work on Vitamin C and energy metabolism and these things, and John Cohn from England.
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[Dr. Thomas Seyfried]: Lose the genomic integrity.
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[Dr. Thomas Seyfried]: Yeah.
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[Dr. Thomas Seyfried]: Yeah, it's very interesting.
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[Dr. Thomas Seyfried]: I think that's an extremely important point.
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[Dr. Thomas Seyfried]: Well, it's already gaining a lot of traction.
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[Dr. Thomas Seyfried]: Yes, I think you're absolutely right.
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[Dr. Thomas Seyfried]: Absolutely.
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[Dr. Thomas Seyfried]: Yeah, it makes no sense.
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[Dr. Thomas Seyfried]: Well, those diseases, that's true.
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[Dr. Thomas Seyfried]: Yeah, well the body is very flexible.
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[Dr. Thomas Seyfried]: Yeah!
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[Dr. Thomas Seyfried]: It's the same thing.
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[Dr. Thomas Seyfried]: Oh, absolutely. Absolutely.
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[Dr. Thomas Seyfried]: It's a very close analogy.
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[Dr. Thomas Seyfried]: Yeah, well I think one of the risks of cancer is high blood sugar, blood glucose levels.
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[Dr. Thomas Seyfried]: Oh no, no.
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[Dr. Thomas Seyfried]: It's not dangerous. When you take somebody who has Type 2 diabetes, and his blood sugar is like 300 milligrams per deciliter - and you have to divide that by the number 18 to bring it down to millimolar - and his ketones, you can't even measure them. I mean, these guys are inflamed.
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[Dr. Thomas Seyfried]: Yeah.
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[Dr. Thomas Seyfried]: Yeah, I know Jimmy.
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[Dr. Thomas Seyfried]: There's a couple of companies that use the blood test, the most accurate. It's more accurate than the breath, blowing into a ketosis meter.
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[Dr. Thomas Seyfried]: We developed the calculation. It's called the Ketone Index Calculator.
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[Dr. Thomas Seyfried]: Well, we don't have that yet.
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[Dr. Thomas Seyfried]: This is the thing. So people, regardless of whether you're a cancer patient and you want to manage your disease, or you're a person who wants to prevent cancer, or you're an athlete who wants to know what his physiological status is, or you're someone who wants to lose weight.
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[Dr. Thomas Seyfried]: Yes. Exactly.
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[Dr. Thomas Seyfried]: Yes. You're absolutely right about this.
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[Dr. Thomas Seyfried]: Yes, it's an economy of scale, absolutely.
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[Dr. Thomas Seyfried]: Well intermittent fasting is, from what we've seen in our work, you don't get the health benefits, the power of the health benefit, until you've gone three to four days without any food. Just drinking water.
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[Dr. Thomas Seyfried]: Yeah, but then you've got to know, okay what did that do to my index?
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[Dr. Thomas Seyfried]: Yeah, no, that's a really important point. It's certain people. It's also certain sexes.
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[Dr. Thomas Seyfried]: Absolutely.
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[Dr. Thomas Seyfried]: Well, in my book I called it autolytic cannibalism.
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[Dr. Thomas Seyfried]: Yeah, that's kind of hard to do, because we all have lactate in our bloodstream, and the lactate comes from erythrocytes, our blood cells.
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[Dr. Thomas Seyfried]: Yes, because it reduces inflammation.
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[Damien Blenkinsopp]: Thank you so much for this interview[unclear 53:08] Thomas.
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[Dr. Thomas Seyfried]: Yeah, well I think the people themselves are demanding a change.
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[Dr. Thomas Seyfried]: Yeah, I think it will help a lot, like you said, with the lipids.
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[Dr. Thomas Seyfried]: Well, I wrote the book On Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of the Disease. That's published by John Wiley Press.
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[Dr. Thomas Seyfried]: Yeah.
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[Dr. Thomas Seyfried]: Well, basically I try to get on a scale and see how much I weigh.
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[Dr. Thomas Seyfried]: I would stop eating.
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[Dr. Thomas Seyfried]: I'd get my index down below 1, that's for sure.
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[Dr. Thomas Seyfried]: Yes! Exactly.
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[Dr. Thomas Seyfried]: Yeah.
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[Dr. Thomas Seyfried]: Yeah, I a
861: Dr. Thomas Seyfried - ...
llvlcshow.libsyn.com, 27 Aug 2014 [cached]
861: Dr. Thomas Seyfried - KETO CLARITY Expert Interview
Ketogenic diet and cancer researcher Dr. Thomas Seyfried is our interview guest today in a series of exclusive podcasts featuring the various experts from Jimmy Moore's new book Keto Clarity in Episode 861 of "The Livin' La Vida Low-Carb Show."
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Today's Keto Clarity expert interview is with Dr. Thomas Seyfried, a Boston College professor of biology and ketogenic diet/cancer researcher. He got his PhD in genetics and biochemistry from the University of Illinois, Urbana and did his undergraduate work at the University of New England. Dr. Seyfried also has a Master's Degree in genetics and was a postdoctoral fellow in the Department of Neurology at the Yale University School of Medicine followed by serving as the faculty as an assistant professor of neurology. He released a seminal book about the work he is doing using a calorie-restricted low-carb, high-fat, ketogenic diet in cancer research on mice entitled Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer. Dr. Seyfried also does research focusing on gene and environment interactions related to complex diseases such as epilepsy, autism, brain cancer, and neurodegenerative diseases. Listen in as Jimmy and Dr. Seyfried discuss the behind-the-scenes of the research world and the potential for disease control that a ketogenic diet possesses.
Dr. Thomas ...
www.rsg1foundation.com, 8 Aug 2015 [cached]
Dr. Thomas Seyfried
Boston College
ASN NEURO Editorial Board Member
www.asnneuro.org, 10 April 2014 [cached]
Thomas Seyfried ASN NEURO Editorial Board Member
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Thomas N. Seyfried - Senior Editor
Dr. Seyfried's research program focuses on dietary therapies for epilepsy, brain cancer, autism and neurodegenerative lipid storage diseases.
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