A Review of Thomas Seyfried's Cancer As a Metabolic Disease
Once in a long while, a book comes along that revolutionizes our understanding of the cancer problem.
Such a book is Cancer as a Metabolic Disease (Wiley 2012) by Thomas N. Seyfried, PhD.
Formerly a cancer researcher at Yale University, Seyfried is a professor of biology at Boston College and the author of more than 150 PubMed- indexed scientific articles.
Cancer as a Metabolic Disease is the most significant book I have read in my 50 years in this field.
It should be required reading of all cancer specialists, physicians in general, scientific researchers in the field of cancer and for medical students.
I cannot overstate what a valuable contribution Thomas Seyfried
has made in writing this masterpiece.
proposes an alternative view; that is, that the key lethal flaw in cancer does not originate in the nucleus at all but in the mitochondria.
Warburg's point of view, says Seyfried
, was fundamentally right.
But, with the perspective of time, his
theory had some weaknesses as well.
In fact, it was only fairly recently that Seyfried
and others showed that this utilization of oxygen by tumors is without any energy-generating capacity.
It is oxidation "uncoupled" from any normal or productive usage.
Due to the work of Prof. Peter Pedersen of Johns Hopkins University, Seyfried, and others, Warburg's theory is now experiencing an unexpected revival.
In this comprehensive book, Seyfried
shows that oxidative insufficiency and its resulting compensatory fermentation cause genome instability.
"All hallmarks of cancer including the Warburg effect can be linked to impaired respiration and energy metabolism," he
writes (p. 26).
In the tradition of Otto Warburg, Dean Burk, and Peter Pedersen, Thomas Seyfried
has attempted to inform the world about the nature of cancer and of more effective ways that this scourge can be brought under control.